Altered Fiber Distribution and Fiber-Specific Glycolytic and Oxidative Enzyme Activity in Skeletal Muscle of Patients With Type 2 Diabetes

OBJECTIVE:--We investigated whether alterations of glycolytic and oxidative enzyme capacity in skeletal muscle of patients with type 2 diabetes pertain to specific muscle fibers and are associated with changes in muscle fiber composition. RESEARCH DESIGN AND METHODS--Vastus lateralis muscle was obta...

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Veröffentlicht in:	Diabetes care 2006-04, Vol.29 (4), p.895-900
Hauptverfasser:	Oberbach, Andreas, Bossenz, Yvonne, Lehmann, Stefanie, Niebauer, Josef, Adams, Volker, Paschke, Ralf, Schön, Michael R, Blüher, Matthias, Punkt, Karla
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Biological and medical sciences Diabetes Diabetes Mellitus, Type 2 - enzymology Diabetes. Impaired glucose tolerance Drug resistance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme activation Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucose - metabolism Glycerolphosphate Dehydrogenase - metabolism Glycolysis Humans Insulin L-Lactate Dehydrogenase - metabolism Male Medical sciences Metabolism Middle Aged Muscle Fibers, Fast-Twitch - enzymology Muscle Fibers, Fast-Twitch - pathology Muscle Fibers, Slow-Twitch - enzymology Muscle Fibers, Slow-Twitch - pathology Muscles Muscular system Oxidation-Reduction Oxygen Consumption - physiology Quadriceps Muscle - enzymology Succinate Dehydrogenase - metabolism Type 2 diabetes
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