Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice
Short-chain fatty acids (SCFAs) have been reported to ameliorate obesity. However, the underlying mechanisms require further investigation. The aim of this study was to determine the role of butyrate, an SCFA, in the regulation of obesity, low-grade chronic inflammation, and alterations of microbiot...
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| description | Short-chain fatty acids (SCFAs) have been reported to ameliorate obesity. However, the underlying mechanisms require further investigation.
The aim of this study was to determine the role of butyrate, an SCFA, in the regulation of obesity, low-grade chronic inflammation, and alterations of microbiota composition in mice.
Male C57BL/6J mice, 4–5 wk of age, were divided into 3 groups (n = 8 mice/group): low-fat diet (LFD; 10% energy from fat), high-fat diet (HFD; 45% energy from fat), or high-fat diet plus sodium butyrate (HSB). HSB mice received sodium butyrate at a concentration of 0.1 M in drinking water for 12 wk. Measures of inflammation, obesity, and intestinal integrity were assessed. Serum lipopolysaccharide (LPS) concentrations were measured in the 3 groups. Fecal samples were collected for gut microbiota analysis.
In HFD mice, body weight gain and hepatic triglyceride (TG), serum interleukin-6 (IL-6), and serum tumor necrosis factor (TNF)-α levels were 1–4 times higher than those in LFD mice (P |
| doi_str_mv | 10.1093/jn/nxy324 |
| format | Article |
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The aim of this study was to determine the role of butyrate, an SCFA, in the regulation of obesity, low-grade chronic inflammation, and alterations of microbiota composition in mice.
Male C57BL/6J mice, 4–5 wk of age, were divided into 3 groups (n = 8 mice/group): low-fat diet (LFD; 10% energy from fat), high-fat diet (HFD; 45% energy from fat), or high-fat diet plus sodium butyrate (HSB). HSB mice received sodium butyrate at a concentration of 0.1 M in drinking water for 12 wk. Measures of inflammation, obesity, and intestinal integrity were assessed. Serum lipopolysaccharide (LPS) concentrations were measured in the 3 groups. Fecal samples were collected for gut microbiota analysis.
In HFD mice, body weight gain and hepatic triglyceride (TG), serum interleukin-6 (IL-6), and serum tumor necrosis factor (TNF)-α levels were 1–4 times higher than those in LFD mice (P < 0.05); they were 34–42% lower in HSB mice compared with HFD mice (P < 0.05). The HFD group had 28%–48% lower mRNA expression of both Tjp1 and Ocln in the ileum and colon compared with levels in LFD or HSB mice (P < 0.05), whereas there was no difference in expression levels between LFD and HSB mice. Furthermore, in HSB mice, serum LPS concentration was 53% lower compared with that in HFD mice but still 23% higher than that in LFD mice (P < 0.05). Results from principal component analysis showed that HSB and LFD mice had a similar gut microbiota structure, which was significantly different from that in HFD mice (P < 0.05).
