Loss of HIF-2[alpha] and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Respiratory distress syndrome (RDS) due to insufficient production of surfactant is a common and severe complication of preterm delivery. Here, we report that loss of the hypoxia-inducible transcription factor-2alpha (HIF-2alpha) caused fatal RDS in neonatal mice due to insufficient surfactant produ...

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Veröffentlicht in:	Nature medicine 2002-07, Vol.8 (7), p.702
Hauptverfasser:	Compernolle, Veerle, Brusselmans, Koen, Acker, Till, Hoet, Peter, Tjwa, Marc, Beck, Heike, Plaisance, Stéphane, Dor, Yuval, Keshet, Eli, Lupu, Florea, Nemery, Benoit, Dewerchin, Mieke, Paul Van Veldhoven, Plate, Karl, Moons, Lieve, Collen, Désiré, Carmeliet, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Hypoxia Infants Surfactants
Online-Zugang:	Volltext
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