Immunohistochemistry of γ‐H2AX as a method of early detection of urinary bladder carcinogenicity in mice

Phosphorylated histone H2AX (γ‐H2AX) has been demonstrated as a DNA damage marker both in vitro and in vivo. We previously reported the effects of genotoxic carcinogens in the urinary bladder of rats by immunohistochemical analysis of γ‐H2AX using samples from 28‐day repeated‐dose tests. To evaluate...

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Veröffentlicht in:	Journal of applied toxicology 2019-06, Vol.39 (6), p.868-876
Hauptverfasser:	Sone, Mizuki, Toyoda, Takeshi, Cho, Young‐Man, Akagi, Jun‐ichi, Matsushita, Kohei, Mizuta, Yasuko, Morikawa, Tomomi, Nishikawa, Akiyoshi, Ogawa, Kumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamide Biocompatibility Biomarkers Bladder Carcinogenicity Carcinogens Cell proliferation Cytotoxicity Dimethylarsinic acid DNA damage early detection Genotoxicity Histone H2A Immunohistochemistry In vivo methods and tests Melamine Mice mouse Nitrosamine Organic chemistry Rodents Toxicity Uracil Urinary bladder Urothelium γ‐H2AX
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