Sodium butyrate administration beneficially changed HFD-induced gut microbiota composition and improved intestinal barrier, leading to lower serum LPS concentrations. These changes may correspond with improvements in obesity-related lipid accumulation and low-grade chronic inflammation.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/nxy324</identifier><identifier>PMID: 31004166</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Body weight ; Body weight gain ; butyrate ; Butyric Acid - pharmacology ; Butyric Acid - therapeutic use ; Colon ; Colon - drug effects ; Colon - metabolism ; Colon - microbiology ; Composition ; Diet ; Diet, High-Fat ; Dietary Fats - adverse effects ; Dietary Fats - blood ; Dietary Supplements ; Digestive system ; Drinking water ; Dysbiosis - etiology ; Dysbiosis - prevention & control ; Fatty acids ; Gastrointestinal Microbiome - drug effects ; Gastrointestinal tract ; Gene expression ; gut microbiota ; High fat diet ; Ileum ; Ileum - drug effects ; Ileum - metabolism ; inflammation ; Inflammation - blood ; Inflammation - etiology ; Inflammation - prevention & control ; Interleukin 6 ; Interleukin-6 - blood ; Intestine ; Intestines - drug effects ; Intestines - microbiology ; Lipids ; Lipids - blood ; lipopolysaccharide ; Lipopolysaccharides ; Lipopolysaccharides - blood ; Liver - drug effects ; Liver - metabolism ; Low fat diet ; Male ; Mice, Inbred C57BL ; Microbiota ; Nutrient deficiency ; Obesity ; Obesity - drug therapy ; Obesity - metabolism ; Obesity - microbiology ; Obesity - pathology ; Occludin - metabolism ; Principal components analysis ; Sodium ; Sodium butyrate ; Triglycerides - metabolism ; Tumor Necrosis Factor-alpha - blood ; Tumor necrosis factor-α ; Weight Gain - drug effects ; Zonula Occludens-1 Protein - metabolism</subject><ispartof>The Journal of nutrition, 2019-05, Vol.149 (5), p.747-754</ispartof><rights>2019 American Society for Nutrition.</rights><rights>Copyright © American Society for Nutrition 2019.</rights><rights>Copyright American Institute of Nutrition May 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-e91e1f2e849a006d876ebc30511584aa1333386092357761d56c70fe1d3535c23</citedby><cites>FETCH-LOGICAL-c392t-e91e1f2e849a006d876ebc30511584aa1333386092357761d56c70fe1d3535c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31004166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Wanjun</creatorcontrib><creatorcontrib>Xue, Hongliang</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Chen, Ke</creatorcontrib><creatorcontrib>Ling, Wenhua</creatorcontrib><title>Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Short-chain fatty acids (SCFAs) have been reported to ameliorate obesity. However, the underlying mechanisms require further investigation.
The aim of this study was to determine the role of butyrate, an SCFA, in the regulation of obesity, low-grade chronic inflammation, and alterations of microbiota composition in mice.
Male C57BL/6J mice, 4–5 wk of age, were divided into 3 groups (n = 8 mice/group): low-fat diet (LFD; 10% energy from fat), high-fat diet (HFD; 45% energy from fat), or high-fat diet plus sodium butyrate (HSB). HSB mice received sodium butyrate at a concentration of 0.1 M in drinking water for 12 wk. Measures of inflammation, obesity, and intestinal integrity were assessed. Serum lipopolysaccharide (LPS) concentrations were measured in the 3 groups. Fecal samples were collected for gut microbiota analysis.
In HFD mice, body weight gain and hepatic triglyceride (TG), serum interleukin-6 (IL-6), and serum tumor necrosis factor (TNF)-α levels were 1–4 times higher than those in LFD mice (P < 0.05); they were 34–42% lower in HSB mice compared with HFD mice (P < 0.05). The HFD group had 28%–48% lower mRNA expression of both Tjp1 and Ocln in the ileum and colon compared with levels in LFD or HSB mice (P < 0.05), whereas there was no difference in expression levels between LFD and HSB mice. Furthermore, in HSB mice, serum LPS concentration was 53% lower compared with that in HFD mice but still 23% higher than that in LFD mice (P < 0.05). Results from principal component analysis showed that HSB and LFD mice had a similar gut microbiota structure, which was significantly different from that in HFD mice (P < 0.05).
