Stimulatory Effects of 6-Methylsulfinylhexyl Isothiocyanate on Cultured Human Follicle Dermal Papilla Cells
Wasabi is a member of the Brassicaceae family and produces various isothiocyanates (ITCs). Because 6-methylsulfinylhexyl ITC (6-MSITC) is stable among wasabi ITCs, it has potential as a functional compound. Hair loss can have psychological and social effects on an individual because of its impact on...
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| Veröffentlicht in: | FOOD SCIENCE AND TECHNOLOGY RESEARCH 2018, Vol.24(3), pp.567-572 |
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| container_title | FOOD SCIENCE AND TECHNOLOGY RESEARCH |
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| creator | Yamada-Kato, Tomoe Okunishi, Isao Fukamatsu, Yosuke Tsuboi, Hidenori Yoshida, Yusuke |
| description | Wasabi is a member of the Brassicaceae family and produces various isothiocyanates (ITCs). Because 6-methylsulfinylhexyl ITC (6-MSITC) is stable among wasabi ITCs, it has potential as a functional compound. Hair loss can have psychological and social effects on an individual because of its impact on appearance. In this study, we investigated the stimulatory effects of 6-MSITC by culturing on human follicle dermal papilla cells (DPCs). Results showed that 6-MSITC significantly promoted DPC proliferation and upregulated vascular endothelial growth factor (VEGF) mRNA levels compared to control. Furthermore, 6-MSITC significantly upregulated adenosine A2b receptor (ADORA2b) mRNA levels. Previous studies have reported that VEGF was induced through ADORA1 and ADORA2 pathways. We suggest that 6-MSITC stimulates hair growth on DPCs related to the upregulation of ADORA2b mRNA level. Thus, 6-MSITC may be used as a functional compound. |
| doi_str_mv | 10.3136/fstr.24.567 |
| format | Article |
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Because 6-methylsulfinylhexyl ITC (6-MSITC) is stable among wasabi ITCs, it has potential as a functional compound. Hair loss can have psychological and social effects on an individual because of its impact on appearance. In this study, we investigated the stimulatory effects of 6-MSITC by culturing on human follicle dermal papilla cells (DPCs). Results showed that 6-MSITC significantly promoted DPC proliferation and upregulated vascular endothelial growth factor (VEGF) mRNA levels compared to control. Furthermore, 6-MSITC significantly upregulated adenosine A2b receptor (ADORA2b) mRNA levels. Previous studies have reported that VEGF was induced through ADORA1 and ADORA2 pathways. We suggest that 6-MSITC stimulates hair growth on DPCs related to the upregulation of ADORA2b mRNA level. 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Because 6-methylsulfinylhexyl ITC (6-MSITC) is stable among wasabi ITCs, it has potential as a functional compound. Hair loss can have psychological and social effects on an individual because of its impact on appearance. In this study, we investigated the stimulatory effects of 6-MSITC by culturing on human follicle dermal papilla cells (DPCs). Results showed that 6-MSITC significantly promoted DPC proliferation and upregulated vascular endothelial growth factor (VEGF) mRNA levels compared to control. Furthermore, 6-MSITC significantly upregulated adenosine A2b receptor (ADORA2b) mRNA levels. Previous studies have reported that VEGF was induced through ADORA1 and ADORA2 pathways. We suggest that 6-MSITC stimulates hair growth on DPCs related to the upregulation of ADORA2b mRNA level. Thus, 6-MSITC may be used as a functional compound.</description><subject>6-methylsulfinylhexyl isothiocyanate</subject><subject>Adenosine</subject><subject>Cell proliferation</subject><subject>Growth factors</subject><subject>Hair</subject><subject>hair growth</subject><subject>human follicle dermal papilla cells</subject><subject>Isothiocyanate</subject><subject>Level (quantity)</subject><subject>mRNA</subject><subject>Skin</subject><subject>Vascular endothelial growth