Clinical trial evaluating the effectiveness of biocompound IMMUNEPOTENT CRP in the third-molar extraction
A controlled, parallel, randomized and comparative trial was carried out to evaluate the anti-inflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar surgery over seven days. The anti-inflammatory efficacy of IMMUNEPOTENT CRP was evaluated using the method of Amin an...
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| Veröffentlicht in: | Biotechnology, biotechnological equipment biotechnological equipment, 2017-01, Vol.31 (1), p.182-186 |
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| creator | Franco-Molina, Moises A. Mendoza-Gamboa, Edgar Coronado-Cerda, Erika E. Zarate-Triviño, Diana Arizpe-Coronado, Juan E. Zapata-Benavides, Pablo Ramos Zayas, Yareellys Tamez-Guerra, Reyes Rodríguez-Padilla, Cristina |
| description | A controlled, parallel, randomized and comparative trial was carried out to evaluate the anti-inflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar surgery over seven days. The anti-inflammatory efficacy of IMMUNEPOTENT CRP was evaluated using the method of Amin and Laskin, and the analysis of cytokine production (IL-2, IL-4, IL-6, IL-10, TNF-α, INF-γ) in saliva was done by flow cytometry. The swelling process after surgery was significant (p < 0.05) and the treatments with IMMUNEPOTENT CRP or ibuprofen controlled this process properly; no difference between the groups was found (p < 0.05). Both treatments were shown to modulate the cytokine production. These results demonstrate the anti-inflammatory activity of the natural compound IMMUNEPOTENT CRP and suggest it could be used in clinical dental practice. |
| doi_str_mv | 10.1080/13102818.2016.1249408 |
| format | Article |
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These results demonstrate the anti-inflammatory activity of the natural compound IMMUNEPOTENT CRP and suggest it could be used in clinical dental practice.</description><identifier>ISSN: 1310-2818</identifier><identifier>EISSN: 1314-3530</identifier><identifier>DOI: 10.1080/13102818.2016.1249408</identifier><language>eng</language><publisher>Sofia: Taylor & Francis</publisher><subject>Anti-inflammatory agents ; Clinical trials ; cytokine ; Cytokines ; Flow cytometry ; Ibuprofen ; IMMUNEPOTENT CRP ; Inflammation ; Interleukin 10 ; Interleukin 2 ; Interleukin 4 ; Interleukin 6 ; Nonsteroidal anti-inflammatory drugs ; Saliva ; Surgery ; Tumor necrosis factor-α</subject><ispartof>Biotechnology, biotechnological equipment, 2017-01, Vol.31 (1), p.182-186</ispartof><rights>2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2016</rights><rights>2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 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These results demonstrate the anti-inflammatory activity of the natural compound IMMUNEPOTENT CRP and suggest it could be used in clinical dental practice.</description><subject>Anti-inflammatory agents</subject><subject>Clinical trials</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Flow cytometry</subject><subject>Ibuprofen</subject><subject>IMMUNEPOTENT CRP</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin 2</subject><subject>Interleukin 4</subject><subject>Interleukin 6</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Saliva</subject><subject>Surgery</subject><subject>Tumor necrosis factor-α</subject><issn>1310-2818</issn><issn>1314-3530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNp9kVtvEzEQhVcIJErhJyBZ4nnD-Jb1voGiAJF6E0qfrVmv3Tra2MF2WvrvcZLSx76Mx6NzvhnpNM1nCjMKCr5SToEpqmYM6HxGmegFqDfNWZ2LlksOb489tAfR--ZDzhuADoB2Z41fTD54gxMpyddqH3DaY_HhjpR7S6xz1hT_YIPNmURHBh9N3O7iPoxkdXl5e7W8uV4vr9Zk8fuG-HA0lXufxnYbJ0zE_i0JKyGGj807h1O2n57f8-b2x3K9-NVeXP9cLb5ftEYyWlqqnBVKzJlTDqUdjbWOSmFwdB0VPWe9Aia5GZxjAzIjUCAfYaD1R10P_LxZnbhjxI3eJb_F9KQjen0cxHSnMRVvJqs5SKiofpB8LhzrepTUdDhyy01X76isLyfWLsU_e5uL3sR9CvV8zRjr54KDUlUlTyqTYs7JupetFPQhIf0_IX1ISD8nVH3fTj4fXExbfIxpGnXBpykmlzAYnzV_HfEPjSuXcw</recordid><startdate>20170102</startdate><enddate>20170102</enddate><creator>Franco-Molina, Moises A.</creator><creator>Mendoza-Gamboa, Edgar</creator><creator>Coronado-Cerda, Erika E.</creator><creator>Zarate-Triviño, Diana</creator><creator>Arizpe-Coronado, Juan E.