Sodium butyrate administration beneficially changed HFD-induced gut microbiota composition and improved intestinal barrier, leading to lower serum LPS concentrations. These changes may correspond with improvements in obesity-related lipid accumulation and low-grade chronic inflammation.</description><subject>Animals</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>butyrate</subject><subject>Butyric Acid - pharmacology</subject><subject>Butyric Acid - therapeutic use</subject><subject>Colon</subject><subject>Colon - drug effects</subject><subject>Colon - metabolism</subject><subject>Colon - microbiology</subject><subject>Composition</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Dietary Fats - adverse effects</subject><subject>Dietary Fats - blood</subject><subject>Dietary Supplements</subject><subject>Digestive system</subject><subject>Drinking water</subject><subject>Dysbiosis - etiology</subject><subject>Dysbiosis - prevention & control</subject><subject>Fatty acids</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Gastrointestinal tract</subject><subject>Gene expression</subject><subject>gut microbiota</subject><subject>High fat diet</subject><subject>Ileum</subject><subject>Ileum - drug effects</subject><subject>Ileum - metabolism</subject><subject>inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - etiology</subject><subject>Inflammation - prevention & control</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - blood</subject><subject>Intestine</subject><subject>Intestines - drug effects</subject><subject>Intestines - microbiology</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>lipopolysaccharide</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - blood</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Low fat diet</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiota</subject><subject>Nutrient deficiency</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Obesity - metabolism</subject><subject>Obesity - microbiology</subject><subject>Obesity - pathology</subject><subject>Occludin - metabolism</subject><subject>Principal components analysis</subject><subject>Sodium</subject><subject>Sodium butyrate</subject><subject>Triglycerides - metabolism</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor necrosis factor-α</subject><subject>Weight Gain - drug effects</subject><subject>Zonula Occludens-1 Protein - metabolism</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1PGzEQhq2qqAnQQ_9AZaknDkv8sevdPdJQEiQQB-BsOevZxlHW3voDyF_or8Yk0FPnMqOZZ97RvAh9o-SckpbPNnZmX3aclZ_QlFYlLQQl5DOaEsJYwakQE3QcwoYQQsu2-YImPM_L3J-iv_dpHLcwgI0qGmfxs4lrfO-0SQP-meLOqwj41um0zUXAcQ147obRBbPHXb9vLVLEt6bzbmVcVFhZjS8G2Brn91tL83tdXKmILw3E4trq1IHGdyvIKjts7NsunKKjXm0DfH3PJ-jx6tfDfFnc3C2u5xc3RcdbFgtoKdCeQVO2ihChm1rAquOkorRqSqUoz9EI0jJe1bWguhJdTXqgmle86hg_QT8OuqN3fxKEKDcueZtPSsY4aZhgdZmpswOVnwrBQy9Hbwbld5IS-ea63Fh5cD2z398V02oA_Y_8sDkD_ABA_uvJgJehM2CzCcZDF6V25j-yr8R_kD4</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Fang, Wanjun</creator><creator>Xue, Hongliang</creator><creator>Chen, Xu</creator><creator>Chen, Ke</creator><creator>Ling, Wenhua</creator><general>Elsevier Inc</general><general>American Institute of Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>201905</creationdate><title>Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice</title><author>Fang, Wanjun ; Xue, Hongliang ; Chen, Xu ; Chen, Ke ; Ling, Wenhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-e91e1f2e849a006d876ebc30511584aa1333386092357761d56c70fe1d3535c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>butyrate</topic><topic>Butyric Acid - pharmacology</topic><topic>Butyric Acid - therapeutic use</topic><topic>Colon</topic><topic>Colon - drug effects</topic><topic>Colon - metabolism</topic><topic>Colon - microbiology</topic><topic>Composition</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Dietary Fats - adverse effects</topic><topic>Dietary Fats - blood</topic><topic>Dietary Supplements</topic><topic>Digestive system</topic><topic>Drinking water</topic><topic>Dysbiosis - etiology</topic><topic>Dysbiosis - prevention & control</topic><topic>Fatty acids</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Gastrointestinal tract</topic><topic>Gene expression</topic><topic>gut microbiota</topic><topic>High fat diet</topic><topic>Ileum</topic><topic>Ileum - drug effects</topic><topic>Ileum - metabolism</topic><topic>inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - etiology</topic><topic>Inflammation - prevention & control</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - blood</topic><topic>Intestine</topic><topic>Intestines - drug effects</topic><topic>Intestines - microbiology</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>lipopolysaccharide</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - blood</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Low fat diet</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiota</topic><topic>Nutrient deficiency</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Obesity - metabolism</topic><topic>Obesity - microbiology</topic><topic>Obesity - pathology</topic><topic>Occludin - metabolism</topic><topic>Principal components analysis</topic><topic>Sodium</topic><topic>Sodium butyrate</topic><topic>Triglycerides - metabolism</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor necrosis factor-α</topic><topic>Weight Gain - drug effects</topic><topic>Zonula Occludens-1 Protein - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Wanjun</creatorcontrib><creatorcontrib>Xue, Hongliang</creatorcontrib><creatorcontrib>Chen, Xu</creatorcontrib><creatorcontrib>Chen, Ke</creatorcontrib><creatorcontrib>Ling, Wenhua</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Wanjun</au><au>Xue, Hongliang</au><au>Chen, Xu</au><au>Chen, Ke</au><au>Ling, Wenhua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2019-05</date><risdate>2019</risdate><volume>149</volume><issue>5</issue><spage>747</spage><epage>754</epage><pages>747-754</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Short-chain fatty acids (SCFAs) have been reported to ameliorate obesity. However, the underlying mechanisms require further investigation.
