Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients
Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients Jimmy P.S. Chern , MD 1 , Kai-Hsin Lin , MD 2 , Meng-Yao Lu , MD 2 , Dong-Tsam Lin , MD 2 , Kuo-Sin Lin , MD, PHD 2 , Jong-Dar Chen , MD 1 and Cheng-Chung Fu , MD 1 1 Department of Family Medicine, Tao-Yuan Hospital, Departme...
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| Veröffentlicht in: | Diabetes care 2001-05, Vol.24 (5), p.850-854 |
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| creator | CHERN, Jimmy P. S LIN, Kai-Hsin LU, Meng-Yao LIN, Dong-Tsam LIN, Kuo-Sin CHEN, Jong-Dar FU, Cheng-Chung |
| description | Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients
Jimmy P.S. Chern , MD 1 ,
Kai-Hsin Lin , MD 2 ,
Meng-Yao Lu , MD 2 ,
Dong-Tsam Lin , MD 2 ,
Kuo-Sin Lin , MD, PHD 2 ,
Jong-Dar Chen , MD 1 and
Cheng-Chung Fu , MD 1
1 Department of Family Medicine, Tao-Yuan Hospital, Department of Health, Tao-Yuan
2 Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
Abstract
OBJECTIVE —To study the prevalence of and risk factors for abnormal glucose tolerance in transfusion-dependent β-thalassemic patients.
RESEARCH DESIGN AND METHODS —A total of 89 transfusion-dependent β-thalassemic patients were interviewed. Diabetes was previously diagnosed in 14 of them.
In the remaining 75 patients, 68 participated in an oral glucose tolerance test. Potential risk factors were identified using
the independent t test, χ 2 test, and Fisher’s exact test. Logistic regression analysis was used to select the independent risk factors that best predicted
abnormal glucose tolerance. A two-tailed P value of |
| doi_str_mv | 10.2337/diacare.24.5.850 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_223044085</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A75212119</galeid><sourcerecordid>A75212119</sourcerecordid><originalsourceid>FETCH-LOGICAL-c530t-235590ca955317c125c65e1d1f4ddf3e9c5cb4cd1aa18f66aedbb382776e895e3</originalsourceid><addsrcrecordid>eNptkc-KFDEQxoMo7uzo3ZM0CoJgj_nbnT4O67qKC3oYzyGdVM9kSSdj0o34Wj6Iz2SGaRR0qUOK4lf5iu9D6BnBG8pY-9Y6bXSCDeUbsZECP0Ar0jFRC8HlQ7TChHe16Dp6gS5zvsMYcy7lY3RBCONty-kKfdr2IaZR--rGzyZmqHbRQ9LBQOVCtStdHubsYqjfwRGChTBVv37Wu4P2OmcYnam-6MmVcX6CHg3aZ3i6vGv09f317upDffv55uPV9rY2guGppkyIDhvdCcFIawgVphFALBm4tQODzgjTc2OJ1kQOTaPB9j2TtG0bkJ0Atkavzv8eU_w2Q57U6LIB73WAOGfVYslb3rACvvgHvItzCuU2RSkrZmApCvTmDO21B-XCEKekzR5CccHHAIMr420rKKGkmLtG9T14KXvy4j4en3mTYs4JBnVMbtTphyJYnUJUS4iKciVUCbGsPF_OnvsR7N-FJbUCvFwAnY32wykul_9wxVghT8qvz9TB7Q_fXVEoSj1MkP-X_A0_krRF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223044085</pqid></control><display><type>article</type><title>Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>CHERN, Jimmy P. S ; LIN, Kai-Hsin ; LU, Meng-Yao ; LIN, Dong-Tsam ; LIN, Kuo-Sin ; CHEN, Jong-Dar ; FU, Cheng-Chung</creator><creatorcontrib>CHERN, Jimmy P. S ; LIN, Kai-Hsin ; LU, Meng-Yao ; LIN, Dong-Tsam ; LIN, Kuo-Sin ; CHEN, Jong-Dar ; FU, Cheng-Chung</creatorcontrib><description>Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients
Jimmy P.S. Chern , MD 1 ,
Kai-Hsin Lin , MD 2 ,
Meng-Yao Lu , MD 2 ,
Dong-Tsam Lin , MD 2 ,
Kuo-Sin Lin , MD, PHD 2 ,
Jong-Dar Chen , MD 1 and
Cheng-Chung Fu , MD 1
1 Department of Family Medicine, Tao-Yuan Hospital, Department of Health, Tao-Yuan
2 Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
Abstract
OBJECTIVE —To study the prevalence of and risk factors for abnormal glucose tolerance in transfusion-dependent β-thalassemic patients.
