Synthesis and biological relevance of N-acetylglucosamine-containing oligosaccharides

Synthesis and biological relevance of N-acetylglucosamine-containing oligosaccharides

The structural diversity as well as the biological significance of -acetylglucosamine-containing glycans are exemplified. The problem of forming the respective glycosidic bonds of synthetic targets is addressed. Special emphasis has been given to human milk oligosaccharides (HMOs), in view of their...

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Veröffentlicht in:Pure and applied chemistry 2007-12, Vol.79 (12), p.2229-2242
Hauptverfasser: El Ashry, El Sayed H., Aly, Mohamed R. E.
Format: Artikel
Sprache:eng
Schlagworte:
Biodiversity
dimethylmaleoyl
glycans
glycoconjugates
glycoforms
human milk oligosaccharides
N-acetylglucosamine
Oligosaccharides
protecting groups
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Zusammenfassung:The structural diversity as well as the biological significance of -acetylglucosamine-containing glycans are exemplified. The problem of forming the respective glycosidic bonds of synthetic targets is addressed. Special emphasis has been given to human milk oligosaccharides (HMOs), in view of their biological relevance, and synthetic approaches of selected examples are reported.
ISSN:0033-4545
1365-3075
DOI:10.1351/pac200779122229