The aim of this study was to determine the role of butyrate, an SCFA, in the regulation of obesity, low-grade chronic inflammation, and alterations of microbiota composition in mice.
Male C57BL/6J mice, 4–5 wk of age, were divided into 3 groups (n = 8 mice/group): low-fat diet (LFD; 10% energy from fat), high-fat diet (HFD; 45% energy from fat), or high-fat diet plus sodium butyrate (HSB). HSB mice received sodium butyrate at a concentration of 0.1 M in drinking water for 12 wk. Measures of inflammation, obesity, and intestinal integrity were assessed. Serum lipopolysaccharide (LPS) concentrations were measured in the 3 groups. Fecal samples were collected for gut microbiota analysis.
In HFD mice, body weight gain and hepatic triglyceride (TG), serum interleukin-6 (IL-6), and serum tumor necrosis factor (TNF)-α levels were 1–4 times higher than those in LFD mice (P < 0.05); they were 34–42% lower in HSB mice compared with HFD mice (P < 0.05). The HFD group had 28%–48% lower mRNA expression of both Tjp1 and Ocln in the ileum and colon compared with levels in LFD or HSB mice (P < 0.05), whereas there was no difference in expression levels between LFD and HSB mice. Furthermore, in HSB mice, serum LPS concentration was 53% lower compared with that in HFD mice but still 23% higher than that in LFD mice (P < 0.05). Results from principal component analysis showed that HSB and LFD mice had a similar gut microbiota structure, which was significantly different from that in HFD mice (P < 0.05).
Sodium butyrate administration beneficially changed HFD-induced gut microbiota composition and improved intestinal barrier, leading to lower serum LPS concentrations. These changes may correspond with improvements in obesity-related lipid accumulation and low-grade chronic inflammation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31004166</pmid><doi>10.1093/jn/nxy324</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Body weight Body weight gain butyrate Butyric Acid - pharmacology Butyric Acid - therapeutic use Colon Colon - drug effects Colon - metabolism Colon - microbiology Composition Diet Diet, High-Fat Dietary Fats - adverse effects Dietary Fats - blood Dietary Supplements Digestive system Drinking water Dysbiosis - etiology Dysbiosis - prevention & control Fatty acids Gastrointestinal Microbiome - drug effects Gastrointestinal tract Gene expression gut microbiota High fat diet Ileum Ileum - drug effects Ileum - metabolism inflammation Inflammation - blood Inflammation - etiology Inflammation - prevention & control Interleukin 6 Interleukin-6 - blood Intestine Intestines - drug effects Intestines - microbiology Lipids Lipids - blood lipopolysaccharide Lipopolysaccharides Lipopolysaccharides - blood Liver - drug effects Liver - metabolism Low fat diet Male Mice, Inbred C57BL Microbiota Nutrient deficiency Obesity Obesity - drug therapy Obesity - metabolism Obesity - microbiology Obesity - pathology Occludin - metabolism Principal components analysis Sodium Sodium butyrate Triglycerides - metabolism Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-α Weight Gain - drug effects Zonula Occludens-1 Protein - metabolism |
| title | Supplementation with Sodium Butyrate Modulates the Composition of the Gut Microbiota and Ameliorates High-Fat Diet-Induced Obesity in Mice |
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