Biosynthetic system of camptothecin: An anticancer plant product
Camptothecin is one of the clinically used anticancer compounds derived from plants. We have established a hairy root culture , which efficiently produces camptothecin. The strictosidine synthase cDNA was obtained from , and its properties were characterized using recombinant protein expressed in ....
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| Veröffentlicht in: | Pure and applied chemistry 2010-01, Vol.82 (1), p.213-218 |
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| container_end_page | 218 |
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| container_title | Pure and applied chemistry |
| container_volume | 82 |
| creator | Yamazaki, Mami Asano, Takashi Yamazaki, Yasuyo Sirikantaramas, Supaart Sudo, Hiroshi Saito, Kazuki |
| description | Camptothecin is one of the clinically used anticancer compounds derived from plants. We have established a hairy root culture
, which efficiently produces camptothecin. The strictosidine synthase cDNA was obtained from
, and its properties were characterized using recombinant protein expressed in
. The mechanisms of camptothecin transport and self-resistance of producing plant cells have also been investigated. These studies offer a basis for pathway engineering of camptothecin in the future. |
| doi_str_mv | 10.1351/PAC-CON-09-02-08 |
| format | Article |
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, which efficiently produces camptothecin. The strictosidine synthase cDNA was obtained from
, and its properties were characterized using recombinant protein expressed in
. The mechanisms of camptothecin transport and self-resistance of producing plant cells have also been investigated. These studies offer a basis for pathway engineering of camptothecin in the future.</description><identifier>ISSN: 0033-4545</identifier><identifier>EISSN: 1365-3075</identifier><identifier>DOI: 10.1351/PAC-CON-09-02-08</identifier><language>eng</language><publisher>Berlin: De Gruyter</publisher><subject>anticancer alkaloids ; camptothecin ; Cancer ; E coli ; hairy roots ; strictosidine synthase</subject><ispartof>Pure and applied chemistry, 2010-01, Vol.82 (1), p.213-218</ispartof><rights>2013 Walter de Gruyter GmbH, Berlin/Boston</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-b2aa98f6af1bd9117d95fa6904733ea103bc4cfa37fc12bc1845c7befeea848a3</citedby><cites>FETCH-LOGICAL-c434t-b2aa98f6af1bd9117d95fa6904733ea103bc4cfa37fc12bc1845c7befeea848a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Yamazaki, Mami</creatorcontrib><creatorcontrib>Asano, Takashi</creatorcontrib><creatorcontrib>Yamazaki, Yasuyo</creatorcontrib><creatorcontrib>Sirikantaramas, Supaart</creatorcontrib><creatorcontrib>Sudo, Hiroshi</creatorcontrib><creatorcontrib>Saito, Kazuki</creatorcontrib><title>Biosynthetic system of camptothecin: An anticancer plant product</title><title>Pure and applied chemistry</title><description>Camptothecin is one of the clinically used anticancer compounds derived from plants. We have established a hairy root culture
, which efficiently produces camptothecin. The strictosidine synthase cDNA was obtained from
, and its properties were characterized using recombinant protein expressed in
. The mechanisms of camptothecin transport and self-resistance of producing plant cells have also been investigated. These studies offer a basis for pathway engineering of camptothecin in the future.</description><subject>anticancer alkaloids</subject><subject>camptothecin</subject><subject>Cancer</subject><subject>E coli</subject><subject>hairy roots</subject><subject>strictosidine synthase</subject><issn>0033-4545</issn><issn>1365-3075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKxDAUhoMoOI7uXRZcR09y0mniQhyLNxgcF7oOaZpoZaatSYv07Y2M4MrVufBf4CPklME5w5xdPC9LWq6fKCgKnILcIzOGi5wiFPk-mQEgUpGL_JAcxfgBAEIJPiPXN00Xp3Z4d0NjszjFwW2zzmfWbPuhS2_btJfZss1MmwSmtS5k_SYdWR-6erTDMTnwZhPdye-ck9e725fyga7W94_lckWtQDHQihujpF8Yz6paMVbUKvdmoUAUiM4wwMoK6w0W3jJeWSZFbovKeeeMFNLgnJztclPv5-jioD-6MbSpUnOOwCWCwqSCncqGLsbgvO5DszVh0gz0DyedOOnESYPSwDXIZLnaWb7MZnChdm9hnNLyl_-fVXLGGeI31NZwbw</recordid><startdate>20100103</startdate><enddate>20100103</enddate><creator>Yamazaki, Mami</creator><creator>Asano, Takashi</creator><creator>Yamazaki, Yasuyo</creator><creator>Sirikantaramas, Supaart</creator><creator>Sudo, Hiroshi</creator><creator>Saito, Kazuki</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20100103</creationdate><title>Biosynthetic system of camptothecin: An anticancer plant product</title><author>Yamazaki, Mami ; Asano, Takashi ; Yamazaki, Yasuyo ; Sirikantaramas, Supaart ; Sudo, Hiroshi ; Saito, Kazuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-b2aa98f6af1bd9117d95fa6904733ea103bc4cfa37fc12bc1845c7befeea848a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>anticancer alkaloids</topic><topic>camptothecin</topic><topic>Cancer</topic><topic>E coli</topic><topic>hairy roots</topic><topic>strictosidine synthase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamazaki, Mami</creatorcontrib><creatorcontrib>Asano, Takashi</creatorcontrib><creatorcontrib>Yamazaki, Yasuyo</creatorcontrib><creatorcontrib>Sirikantaramas, Supaart</creatorcontrib><creatorcontrib>Sudo, Hiroshi</creatorcontrib><creatorcontrib>Saito, Kazuki</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Pure and applied chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamazaki, Mami</au><au>Asano, Takashi</au><au>Yamazaki, Yasuyo</au><au>Sirikantaramas, Supaart</au><au>Sudo, Hiroshi</au><au>Saito, Kazuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biosynthetic system of camptothecin: An anticancer plant product</atitle><jtitle>Pure and applied chemistry</jtitle><date>2010-01-03</date><risdate>2010</risdate><volume>82</volume><issue>1</issue><spage>213</spage><epage>218</epage><pages>213-218</pages><issn>0033-4545</issn><eissn>1365-3075</eissn><abstract>Camptothecin is one of the clinically used anticancer compounds derived from plants. We have established a hairy root culture
, which efficiently produces camptothecin. The strictosidine synthase cDNA was obtained from
, and its properties were characterized using recombinant protein expressed in
. The mechanisms of camptothecin transport and self-resistance of producing plant cells have also been investigated. These studies offer a basis for pathway engineering of camptothecin in the future.</abstract><cop>Berlin</cop><pub>De Gruyter</pub><doi>10.1351/PAC-CON-09-02-08</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pure and applied chemistry, 2010-01, Vol.82 (1), p.213-218 |
| issn | 0033-4545 1365-3075 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | anticancer alkaloids camptothecin Cancer E coli hairy roots strictosidine synthase |
| title | Biosynthetic system of camptothecin: An anticancer plant product |
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