Determination of perillaldehyde in perilla herbs using relative molar sensitivity to single-reference diphenyl sulfone
Perillaldehyde (PRL) is one of the essential oil components derived from perilla plants ( Perilla frutescens Britton) and is a characteristic compound of the traditional medicine “perilla herb (蘇葉)” listed in the The Japanese Pharmacopoeia, 17th edition (JP17). HPLC using an analytical standard of P...
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| Veröffentlicht in: | Journal of natural medicines 2019-06, Vol.73 (3), p.566-576 |
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| creator | Masumoto, Naoko Nishizaki, Yuzo Maruyama, Takeshi Igarashi, Yasushi Nakajima, Kaori Yamazaki, Taichi Kuroe, Miho Numata, Masahiko Ihara, Toshihide Sugimoto, Naoki Sato, Kyoko |
| description | Perillaldehyde (PRL) is one of the essential oil components derived from perilla plants (
Perilla frutescens
Britton) and is a characteristic compound of the traditional medicine “perilla herb (蘇葉)” listed in the
The Japanese Pharmacopoeia, 17th edition
(JP17). HPLC using an analytical standard of PRL has been used to quantitatively determine the PRL content in perilla herb. However, PRL reagents have been reported to decompose easily. In this study, we utilized an alternative quantitative method using on a single reference with relative molar sensitivity (
RMS
) based on the results of experiments performed in two laboratories. It was possible to calculate the exact
RMS
using an offline combination of
1
H-quantitative NMR spectroscopy (
1
H-qNMR) and an HPLC/photodiode array (PDA) detector (or an HPLC/variable-wavelength detector [VWD]). Using the
RMS
of PRL to the single-reference compound diphenyl sulfone (DFS), which is an inexpensive and stable compound, the PRL content in the perilla herb could be determined using HPLC/PDA or HPLC/VWD without the need for the analytical standard of PRL. There was no significant difference between the PRL contents of perilla herb determined using the method employing the single-reference DFS with
RMS
and using the JP17 assay, the calibration curve of which was generated using the analytical standard of PRL with adjusted purity measured by
1
H-qNMR. These results demonstrate that our proposed method using a single reference with
RMS
is suitable for quantitative assays of perilla herb and can be an alternative method for the current assay method defined in the JP17. |
| doi_str_mv | 10.1007/s11418-019-01306-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_2230823928</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2230823928</sourcerecordid><originalsourceid>FETCH-LOGICAL-p180t-8dd8afb1d568cf39e5a2ddfa622b90e6e5424b47279b3c62378812bc6d2b3d783</originalsourceid><addsrcrecordid>eNpFkU1PwzAMhiMEYmPwBzigSJwLSdyl6RGNT2kSFzhHbeNumbK0JO2k_ns6tomD5a_HtuSXkFvOHjhj2WPkPOUqYTwfDZhMsjMy5UryhIkczscYUpZAmsKEXMW4YSwVAPySTIAzLiXIKdk9Y4dha33R2cbTpqYtButc4QyuB4PU-lOFrjGUkfbR-hUN6MaJHdJt44pAI_pox9x2A-0aukccJgFrDOgrpMa2a_SDo7F3dePxmlzUhYt4c_Qz8v368rV4T5afbx-Lp2XScsW6RBmjirrkZi5VVUOO80IYUxdSiDJnKHGeirRMM5HlJVRSQKYUF2UljSjBZApm5P6wtw3NT4-x05umD348qYUApgTkYk_dHam-3KLRbbDbIgz69KYRgAMQx5ZfYfhfw5nei6EPYuhRDP0nhs7gF_TEfKk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2230823928</pqid></control><display><type>article</type><title>Determination of perillaldehyde in perilla herbs using relative molar sensitivity to single-reference diphenyl sulfone</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Masumoto, Naoko ; Nishizaki, Yuzo ; Maruyama, Takeshi ; Igarashi, Yasushi ; Nakajima, Kaori ; Yamazaki, Taichi ; Kuroe, Miho ; Numata, Masahiko ; Ihara, Toshihide ; Sugimoto, Naoki ; Sato, Kyoko</creator><creatorcontrib>Masumoto, Naoko ; Nishizaki, Yuzo ; Maruyama, Takeshi ; Igarashi, Yasushi ; Nakajima, Kaori ; Yamazaki, Taichi ; Kuroe, Miho ; Numata, Masahiko ; Ihara, Toshihide ; Sugimoto, Naoki ; Sato, Kyoko</creatorcontrib><description>Perillaldehyde (PRL) is one of the essential oil components derived from perilla plants (
