A new therapeutic approach to type II leprosy reaction
Background An increase in tumor necrosis factor (TNF) has been implicated in type II leprosy reaction. Thalidomide, which inhibits TNF, is an effective drug, but has severe side‐effects in pregnant women. Other therapeutic drugs are required. Methods Clofazimine and pentoxifylline were evaluated for...
Gespeichert in:
| Veröffentlicht in: | International journal of dermatology 1999-12, Vol.38 (12), p.931-933 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 933 |
|---|---|
| container_issue | 12 |
| container_start_page | 931 |
| container_title | International journal of dermatology |
| container_volume | 38 |
| creator | Welsh, Oliverio Gómez, Minerva Mancias, Cecilia Ibarra-Leal, Sara Millikan, Larry E. |
| description | Background An increase in tumor necrosis factor (TNF) has been implicated in type II leprosy reaction. Thalidomide, which inhibits TNF, is an effective drug, but has severe side‐effects in pregnant women. Other therapeutic drugs are required.
Methods Clofazimine and pentoxifylline were evaluated for their efficacy against severe type II leprosy reaction in four patients (three men and one woman).
Results All four patients showed a similar fast response to treatment.
Conclusions The results obtained in this study are promising; however, clofazimine and pentoxifylline must be evaluated in a larger group of patients in order to determine their value in controlling type II leprosy reaction. |
| doi_str_mv | 10.1046/j.1365-4362.1999.00755.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_222917974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>50232219</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5535-7e9576aa5ad720481dfcc5bcd6d462e5cb11fabe297c40358212668a5dc7699b3</originalsourceid><addsrcrecordid>eNqNkMlOwzAURS0EomX4BWQhtgkeYjuW2JQCbVEFmwISG8txHDWlQ7BTtfl7XFIBS1aezr3POgBAjGKMEn49izHlLEooJzGWUsYICcbi7QHotg-ckkPQRQjjSCImO-DE-1k4UoKTY9DBKABCiC7gPbi0G1hPrdOVXdelgbqq3EqbKaxXsG4qC0cjOLfhzjfQWW3qcrU8A0eFnnt7vl9PwcvD_aQ_jMbPg1G_N44MY5RFwkomuNZM54KgJMV5YQzLTM7zhBPLTIZxoTNLpDAJoiwlmHCeapYbwaXM6Cm4bHvD-M-19bWardZuGUYqQojEQookQGkLmfBH72yhKlcutGsURmrnS83UTova-VI7X-rbl9qG6MW-f50tbP4n2AoKwNUe0N7oeeH00pT-lyOhkrKA3bTYppzb5t_z1ejxLmxCPGrjpa_t9ieu3Yfiggqm3p4GKhWT9-EwvVWv9Au7E5M4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222917974</pqid></control><display><type>article</type><title>A new therapeutic approach to type II leprosy reaction</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Welsh, Oliverio ; Gómez, Minerva ; Mancias, Cecilia ; Ibarra-Leal, Sara ; Millikan, Larry E.</creator><creatorcontrib>Welsh, Oliverio ; Gómez, Minerva ; Mancias, Cecilia ; Ibarra-Leal, Sara ; Millikan, Larry E.</creatorcontrib><description>Background An increase in tumor necrosis factor (TNF) has been implicated in type II leprosy reaction. Thalidomide, which inhibits TNF, is an effective drug, but has severe side‐effects in pregnant women. Other therapeutic drugs are required.
Methods Clofazimine and pentoxifylline were evaluated for their efficacy against severe type II leprosy reaction in four patients (three men and one woman).
Results All four patients showed a similar fast response to treatment.
Conclusions The results obtained in this study are promising; however, clofazimine and pentoxifylline must be evaluated in a larger group of patients in order to determine their value in controlling type II leprosy reaction.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1046/j.1365-4362.1999.00755.x</identifier><identifier>PMID: 10632777</identifier><identifier>CODEN: IJDEBB</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Biological and medical sciences ; Clofazimine - administration & dosage ; Drug Therapy, Combination ; Erythema Nodosum - drug therapy ; Erythema Nodosum - pathology ; Female ; Human bacterial diseases ; Humans ; Infectious diseases ; Leprostatic Agents - administration & dosage ; Leprosy ; Leprosy, Lepromatous - drug therapy ; Leprosy, Lepromatous - pathology ; Male ; Medical sciences ; Middle Aged ; Pentoxifylline - administration & dosage ; Pharmacology. Drug treatments ; Tropical bacterial diseases ; Tropical medicine</subject><ispartof>International journal of dermatology, 1999-12, Vol.38 (12), p.931-933</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Ltd. Dec 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5535-7e9576aa5ad720481dfcc5bcd6d462e5cb11fabe297c40358212668a5dc7699b3</citedby><cites>FETCH-LOGICAL-c5535-7e9576aa5ad720481dfcc5bcd6d462e5cb11fabe297c40358212668a5dc7699b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-4362.1999.00755.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-4362.1999.00755.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1236235$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10632777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Welsh, Oliverio</creatorcontrib><creatorcontrib>Gómez, Minerva</creatorcontrib><creatorcontrib>Mancias, Cecilia</creatorcontrib><creatorcontrib>Ibarra-Leal, Sara</creatorcontrib><creatorcontrib>Millikan, Larry E.</creatorcontrib><title>A new therapeutic approach to type II leprosy reaction</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background An increase in tumor necrosis factor (TNF) has been implicated in type II leprosy reaction. Thalidomide, which inhibits TNF, is an effective drug, but has severe side‐effects in pregnant women. Other therapeutic drugs are required.
Methods Clofazimine and pentoxifylline were evaluated for their efficacy against severe type II leprosy reaction in four patients (three men and one woman).
