Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice

Short-chain fatty acids (SCFAs) have been reported to ameliorate obesity. However, the underlying mechanisms require further investigation. The aim of this study was to determine the role of butyrate, an SCFA, in the regulation of obesity, low-grade chronic inflammation, and alterations of microbiot...

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Veröffentlicht in:	The Journal of nutrition 2019-05, Vol.149 (5), p.747-754
Hauptverfasser:	Fang, Wanjun, Xue, Hongliang, Chen, Xu, Chen, Ke, Ling, Wenhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body weight Body weight gain butyrate Butyric Acid - pharmacology Butyric Acid - therapeutic use Colon Colon - drug effects Colon - metabolism Colon - microbiology Composition Diet Diet, High-Fat Dietary Fats - adverse effects Dietary Fats - blood Dietary Supplements Digestive system Drinking water Dysbiosis - etiology Dysbiosis - prevention & control Fatty acids Gastrointestinal Microbiome - drug effects Gastrointestinal tract Gene expression gut microbiota High fat diet Ileum Ileum - drug effects Ileum - metabolism inflammation Inflammation - blood Inflammation - etiology Inflammation - prevention & control Interleukin 6 Interleukin-6 - blood Intestine Intestines - drug effects Intestines - microbiology Lipids Lipids - blood lipopolysaccharide Lipopolysaccharides Lipopolysaccharides - blood Liver - drug effects Liver - metabolism Low fat diet Male Mice, Inbred C57BL Microbiota Nutrient deficiency Obesity Obesity - drug therapy Obesity - metabolism Obesity - microbiology Obesity - pathology Occludin - metabolism Principal components analysis Sodium Sodium butyrate Triglycerides - metabolism Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-α Weight Gain - drug effects Zonula Occludens-1 Protein - metabolism
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