</creator><creator>Zapata-Benavides, Pablo</creator><creator>Ramos Zayas, Yareellys</creator><creator>Tamez-Guerra, Reyes</creator><creator>Rodríguez-Padilla, Cristina</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7ST</scope><scope>7XB</scope><scope>8FD</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>SOI</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5469-8449</orcidid></search><sort><creationdate>20170102</creationdate><title>Clinical trial evaluating the effectiveness of biocompound IMMUNEPOTENT CRP in the third-molar extraction</title><author>Franco-Molina, Moises A. ; Mendoza-Gamboa, Edgar ; Coronado-Cerda, Erika E. ; Zarate-Triviño, Diana ; Arizpe-Coronado, Juan E. ; Zapata-Benavides, Pablo ; Ramos Zayas, Yareellys ; Tamez-Guerra, Reyes ; Rodríguez-Padilla, Cristina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-18fe48462f8fa5edceef154cadf714932980253cbff2ba2c4a4a3d0b12ba1f903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anti-inflammatory agents</topic><topic>Clinical trials</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Flow cytometry</topic><topic>Ibuprofen</topic><topic>IMMUNEPOTENT CRP</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin 2</topic><topic>Interleukin 4</topic><topic>Interleukin 6</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Saliva</topic><topic>Surgery</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franco-Molina, Moises A.</creatorcontrib><creatorcontrib>Mendoza-Gamboa, Edgar</creatorcontrib><creatorcontrib>Coronado-Cerda, Erika E.</creatorcontrib><creatorcontrib>Zarate-Triviño, Diana</creatorcontrib><creatorcontrib>Arizpe-Coronado, Juan E.</creatorcontrib><creatorcontrib>Zapata-Benavides, Pablo</creatorcontrib><creatorcontrib>Ramos Zayas, Yareellys</creatorcontrib><creatorcontrib>Tamez-Guerra, Reyes</creatorcontrib><creatorcontrib>Rodríguez-Padilla, Cristina</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Biotechnology, biotechnological equipment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franco-Molina, Moises A.</au><au>Mendoza-Gamboa, Edgar</au><au>Coronado-Cerda, Erika E.</au><au>Zarate-Triviño, Diana</au><au>Arizpe-Coronado, Juan E.</au><au>Zapata-Benavides, Pablo</au><au>Ramos Zayas, Yareellys</au><au>Tamez-Guerra, Reyes</au><au>Rodríguez-Padilla, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical trial evaluating the effectiveness of biocompound IMMUNEPOTENT CRP in the third-molar extraction</atitle><jtitle>Biotechnology, biotechnological equipment</jtitle><date>2017-01-02</date><risdate>2017</risdate><volume>31</volume><issue>1</issue><spage>182</spage><epage>186</epage><pages>182-186</pages><issn>1310-2818</issn><eissn>1314-3530</eissn><abstract>A controlled, parallel, randomized and comparative trial was carried out to evaluate the anti-inflammatory efficacy of IMMUNEPOTENT CRP versus ibuprofen in patients after third-molar surgery over seven days. The anti-inflammatory efficacy of IMMUNEPOTENT CRP was evaluated using the method of Amin and Laskin, and the analysis of cytokine production (IL-2, IL-4, IL-6, IL-10, TNF-α, INF-γ) in saliva was done by flow cytometry. The swelling process after surgery was significant (p < 0.05) and the treatments with IMMUNEPOTENT CRP or ibuprofen controlled this process properly; no difference between the groups was found (p < 0.05). Both treatments were shown to modulate the cytokine production. These results demonstrate the anti-inflammatory activity of the natural compound IMMUNEPOTENT CRP and suggest it could be used in clinical dental practice.</abstract><cop>Sofia</cop><pub>Taylor & Francis</pub><doi>10.1080/13102818.2016.1249408</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-5469-8449</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-inflammatory agents Clinical trials cytokine Cytokines Flow cytometry Ibuprofen IMMUNEPOTENT CRP Inflammation Interleukin 10 Interleukin 2 Interleukin 4 Interleukin 6 Nonsteroidal anti-inflammatory drugs Saliva Surgery Tumor necrosis factor-α |
| title | Clinical trial evaluating the effectiveness of biocompound IMMUNEPOTENT CRP in the third-molar extraction |
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