Results All four patients showed a similar fast response to treatment.
Conclusions The results obtained in this study are promising; however, clofazimine and pentoxifylline must be evaluated in a larger group of patients in order to determine their value in controlling type II leprosy reaction.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Clofazimine - administration & dosage</subject><subject>Drug Therapy, Combination</subject><subject>Erythema Nodosum - drug therapy</subject><subject>Erythema Nodosum - pathology</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Leprostatic Agents - administration & dosage</subject><subject>Leprosy</subject><subject>Leprosy, Lepromatous - drug therapy</subject><subject>Leprosy, Lepromatous - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pentoxifylline - administration & dosage</subject><subject>Pharmacology. Drug treatments</subject><subject>Tropical bacterial diseases</subject><subject>Tropical medicine</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAURS0EomX4BWQhtgkeYjuW2JQCbVEFmwISG8txHDWlQ7BTtfl7XFIBS1aezr3POgBAjGKMEn49izHlLEooJzGWUsYICcbi7QHotg-ckkPQRQjjSCImO-DE-1k4UoKTY9DBKABCiC7gPbi0G1hPrdOVXdelgbqq3EqbKaxXsG4qC0cjOLfhzjfQWW3qcrU8A0eFnnt7vl9PwcvD_aQ_jMbPg1G_N44MY5RFwkomuNZM54KgJMV5YQzLTM7zhBPLTIZxoTNLpDAJoiwlmHCeapYbwaXM6Cm4bHvD-M-19bWardZuGUYqQojEQookQGkLmfBH72yhKlcutGsURmrnS83UTova-VI7X-rbl9qG6MW-f50tbP4n2AoKwNUe0N7oeeH00pT-lyOhkrKA3bTYppzb5t_z1ejxLmxCPGrjpa_t9ieu3Yfiggqm3p4GKhWT9-EwvVWv9Au7E5M4</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>Welsh, Oliverio</creator><creator>Gómez, Minerva</creator><creator>Mancias, Cecilia</creator><creator>Ibarra-Leal, Sara</creator><creator>Millikan, Larry E.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>199912</creationdate><title>A new therapeutic approach to type II leprosy reaction</title><author>Welsh, Oliverio ; Gómez, Minerva ; Mancias, Cecilia ; Ibarra-Leal, Sara ; Millikan, Larry E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5535-7e9576aa5ad720481dfcc5bcd6d462e5cb11fabe297c40358212668a5dc7699b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Clofazimine - administration & dosage</topic><topic>Drug Therapy, Combination</topic><topic>Erythema Nodosum - drug therapy</topic><topic>Erythema Nodosum - pathology</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Leprostatic Agents - administration & dosage</topic><topic>Leprosy</topic><topic>Leprosy, Lepromatous - drug therapy</topic><topic>Leprosy, Lepromatous - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pentoxifylline - administration & dosage</topic><topic>Pharmacology. Drug treatments</topic><topic>Tropical bacterial diseases</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Welsh, Oliverio</creatorcontrib><creatorcontrib>Gómez, Minerva</creatorcontrib><creatorcontrib>Mancias, Cecilia</creatorcontrib><creatorcontrib>Ibarra-Leal, Sara</creatorcontrib><creatorcontrib>Millikan, Larry E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Welsh, Oliverio</au><au>Gómez, Minerva</au><au>Mancias, Cecilia</au><au>Ibarra-Leal, Sara</au><au>Millikan, Larry E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new therapeutic approach to type II leprosy reaction</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>1999-12</date><risdate>1999</risdate><volume>38</volume><issue>12</issue><spage>931</spage><epage>933</epage><pages>931-933</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><coden>IJDEBB</coden><abstract>Background An increase in tumor necrosis factor (TNF) has been implicated in type II leprosy reaction. Thalidomide, which inhibits TNF, is an effective drug, but has severe side‐effects in pregnant women. Other therapeutic drugs are required.
Methods Clofazimine and pentoxifylline were evaluated for their efficacy against severe type II leprosy reaction in four patients (three men and one woman).
Results All four patients showed a similar fast response to treatment.
Conclusions The results obtained in this study are promising; however, clofazimine and pentoxifylline must be evaluated in a larger group of patients in order to determine their value in controlling type II leprosy reaction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>10632777</pmid><doi>10.1046/j.1365-4362.1999.00755.x</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0011-9059 |
| ispartof | International journal of dermatology, 1999-12, Vol.38 (12), p.931-933 |
| issn | 0011-9059 1365-4632 |
| language | eng |
| recordid | cdi_proquest_journals_222917974 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Biological and medical sciences Clofazimine - administration & dosage Drug Therapy, Combination Erythema Nodosum - drug therapy Erythema Nodosum - pathology Female Human bacterial diseases Humans Infectious diseases Leprostatic Agents - administration & dosage Leprosy Leprosy, Lepromatous - drug therapy Leprosy, Lepromatous - pathology Male Medical sciences Middle Aged Pentoxifylline - administration & dosage Pharmacology. Drug treatments Tropical bacterial diseases Tropical medicine |
| title | A new therapeutic approach to type II leprosy reaction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T22%3A56%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20therapeutic%20approach%20to%20type%20II%20leprosy%20reaction&rft.jtitle=International%20journal%20of%20dermatology&rft.au=Welsh,%20Oliverio&rft.date=1999-12&rft.volume=38&rft.issue=12&rft.spage=931&rft.epage=933&rft.pages=931-933&rft.issn=0011-9059&rft.eissn=1365-4632&rft.coden=IJDEBB&rft_id=info:doi/10.1046/j.1365-4362.1999.00755.x&rft_dat=%3Cproquest_cross%3E50232219%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222917974&rft_id=info:pmid/10632777&rfr_iscdi=true |