Homeotic DUX4 Genes that Control Human Embryonic Development at the Two-Cell Stage Are Surrounded by Regions Contacting with rDNA Gene Clusters
Many human genes that control human embryonic development and differentiation of human cells form chromosomal contact with rRNA gene clusters, which are involved in the epigenetic regulation of many genes. The sites of rRNA gene contact often fall on extended (up to 50 kb) regions containing a chrom...
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| Veröffentlicht in: | Molecular biology (New York) 2019-03, Vol.53 (2), p.237-241 |
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| creator | Kretova, O. V. Fedoseeva, D. M. Kravatsky, Y. V. Alembekov, I. R. Slovohotov, I. Y. Tchurikov, N. A. |
| description | Many human genes that control human embryonic development and differentiation of human cells form chromosomal contact with rRNA gene clusters, which are involved in the epigenetic regulation of many genes. The sites of rRNA gene contact often fall on extended (up to 50 kb) regions containing a chromatin mark, H3K27ac histone, typical for superenhancers, as well as on pericentromeric and subtelomeric regions of chromosomes. We found that the
DUX4
genes located in the subtelomeric region of human chromosome 4 are surrounded by regions that are often in contact with the rRNA genes. The 25 kb region of this chromosome, presented in version hg19 of the sequenced human genome, contains several copies of the
DUX4
gene. The sites of rRNA gene contacts located around this region contain methylation sites as well as CTCF binding sites. It is assumed that the rRNA gene contacts are important in silencing these
DUX4
gene copies. |
| doi_str_mv | 10.1134/S0026893319020080 |
| format | Article |
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DUX4
genes located in the subtelomeric region of human chromosome 4 are surrounded by regions that are often in contact with the rRNA genes. The 25 kb region of this chromosome, presented in version hg19 of the sequenced human genome, contains several copies of the
DUX4
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DUX4
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DUX4
genes located in the subtelomeric region of human chromosome 4 are surrounded by regions that are often in contact with the rRNA genes. The 25 kb region of this chromosome, presented in version hg19 of the sequenced human genome, contains several copies of the
DUX4
gene. The sites of rRNA gene contacts located around this region contain methylation sites as well as CTCF binding sites. It is assumed that the rRNA gene contacts are important in silencing these
DUX4
gene copies.</description><subject>Binding sites</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Chromatin</subject><subject>Chromosome 4</subject><subject>Chromosomes</subject><subject>Developmental stages</subject><subject>DNA methylation</subject><subject>Embryogenesis</subject><subject>Embryonic growth stage</subject><subject>Gene clusters</subject><subject>Gene regulation</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics. 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DUX4
genes located in the subtelomeric region of human chromosome 4 are surrounded by regions that are often in contact with the rRNA genes. The 25 kb region of this chromosome, presented in version hg19 of the sequenced human genome, contains several copies of the
DUX4
gene. The sites of rRNA gene contacts located around this region contain methylation sites as well as CTCF binding sites. It is assumed that the rRNA gene contacts are important in silencing these
DUX4
gene copies.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S0026893319020080</doi><tpages>5</tpages></addata></record> |
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| subjects | Binding sites Biochemistry Biomedical and Life Sciences Chromatin Chromosome 4 Chromosomes Developmental stages DNA methylation Embryogenesis Embryonic growth stage Gene clusters Gene regulation Genes Genomes Genomics. Transcriptomics Human Genetics Life Sciences rRNA |
| title | Homeotic DUX4 Genes that Control Human Embryonic Development at the Two-Cell Stage Are Surrounded by Regions Contacting with rDNA Gene Clusters |
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