Perilla frutescens
Britton) and is a characteristic compound of the traditional medicine “perilla herb (蘇葉)” listed in the
The Japanese Pharmacopoeia, 17th edition
(JP17). HPLC using an analytical standard of PRL has been used to quantitatively determine the PRL content in perilla herb. However, PRL reagents have been reported to decompose easily. In this study, we utilized an alternative quantitative method using on a single reference with relative molar sensitivity (
RMS
) based on the results of experiments performed in two laboratories. It was possible to calculate the exact
RMS
using an offline combination of
1
H-quantitative NMR spectroscopy (
1
H-qNMR) and an HPLC/photodiode array (PDA) detector (or an HPLC/variable-wavelength detector [VWD]). Using the
RMS
of PRL to the single-reference compound diphenyl sulfone (DFS), which is an inexpensive and stable compound, the PRL content in the perilla herb could be determined using HPLC/PDA or HPLC/VWD without the need for the analytical standard of PRL. There was no significant difference between the PRL contents of perilla herb determined using the method employing the single-reference DFS with
RMS
and using the JP17 assay, the calibration curve of which was generated using the analytical standard of PRL with adjusted purity measured by
1
H-qNMR. These results demonstrate that our proposed method using a single reference with
RMS
is suitable for quantitative assays of perilla herb and can be an alternative method for the current assay method defined in the JP17.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-019-01306-7</identifier><identifier>PMID: 31016636</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Chromatography, High Pressure Liquid - methods ; Complementary & Alternative Medicine ; Herbal medicine ; Magnetic Resonance Spectroscopy ; Medicinal Chemistry ; Monoterpenes - analysis ; Oils, Volatile - analysis ; Organic chemicals ; Original Paper ; Perilla frutescens - chemistry ; Pharmacology/Toxicology ; Pharmacy ; Phytochemicals ; Plant Sciences ; Sulfones - chemistry ; Vegetable oils</subject><ispartof>Journal of natural medicines, 2019-06, Vol.73 (3), p.566-576</ispartof><rights>The Japanese Society of Pharmacognosy 2019</rights><rights>The Japanese Society of Pharmacognosy 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p180t-8dd8afb1d568cf39e5a2ddfa622b90e6e5424b47279b3c62378812bc6d2b3d783</cites><orcidid>0000-0002-8987-7620</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-019-01306-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-019-01306-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31016636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masumoto, Naoko</creatorcontrib><creatorcontrib>Nishizaki, Yuzo</creatorcontrib><creatorcontrib>Maruyama, Takeshi</creatorcontrib><creatorcontrib>Igarashi, Yasushi</creatorcontrib><creatorcontrib>Nakajima, Kaori</creatorcontrib><creatorcontrib>Yamazaki, Taichi</creatorcontrib><creatorcontrib>Kuroe, Miho</creatorcontrib><creatorcontrib>Numata, Masahiko</creatorcontrib><creatorcontrib>Ihara, Toshihide</creatorcontrib><creatorcontrib>Sugimoto, Naoki</creatorcontrib><creatorcontrib>Sato, Kyoko</creatorcontrib><title>Determination of perillaldehyde in perilla herbs using relative molar sensitivity to single-reference diphenyl sulfone</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Perillaldehyde (PRL) is one of the essential oil components derived from perilla plants (
Perilla frutescens
Britton) and is a characteristic compound of the traditional medicine “perilla herb (蘇葉)” listed in the
The Japanese Pharmacopoeia, 17th edition
