A second cytotoxic proteolytic peptide derived from amyloid [beta]-protein precursor

The amyloid beta-protein precursor gives rise to the amyloid beta-protein, the principal constituent of senile plaques and a cytotoxic fragment involved in the pathogenesis of Alzheimer disease. Here we show that amyloid beta-protein precursor was proteolytically cleaved by caspases in the C terminu...

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Veröffentlicht in:	Nature medicine 2000-04, Vol.6 (4), p.397
Hauptverfasser:	Lu, Daniel C, Rabizadeh, Shahrooz, Chandra, Sreeganga, Shayya, Rana F, Ellerby, Lisa M, Ye, Xin, Salvesen, Guy S, Koo, Edward H, Bredesen, Dale E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amino acids Apoptosis Cell death Cytotoxicity Monoclonal antibodies Pathogenesis Peptides Proteins Toxicity
Online-Zugang:	Volltext
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