New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles

The review summarizes the results obtained by our research group over the past 15 years in chemistry of N -, S , N -, and Se , N -heterocycles resulted from aminomethlation of a wide range of acyclic and heterocyclic substrates derived from active methylene amides, thioamides, and selenoamides. A series of 1,3,5-thia(selena)diazines, 3,7-diazabicyclo[3.3.1] nonanes, 3,5,7,11-tetraazatricyclo[7.3.1.0 2,7 ]tridec-2-enes, 1,3,5,7-tetrazocines, and pyrido[1,2- a ][1,3,5]triazines were synthesized. The general regularities of the Mannich reaction in the series of N -, S , N -, and Se , N -containing pyridine substrates were discussed. Biological activities of some synthesized compounds were studied to reveal compounds with antiviral, analeptic, anti-inflammatory, and antipyretic activities.