(JP17). HPLC using an analytical standard of PRL has been used to quantitatively determine the PRL content in perilla herb. However, PRL reagents have been reported to decompose easily. In this study, we utilized an alternative quantitative method using on a single reference with relative molar sensitivity (
RMS
) based on the results of experiments performed in two laboratories. It was possible to calculate the exact
RMS
using an offline combination of
1
H-quantitative NMR spectroscopy (
1
H-qNMR) and an HPLC/photodiode array (PDA) detector (or an HPLC/variable-wavelength detector [VWD]). Using the
RMS
of PRL to the single-reference compound diphenyl sulfone (DFS), which is an inexpensive and stable compound, the PRL content in the perilla herb could be determined using HPLC/PDA or HPLC/VWD without the need for the analytical standard of PRL. There was no significant difference between the PRL contents of perilla herb determined using the method employing the single-reference DFS with
RMS
and using the JP17 assay, the calibration curve of which was generated using the analytical standard of PRL with adjusted purity measured by
1
H-qNMR. These results demonstrate that our proposed method using a single reference with
RMS
is suitable for quantitative assays of perilla herb and can be an alternative method for the current assay method defined in the JP17.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Complementary & Alternative Medicine</subject><subject>Herbal medicine</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medicinal Chemistry</subject><subject>Monoterpenes - analysis</subject><subject>Oils, Volatile - analysis</subject><subject>Organic chemicals</subject><subject>Original Paper</subject><subject>Perilla frutescens - chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phytochemicals</subject><subject>Plant Sciences</subject><subject>Sulfones - chemistry</subject><subject>Vegetable oils</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1PwzAMhiMEYmPwBzigSJwLSdyl6RGNT2kSFzhHbeNumbK0JO2k_ns6tomD5a_HtuSXkFvOHjhj2WPkPOUqYTwfDZhMsjMy5UryhIkczscYUpZAmsKEXMW4YSwVAPySTIAzLiXIKdk9Y4dha33R2cbTpqYtButc4QyuB4PU-lOFrjGUkfbR-hUN6MaJHdJt44pAI_pox9x2A-0aukccJgFrDOgrpMa2a_SDo7F3dePxmlzUhYt4c_Qz8v368rV4T5afbx-Lp2XScsW6RBmjirrkZi5VVUOO80IYUxdSiDJnKHGeirRMM5HlJVRSQKYUF2UljSjBZApm5P6wtw3NT4-x05umD348qYUApgTkYk_dHam-3KLRbbDbIgz69KYRgAMQx5ZfYfhfw5nei6EPYuhRDP0nhs7gF_TEfKk</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Masumoto, Naoko</creator><creator>Nishizaki, Yuzo</creator><creator>Maruyama, Takeshi</creator><creator>Igarashi, Yasushi</creator><creator>Nakajima, Kaori</creator><creator>Yamazaki, Taichi</creator><creator>Kuroe, Miho</creator><creator>Numata, Masahiko</creator><creator>Ihara, Toshihide</creator><creator>Sugimoto, Naoki</creator><creator>Sato, Kyoko</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-8987-7620</orcidid></search><sort><creationdate>20190601</creationdate><title>Determination of perillaldehyde in perilla herbs using relative molar sensitivity to single-reference diphenyl sulfone</title><author>Masumoto, Naoko ; Nishizaki, Yuzo ; Maruyama, Takeshi ; Igarashi, Yasushi ; Nakajima, Kaori ; Yamazaki, Taichi ; Kuroe, Miho ; Numata, Masahiko ; Ihara, Toshihide ; Sugimoto, Naoki ; Sato, Kyoko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p180t-8dd8afb1d568cf39e5a2ddfa622b90e6e5424b47279b3c62378812bc6d2b3d783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Complementary & Alternative Medicine</topic><topic>Herbal medicine</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medicinal Chemistry</topic><topic>Monoterpenes - analysis</topic><topic>Oils, Volatile - analysis</topic><topic>Organic chemicals</topic><topic>Original Paper</topic><topic>Perilla frutescens - chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phytochemicals</topic><topic>Plant