The Dihydrouracil/Uracil Ratios in Plasma and Toxicities of 5-Fluorouracil-Based Adjuvant Chemotherapy in Colorectal Cancer Patients

Background: This study was designed to measure the dihydrouracil (UH 2 )/uracil (U) ratio in plasma as a surrogate marker for dihydropyrimidine dehydrogenase (DPD) activity and to investigate the relationships of the UH 2 /U ratios in plasma with the toxicities of 5-fluorouracil (5-FU)-based adjuvan...

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Veröffentlicht in:	Chemotherapy (Basel) 2007-01, Vol.53 (2), p.127-131
Hauptverfasser:	Zhou, Zhi Wei, Wang, Guo Qiang, Wan, De Sen, Lu, Zhen Hai, Chen, Ying Bo, Li, Su, Chen, Gong, Pan, Zhi Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - pharmacokinetics Antimetabolites, Antineoplastic - therapeutic use Chemotherapy Chemotherapy, Adjuvant Clinical Study Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Female Fluorouracil - adverse effects Fluorouracil - pharmacokinetics Fluorouracil - therapeutic use Humans Leucovorin - therapeutic use Male Middle Aged Pharmacology Toxicity Uracil - analogs & derivatives Uracil - blood Vitamin B Complex - therapeutic use
Online-Zugang:	Volltext
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