RESEARCH DESIGN AND METHODS —A total of 89 transfusion-dependent β-thalassemic patients were interviewed. Diabetes was previously diagnosed in 14 of them.
In the remaining 75 patients, 68 participated in an oral glucose tolerance test. Potential risk factors were identified using
the independent t test, χ 2 test, and Fisher’s exact test. Logistic regression analysis was used to select the independent risk factors that best predicted
abnormal glucose tolerance. A two-tailed P value of <0.05 was considered to be statistically significant.
RESULTS —The prevalence of impaired glucose tolerance was 8.5% (7 of 82) and that of diabetes was 19.5% (16 of 82). Presentation with
diabetic ketoacidosis was 31.1% (5 of 16). The risk factors for abnormal glucose tolerance found in transfusion-dependent
β-thalassemic patients were serum ferritin concentration and hepatitis C infection.
CONCLUSIONS —The interaction of iron overload and hepatitis C infection worsened the prognosis of thalassemic patients. Aggressive iron-chelation
therapy as well as prevention and treatment of hepatitis C infection should be mandatory in managing glucose homeostasis in
transfusion-dependent β-thalassemic patients in Taiwan.
ADA, American Diabetes Association
IGT, impaired glucose tolerance
OGTT, oral glucose tolerance test
OR, odds ratio
Footnotes
Address correspondence and reprint requests to Kai-Hsin Lin, MD, National Taiwan University Hospital, No. 7, Chungshan S.
Rd., Taipei, Taiwan, 10016, R.O.C. E-mail: link{at}ha.mc.ntu.edu.tw .
Received for publication 3 July 2000 and accepted in revised form 18 January 2001.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/diacare.24.5.850</identifier><identifier>PMID: 11347742</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Abnormalities ; Adolescent ; Adult ; Anemias. Hemoglobinopathies ; beta-Thalassemia - blood ; beta-Thalassemia - complications ; beta-Thalassemia - therapy ; Biological and medical sciences ; Blood Transfusion ; Child ; Complications and side effects ; Diabetes ; Diabetes Mellitus - epidemiology ; Diseases of red blood cells ; Female ; Ferritins - blood ; Glucose ; Glucose Intolerance - epidemiology ; Glucose metabolism ; Hematologic and hematopoietic diseases ; Hepatitis ; Hepatitis B - epidemiology ; Hepatitis C - epidemiology ; Humans ; Iron ; Iron Chelating Agents - therapeutic use ; Male ; Medical sciences ; Patient Compliance ; Prevalence ; Risk Factors ; Taiwan ; Thalassemia ; Tropical medicine</subject><ispartof>Diabetes care, 2001-05, Vol.24 (5), p.850-854</ispartof><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2001 American Diabetes Association</rights><rights>Copyright American Diabetes Association May 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-235590ca955317c125c65e1d1f4ddf3e9c5cb4cd1aa18f66aedbb382776e895e3</citedby><cites>FETCH-LOGICAL-c530t-235590ca955317c125c65e1d1f4ddf3e9c5cb4cd1aa18f66aedbb382776e895e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=955589$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11347742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHERN, Jimmy P. S</creatorcontrib><creatorcontrib>LIN, Kai-Hsin</creatorcontrib><creatorcontrib>LU, Meng-Yao</creatorcontrib><creatorcontrib>LIN, Dong-Tsam</creatorcontrib><creatorcontrib>LIN, Kuo-Sin</creatorcontrib><creatorcontrib>CHEN, Jong-Dar</creatorcontrib><creatorcontrib>FU, Cheng-Chung</creatorcontrib><title>Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients
Jimmy P.S. Chern , MD 1 ,
Kai-Hsin Lin , MD 2 ,
Meng-Yao Lu , MD 2 ,
Dong-Tsam Lin , MD 2 ,
Kuo-Sin Lin , MD, PHD 2 ,
Jong-Dar Chen , MD 1 and
Cheng-Chung Fu , MD 1
1 Department of Family Medicine, Tao-Yuan Hospital, Department of Health, Tao-Yuan
2 Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
Abstract
OBJECTIVE —To study the prevalence of and risk factors for abnormal glucose tolerance in transfusion-dependent β-thalassemic patients.
