Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-[beta] signaling

The latent transcription factor Stat3 is activated by gp130, the common receptor for the interleukin (IL)-6 cytokine family and other growth factor and cytokine receptors. Ligand-induced dimerization of gp130 leads to activation of the Stat1, Stat3 and Shp2-Ras-Erk signaling pathways. Here we assess...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nature medicine 2005-08, Vol.11 (8), p.845
Hauptverfasser:	Jenkins, Brendan J, Grail, Dianne, Nheu, Thao, Najdovska, Meri, Wang, Bo, Waring, Paul, Inglese, Melissa, McLoughlin, Rachel M, Jones, Simon A, Topley, Nicholas, Baumann, Heinz, Judd, Louise M, Giraud, Andrew S, Boussioutas, Alex, Hong-Jian, Zhu, Ernst, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Lesions Life span Lymphocytes Mutation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!