Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244

Atrial fibrillation has caused severe burden for people worldwide. Differentiation of fibroblasts into myofibroblasts, and consequent progress in atrial structural remodeling have been considered the basis for persistent atrial fibrillation, yet little is known about the molecular mechanisms underly...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International Heart Journal 2019/03/30, Vol.60(2), pp.374-383
Hauptverfasser:	Sai, Chen, Yunhan, Jiang, Zhao, Jian, Yu, Zhu, Yu, Zhun, Zhezhe, Cao, Fuqin, Tang, Yingbin, Xiao, Ruiyan, Ma
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrial fibrillation Atrial Fibrillation - metabolism Atrial Fibrillation - pathology Atrial Remodeling Becaplermin Cardiac arrhythmia CDC2 Protein Kinase - metabolism Cell Adhesion Cell Aggregation - physiology Cell Differentiation - physiology Cell Movement - physiology Cells, Cultured Cyclin-dependent kinase Cyclin-dependent kinases Fibrillation Fibroblasts Fibroblasts - physiology Fibrosis Focal adhesion Focal Adhesions - physiology Humans Molecular modelling Paxillin Paxillin - metabolism Phosphorylation Platelet derived growth factor BB Platelet-derived growth factor Serine - metabolism Signal Transduction Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!