Postnatal Changes in Plasma Ceruloplasmin and Transferrin Antioxidant Activities in Preterm Babies
Postnatal changes in plasma ceruloplasmin ferroxidase and transferrin iron-binding antioxidant activity were studied in 10 healthy preterm babies during the first 6 weeks of life. Ceruloplasmin levels and ceruloplasmin ferroxidase activity were low at birth, remained stable for the first 3 weeks, an...
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| Veröffentlicht in: | Biology of the neonate 2000-01, Vol.78 (2), p.73-76 |
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| creator | Lindeman, Jan H.N. Lentjes, Eef G.W.M. van Zoeren-Grobben, Diny Berger, Howard M. |
| description | Postnatal changes in plasma ceruloplasmin ferroxidase and transferrin iron-binding antioxidant activity were studied in 10 healthy preterm babies during the first 6 weeks of life. Ceruloplasmin levels and ceruloplasmin ferroxidase activity were low at birth, remained stable for the first 3 weeks, and increased between 3 and 6 weeks. The transferrin levels were also low at birth, and this finding persisted throughout the 6-week study period. However, although the plasma iron-binding antioxidant activity was correspondingly low at birth, it thereafter rose and remained high. In four cord blood samples, but not in subsequent postnatal samples, peroxidation was actually stimulated in the assay measuring plasma iron-binding antioxidant activity. We have previously shown that this phenomenon is probably due to the presence of non-protein-bound iron. |
| doi_str_mv | 10.1159/000014252 |
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Ceruloplasmin levels and ceruloplasmin ferroxidase activity were low at birth, remained stable for the first 3 weeks, and increased between 3 and 6 weeks. The transferrin levels were also low at birth, and this finding persisted throughout the 6-week study period. However, although the plasma iron-binding antioxidant activity was correspondingly low at birth, it thereafter rose and remained high. In four cord blood samples, but not in subsequent postnatal samples, peroxidation was actually stimulated in the assay measuring plasma iron-binding antioxidant activity. 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Ceruloplasmin levels and ceruloplasmin ferroxidase activity were low at birth, remained stable for the first 3 weeks, and increased between 3 and 6 weeks. The transferrin levels were also low at birth, and this finding persisted throughout the 6-week study period. However, although the plasma iron-binding antioxidant activity was correspondingly low at birth, it thereafter rose and remained high. In four cord blood samples, but not in subsequent postnatal samples, peroxidation was actually stimulated in the assay measuring plasma iron-binding antioxidant activity. We have previously shown that this phenomenon is probably due to the presence of non-protein-bound iron.</description><subject>Aging</subject><subject>Anesthesia. Intensive care medicine. Transfusions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antioxidants - analysis</topic><topic>Ascorbic Acid - chemistry</topic><topic>Biological and medical sciences</topic><topic>Ceruloplasmin - analysis</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - blood</topic><topic>Intensive care medicine</topic><topic>Iron - blood</topic><topic>Medical sciences</topic><topic>Original Paper</topic><topic>Oxidation-Reduction</topic><topic>Protein Binding</topic><topic>Transferrin - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindeman, Jan H.N.</creatorcontrib><creatorcontrib>Lentjes, Eef G.W.M.</creatorcontrib><creatorcontrib>van Zoeren-Grobben, Diny</creatorcontrib><creatorcontrib>Berger, Howard M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of the neonate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindeman, Jan H.N.</au><au>Lentjes, Eef G.W.M.</au><au>van Zoeren-Grobben, Diny</au><au>Berger, Howard M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postnatal Changes in Plasma Ceruloplasmin and Transferrin Antioxidant Activities in Preterm Babies</atitle><jtitle>Biology of the neonate</jtitle><addtitle>Neonatology</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>78</volume><issue>2</issue><spage>73</spage><epage>76</epage><pages>73-76</pages><issn>1661-7800</issn><issn>0006-3126</issn><eissn>1661-7819</eissn><eissn>1421-9727</eissn><coden>BNEOBV</coden><abstract>Postnatal changes in plasma ceruloplasmin ferroxidase and transferrin iron-binding antioxidant activity were studied in 10 healthy preterm babies during the first 6 weeks of life. Ceruloplasmin levels and ceruloplasmin ferroxidase activity were low at birth, remained stable for the first 3 weeks, and increased between 3 and 6 weeks. The transferrin levels were also low at birth, and this finding persisted throughout the 6-week study period. However, although the plasma iron-binding antioxidant activity was correspondingly low at birth, it thereafter rose and remained high. In four cord blood samples, but not in subsequent postnatal samples, peroxidation was actually stimulated in the assay measuring plasma iron-binding antioxidant activity. We have previously shown that this phenomenon is probably due to the presence of non-protein-bound iron.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10970997</pmid><doi>10.1159/000014252</doi><tpages>4</tpages></addata></record> |
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| subjects | Aging Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antioxidants - analysis Ascorbic Acid - chemistry Biological and medical sciences Ceruloplasmin - analysis Emergency and intensive care: neonates and children. Prematurity. Sudden death Humans Infant, Newborn Infant, Premature - blood Intensive care medicine Iron - blood Medical sciences Original Paper Oxidation-Reduction Protein Binding Transferrin - analysis |
| title | Postnatal Changes in Plasma Ceruloplasmin and Transferrin Antioxidant Activities in Preterm Babies |
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