RESEARCH DESIGN AND METHODS —A total of 89 transfusion-dependent β-thalassemic patients were interviewed. Diabetes was previously diagnosed in 14 of them.
In the remaining 75 patients, 68 participated in an oral glucose tolerance test. Potential risk factors were identified using
the independent t test, χ 2 test, and Fisher’s exact test. Logistic regression analysis was used to select the independent risk factors that best predicted
abnormal glucose tolerance. A two-tailed P value of <0.05 was considered to be statistically significant.
RESULTS —The prevalence of impaired glucose tolerance was 8.5% (7 of 82) and that of diabetes was 19.5% (16 of 82). Presentation with
diabetic ketoacidosis was 31.1% (5 of 16). The risk factors for abnormal glucose tolerance found in transfusion-dependent
β-thalassemic patients were serum ferritin concentration and hepatitis C infection.
CONCLUSIONS —The interaction of iron overload and hepatitis C infection worsened the prognosis of thalassemic patients. Aggressive iron-chelation
therapy as well as prevention and treatment of hepatitis C infection should be mandatory in managing glucose homeostasis in
transfusion-dependent β-thalassemic patients in Taiwan.
ADA, American Diabetes Association
IGT, impaired glucose tolerance
OGTT, oral glucose tolerance test
OR, odds ratio
Footnotes
Address correspondence and reprint requests to Kai-Hsin Lin, MD, National Taiwan University Hospital, No. 7, Chungshan S.
Rd., Taipei, Taiwan, 10016, R.O.C. E-mail: link{at}ha.mc.ntu.edu.tw .
Received for publication 3 July 2000 and accepted in revised form 18 January 2001.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.</description><subject>Abnormalities</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anemias. Hemoglobinopathies</subject><subject>beta-Thalassemia - blood</subject><subject>beta-Thalassemia - complications</subject><subject>beta-Thalassemia - therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Transfusion</subject><subject>Child</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diseases of red blood cells</subject><subject>Female</subject><subject>Ferritins - blood</subject><subject>Glucose</subject><subject>Glucose Intolerance - epidemiology</subject><subject>Glucose metabolism</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hepatitis</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis C - epidemiology</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron Chelating Agents - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Patient Compliance</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Taiwan</subject><subject>Thalassemia</subject><subject>Tropical medicine</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc-KFDEQxoMo7uzo3ZM0CoJgj_nbnT4O67qKC3oYzyGdVM9kSSdj0o34Wj6Iz2SGaRR0qUOK4lf5iu9D6BnBG8pY-9Y6bXSCDeUbsZECP0Ar0jFRC8HlQ7TChHe16Dp6gS5zvsMYcy7lY3RBCONty-kKfdr2IaZR--rGzyZmqHbRQ9LBQOVCtStdHubsYqjfwRGChTBVv37Wu4P2OmcYnam-6MmVcX6CHg3aZ3i6vGv09f317upDffv55uPV9rY2guGppkyIDhvdCcFIawgVphFALBm4tQODzgjTc2OJ1kQOTaPB9j2TtG0bkJ0Atkavzv8eU_w2Q57U6LIB73WAOGfVYslb3rACvvgHvItzCuU2RSkrZmApCvTmDO21B-XCEKekzR5CccHHAIMr420rKKGkmLtG9T14KXvy4j4en3mTYs4JBnVMbtTphyJYnUJUS4iKciVUCbGsPF_OnvsR7N-FJbUCvFwAnY32wykul_9wxVghT8qvz9TB7Q_fXVEoSj1MkP-X_A0_krRF</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>CHERN, Jimmy P. S</creator><creator>LIN, Kai-Hsin</creator><creator>LU, Meng-Yao</creator><creator>LIN, Dong-Tsam</creator><creator>LIN, Kuo-Sin</creator><creator>CHEN, Jong-Dar</creator><creator>FU, Cheng-Chung</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients</title><author>CHERN, Jimmy P. S ; LIN, Kai-Hsin ; LU, Meng-Yao ; LIN, Dong-Tsam ; LIN, Kuo-Sin ; CHEN, Jong-Dar ; FU, Cheng-Chung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-235590ca955317c125c65e1d1f4ddf3e9c5cb4cd1aa18f66aedbb382776e895e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Abnormalities</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Anemias. Hemoglobinopathies</topic><topic>beta-Thalassemia - blood</topic><topic>beta-Thalassemia - complications</topic><topic>beta-Thalassemia - therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Transfusion</topic><topic>Child</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diseases of red blood cells</topic><topic>Female</topic><topic>Ferritins - blood</topic><topic>Glucose</topic><topic>Glucose Intolerance - epidemiology</topic><topic>Glucose metabolism</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hepatitis</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis C - epidemiology</topic><topic>Humans</topic><topic>Iron</topic><topic>Iron Chelating Agents - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Patient Compliance</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Taiwan</topic><topic>Thalassemia</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHERN, Jimmy P. S</creatorcontrib><creatorcontrib>LIN, Kai-Hsin</creatorcontrib><creatorcontrib>LU, Meng-Yao</creatorcontrib><creatorcontrib>LIN, Dong-Tsam</creatorcontrib><creatorcontrib>LIN, Kuo-Sin</creatorcontrib><creatorcontrib>CHEN, Jong-Dar</creatorcontrib><creatorcontrib>FU, Cheng-Chung</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHERN, Jimmy P. S</au><au>LIN, Kai-Hsin</au><au>LU, Meng-Yao</au><au>LIN, Dong-Tsam</au><au>LIN, Kuo-Sin</au><au>CHEN, Jong-Dar</au><au>FU, Cheng-Chung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>24</volume><issue>5</issue><spage>850</spage><epage>854</epage><pages>850-854</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients
Jimmy P.S. Chern , MD 1 ,
Kai-Hsin Lin , MD 2 ,
Meng-Yao Lu , MD 2 ,
Dong-Tsam Lin , MD 2 ,
Kuo-Sin Lin , MD, PHD 2 ,
Jong-Dar Chen , MD 1 and
Cheng-Chung Fu , MD 1
1 Department of Family Medicine, Tao-Yuan Hospital, Department of Health, Tao-Yuan
2 Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
Abstract
OBJECTIVE —To study the prevalence of and risk factors for abnormal glucose tolerance in transfusion-dependent β-thalassemic patients.
RESEARCH DESIGN AND METHODS —A total of 89 transfusion-dependent β-thalassemic patients were interviewed. Diabetes was previously diagnosed in 14 of them.
In the remaining 75 patients, 68 participated in an oral glucose tolerance test. Potential risk factors were identified using
the independent t test, χ 2 test, and Fisher’s exact test. Logistic regression analysis was used to select the independent risk factors that best predicted
abnormal glucose tolerance. A two-tailed P value of <0.05 was considered to be statistically significant.
RESULTS —The prevalence of impaired glucose tolerance was 8.5% (7 of 82) and that of diabetes was 19.5% (16 of 82). Presentation with
diabetic ketoacidosis was 31.1% (5 of 16). The risk factors for abnormal glucose tolerance found in transfusion-dependent
β-thalassemic patients were serum ferritin concentration and hepatitis C infection.
CONCLUSIONS —The interaction of iron overload and hepatitis C infection worsened the prognosis of thalassemic patients. Aggressive iron-chelation
therapy as well as prevention and treatment of hepatitis C infection should be mandatory in managing glucose homeostasis in
transfusion-dependent β-thalassemic patients in Taiwan.
ADA, American Diabetes Association
IGT, impaired glucose tolerance
OGTT, oral glucose tolerance test
OR, odds ratio
Footnotes
Address correspondence and reprint requests to Kai-Hsin Lin, MD, National Taiwan University Hospital, No. 7, Chungshan S.
Rd., Taipei, Taiwan, 10016, R.O.C. E-mail: link{at}ha.mc.ntu.edu.tw .
Received for publication 3 July 2000 and accepted in revised form 18 January 2001.
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>11347742</pmid><doi>10.2337/diacare.24.5.850</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2001-05, Vol.24 (5), p.850-854 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Abnormalities Adolescent Adult Anemias. Hemoglobinopathies beta-Thalassemia - blood beta-Thalassemia - complications beta-Thalassemia - therapy Biological and medical sciences Blood Transfusion Child Complications and side effects Diabetes Diabetes Mellitus - epidemiology Diseases of red blood cells Female Ferritins - blood Glucose Glucose Intolerance - epidemiology Glucose metabolism Hematologic and hematopoietic diseases Hepatitis Hepatitis B - epidemiology Hepatitis C - epidemiology Humans Iron Iron Chelating Agents - therapeutic use Male Medical sciences Patient Compliance Prevalence Risk Factors Taiwan Thalassemia Tropical medicine |
| title | Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients |
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