Porphyrins as spectroscopic sensors for conformational studies of DNA
Molecular systems containing two or more interacting porphyrins show remarkable spectroscopic features that allow for a very sensitive detection of conformational changes on the microscale level by different methods, such as fluorescence and electronic circular dichroism (ECD). Covalent porphyrin-DN...
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| Veröffentlicht in: | Pure and applied chemistry 2007-04, Vol.79 (4), p.801-809 |
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| container_title | Pure and applied chemistry |
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| creator | Balaz, Milan Bitsch-Jensen, Klaus Mammana, Angela Ellestad, George A. Nakanishi, Koji Berova, Nina |
| description | Molecular systems containing two or more interacting porphyrins show remarkable spectroscopic features that allow for a very sensitive detection of conformational changes on the microscale level by different methods, such as fluorescence and electronic circular dichroism (ECD). Covalent porphyrin-DNA assemblies can provide a CD profile (exciton couplet) within the porphyrin Soret band region which is very diagnostic for DNA conformational changes. Additionally, covalently linked porphyrins have been shown to function as DNA molecular caps and to stabilize the non-self-complementary non-Watson-Crick guanine-adenine DNA sequence via their strong π-π stacking. |
| doi_str_mv | 10.1351/pac200779040801 |
| format | Article |
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Additionally, covalently linked porphyrins have been shown to function as DNA molecular caps and to stabilize the non-self-complementary non-Watson-Crick guanine-adenine DNA sequence via their strong π-π stacking.</description><subject>B- to Z-DNA transition</subject><subject>Change detection</subject><subject>circular dichroism</subject><subject>Deoxyribonucleic acid</subject><subject>Diagnostic systems</subject><subject>Dichroism</subject><subject>DNA</subject><subject>DNA conformation</subject><subject>DNA conjugates</subject><subject>DNA probe</subject><subject>Excitons</subject><subject>Fluorescence</subject><subject>oligonucleotides</subject><subject>Porphyrins</subject><issn>0033-4545</issn><issn>1365-3075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp1kM1Lw0AUxBdRsFbPXhc8x779ymYPHkqtH1DUg57DZnejKW027kuQ_vemVBAETzOH-Q3vDSGXDK6ZUGzWWccBtDYgoQB2RCZM5CoToNUxmQAIkUkl1Sk5Q1wDgDSST8jyJabuY5eaFqlFil1wfYroYtc4iqHFmJDWMVEX21G2tm9iazcU-8E3AWms6e3T_Jyc1HaD4eJHp-Ttbvm6eMhWz_ePi_kqcyKXfRYUryTTnBWVMapWwWlb5do4rapQGwdSM-G5ZqGQxgVmisIzqWXhha98xcWUXB16uxQ_h4B9uY5DGu_BknMBTAil8jE1O6Tc-AmmUJddarY27UoG5X6r8s9WI3FzIL7spg_Jh_c07EbzW_8PqY3c89_I3G-9</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Balaz, Milan</creator><creator>Bitsch-Jensen, Klaus</creator><creator>Mammana, Angela</creator><creator>Ellestad, George A.</creator><creator>Nakanishi, Koji</creator><creator>Berova, Nina</creator><general>De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20070401</creationdate><title>Porphyrins as spectroscopic sensors for conformational studies of DNA</title><author>Balaz, Milan ; Bitsch-Jensen, Klaus ; Mammana, Angela ; Ellestad, George A. ; Nakanishi, Koji ; Berova, Nina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-e52b417218b995f5ec7ab679c75bef9c04713d271e849ce1988d14748d3dbdb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>B- to Z-DNA transition</topic><topic>Change detection</topic><topic>circular dichroism</topic><topic>Deoxyribonucleic acid</topic><topic>Diagnostic systems</topic><topic>Dichroism</topic><topic>DNA</topic><topic>DNA conformation</topic><topic>DNA conjugates</topic><topic>DNA probe</topic><topic>Excitons</topic><topic>Fluorescence</topic><topic>oligonucleotides</topic><topic>Porphyrins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balaz, Milan</creatorcontrib><creatorcontrib>Bitsch-Jensen, Klaus</creatorcontrib><creatorcontrib>Mammana, Angela</creatorcontrib><creatorcontrib>Ellestad, George A.</creatorcontrib><creatorcontrib>Nakanishi, Koji</creatorcontrib><creatorcontrib>Berova, Nina</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Pure and applied chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balaz, Milan</au><au>Bitsch-Jensen, Klaus</au><au>Mammana, Angela</au><au>Ellestad, George A.</au><au>Nakanishi, Koji</au><au>Berova, Nina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porphyrins as spectroscopic sensors for conformational studies of DNA</atitle><jtitle>Pure and applied chemistry</jtitle><date>2007-04-01</date><risdate>2007</risdate><volume>79</volume><issue>4</issue><spage>801</spage><epage>809</epage><pages>801-809</pages><issn>0033-4545</issn><eissn>1365-3075</eissn><abstract>Molecular systems containing two or more interacting porphyrins show remarkable spectroscopic features that allow for a very sensitive detection of conformational changes on the microscale level by different methods, such as fluorescence and electronic circular dichroism (ECD). 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| ispartof | Pure and applied chemistry, 2007-04, Vol.79 (4), p.801-809 |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | B- to Z-DNA transition Change detection circular dichroism Deoxyribonucleic acid Diagnostic systems Dichroism DNA DNA conformation DNA conjugates DNA probe Excitons Fluorescence oligonucleotides Porphyrins |
| title | Porphyrins as spectroscopic sensors for conformational studies of DNA |
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