factor</subject><subject>wasabi</subject><issn>1344-6606</issn><issn>1881-3984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpFkFtr3DAQhU1poWmap_wBQR-Lt7qMZPmlULa5QUICaZ-Foh11vZWtrSRD_e-rZcP2YS4wZ84Hp2kuGV0JJtQXn0tacVhJ1b1pzpjWrBW9hrd1FwCtUlS9bz7kvKOUyV7zs-b3cxnGOdgS00KuvEdXMomeqPYBy3YJeQ5-mJawxb9LIHc5lu0Q3WInW5DEiaznUOaEG3I7j3Yi1zGEwQUk3zGNNpAnux9CsGSNIeSPzTtvQ8aL13ne_Ly--rG-be8fb-7W3-5bJzWUFjrdd5wj9b7ve8oddNZ5cIp5xA46D4hagxQvwLqNetHeWyepFYpLKsGL8-bT0Xef4p8ZczG7OKepIg3ngjPegxZV9fmocinmnNCbfRpGmxbDqDmkaQ5pGg6mplnVN0f1iJvB2RCnMEz439iP4GPcVAJl2lDKgQpDea36XVvHRc-kFrI6fT067XKxv_BEtakckjtRxSv6dHBbmwxO4h-CcZbr</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Yamada-Kato, Tomoe</creator><creator>Okunishi, Isao</creator><creator>Fukamatsu, Yosuke</creator><creator>Tsuboi, Hidenori</creator><creator>Yoshida, Yusuke</creator><general>Japanese Society for Food Science and Technology</general><general>The Japanese Society for Food Science and Technology</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>2018</creationdate><title>Stimulatory Effects of 6-Methylsulfinylhexyl Isothiocyanate on Cultured Human Follicle Dermal Papilla Cells</title><author>Yamada-Kato, Tomoe ; Okunishi, Isao ; Fukamatsu, Yosuke ; Tsuboi, Hidenori ; Yoshida, Yusuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-4789722e0ff99902c47acf4c61fee747f4ee88453b417d6b8ffac50a3625054f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>6-methylsulfinylhexyl isothiocyanate</topic><topic>Adenosine</topic><topic>Cell proliferation</topic><topic>Growth factors</topic><topic>Hair</topic><topic>hair growth</topic><topic>human follicle dermal papilla cells</topic><topic>Isothiocyanate</topic><topic>Level (quantity)</topic><topic>mRNA</topic><topic>Skin</topic><topic>Vascular endothelial growth factor</topic><topic>wasabi</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada-Kato, Tomoe</creatorcontrib><creatorcontrib>Okunishi, Isao</creatorcontrib><creatorcontrib>Fukamatsu, Yosuke</creatorcontrib><creatorcontrib>Tsuboi, Hidenori</creatorcontrib><creatorcontrib>Yoshida, Yusuke</creatorcontrib><creatorcontrib>ACEL</creatorcontrib><creatorcontrib>Inc</creatorcontrib><creatorcontrib>Research & Development Division</creatorcontrib><creatorcontrib>Kinjirushi Co</creatorcontrib><creatorcontrib>Ltd</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>FOOD SCIENCE AND TECHNOLOGY RESEARCH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada-Kato, Tomoe</au><au>Okunishi, Isao</au><au>Fukamatsu, Yosuke</au><au>Tsuboi, Hidenori</au><au>Yoshida, Yusuke</au><aucorp>ACEL</aucorp><aucorp>Inc</aucorp><aucorp>Research & Development Division</aucorp><aucorp>Kinjirushi Co</aucorp><aucorp>Ltd</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulatory Effects of 6-Methylsulfinylhexyl Isothiocyanate on Cultured Human Follicle Dermal Papilla Cells</atitle><jtitle>FOOD SCIENCE AND TECHNOLOGY RESEARCH</jtitle><addtitle>Food Science and Technology Research</addtitle><date>2018</date><risdate>2018</risdate><volume>24</volume><issue>3</issue><spage>567</spage><epage>572</epage><pages>567-572</pages><issn>1344-6606</issn><eissn>1881-3984</eissn><abstract>Wasabi is a member of the Brassicaceae family and produces various isothiocyanates (ITCs). Because 6-methylsulfinylhexyl ITC (6-MSITC) is stable among wasabi ITCs, it has potential as a functional compound. Hair loss can have psychological and social effects on an individual because of its impact on appearance. In this study, we investigated the stimulatory effects of 6-MSITC by culturing on human follicle dermal papilla cells (DPCs). Results showed that 6-MSITC significantly promoted DPC proliferation and upregulated vascular endothelial growth factor (VEGF) mRNA levels compared to control. Furthermore, 6-MSITC significantly upregulated adenosine A2b receptor (ADORA2b) mRNA levels. Previous studies have reported that VEGF was induced through ADORA1 and ADORA2 pathways. We suggest that 6-MSITC stimulates hair growth on DPCs related to the upregulation of ADORA2b mRNA level. 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| ispartof | Food Science and Technology Research, 2018, Vol.24(3), pp.567-572 |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 6-methylsulfinylhexyl isothiocyanate Adenosine Cell proliferation Growth factors Hair hair growth human follicle dermal papilla cells Isothiocyanate Level (quantity) mRNA Skin Vascular endothelial growth factor wasabi |
| title | Stimulatory Effects of 6-Methylsulfinylhexyl Isothiocyanate on Cultured Human Follicle Dermal Papilla Cells |
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