Sciences</topic><topic>Sulfones - chemistry</topic><topic>Vegetable oils</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masumoto, Naoko</creatorcontrib><creatorcontrib>Nishizaki, Yuzo</creatorcontrib><creatorcontrib>Maruyama, Takeshi</creatorcontrib><creatorcontrib>Igarashi, Yasushi</creatorcontrib><creatorcontrib>Nakajima, Kaori</creatorcontrib><creatorcontrib>Yamazaki, Taichi</creatorcontrib><creatorcontrib>Kuroe, Miho</creatorcontrib><creatorcontrib>Numata, Masahiko</creatorcontrib><creatorcontrib>Ihara, Toshihide</creatorcontrib><creatorcontrib>Sugimoto, Naoki</creatorcontrib><creatorcontrib>Sato, Kyoko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masumoto, Naoko</au><au>Nishizaki, Yuzo</au><au>Maruyama, Takeshi</au><au>Igarashi, Yasushi</au><au>Nakajima, Kaori</au><au>Yamazaki, Taichi</au><au>Kuroe, Miho</au><au>Numata, Masahiko</au><au>Ihara, Toshihide</au><au>Sugimoto, Naoki</au><au>Sato, Kyoko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of perillaldehyde in perilla herbs using relative molar sensitivity to single-reference diphenyl sulfone</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>73</volume><issue>3</issue><spage>566</spage><epage>576</epage><pages>566-576</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Perillaldehyde (PRL) is one of the essential oil components derived from perilla plants (
Perilla frutescens
Britton) and is a characteristic compound of the traditional medicine “perilla herb (蘇葉)” listed in the
The Japanese Pharmacopoeia, 17th edition
(JP17). HPLC using an analytical standard of PRL has been used to quantitatively determine the PRL content in perilla herb. However, PRL reagents have been reported to decompose easily. In this study, we utilized an alternative quantitative method using on a single reference with relative molar sensitivity (
RMS
) based on the results of experiments performed in two laboratories. It was possible to calculate the exact
RMS
using an offline combination of
1
H-quantitative NMR spectroscopy (
1
H-qNMR) and an HPLC/photodiode array (PDA) detector (or an HPLC/variable-wavelength detector [VWD]). Using the
RMS
of PRL to the single-reference compound diphenyl sulfone (DFS), which is an inexpensive and stable compound, the PRL content in the perilla herb could be determined using HPLC/PDA or HPLC/VWD without the need for the analytical standard of PRL. There was no significant difference between the PRL contents of perilla herb determined using the method employing the single-reference DFS with
RMS
and using the JP17 assay, the calibration curve of which was generated using the analytical standard of PRL with adjusted purity measured by
1
H-qNMR. These results demonstrate that our proposed method using a single reference with
RMS
is suitable for quantitative assays of perilla herb and can be an alternative method for the current assay method defined in the JP17.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>31016636</pmid><doi>10.1007/s11418-019-01306-7</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-8987-7620</orcidid></addata></record> |
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| ispartof | Journal of natural medicines, 2019-06, Vol.73 (3), p.566-576 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Chromatography, High Pressure Liquid - methods Complementary & Alternative Medicine Herbal medicine Magnetic Resonance Spectroscopy Medicinal Chemistry Monoterpenes - analysis Oils, Volatile - analysis Organic chemicals Original Paper Perilla frutescens - chemistry Pharmacology/Toxicology Pharmacy Phytochemicals Plant Sciences Sulfones - chemistry Vegetable oils |
| title | Determination of perillaldehyde in perilla herbs using relative molar sensitivity to single-reference diphenyl sulfone |
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