Treating patients with movement disorders using MRI-guided focused ultrasound: recent developments and challenges
MRI-guided focused ultrasound (MRgFUS) is being considered in the treatment of movement disorders like essential tremor and Parkinson's disease and has shown promising preliminary results both in terms of effectiveness and safety. However, several technical challenges have come to light that mu...
Gespeichert in:
| Veröffentlicht in: | Research and Reports in Focused Ultrasound 2015-08, Vol.3, p.5 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 5 |
| container_title | Research and Reports in Focused Ultrasound |
| container_volume | 3 |
| creator | Tierney, Travis Field, Wesley Selvakumar, Tharakeswari Hayes, Michael |
| description | MRI-guided focused ultrasound (MRgFUS) is being considered in the treatment of movement disorders like essential tremor and Parkinson's disease and has shown promising preliminary results both in terms of effectiveness and safety. However, several technical challenges have come to light that must be addressed. This review examines several studies using MRgFUS to treat essential tremor and Parkinson's disease and discusses the following challenges: adequate energy delivery with brachycephalic and dense skulls, adverse events related to procedural time, the need to further understand the role of high-intensity focused ultrasound in brain mapping, and the need for multiple sonications at lesional temperatures for permanent tremor capture. Preliminary experiences reported with this technology have been promising, and the challenges discussed here can be addressed with additional data and experience. In the future, MRgFUS is likely to play an important role in the treatment of movement disorders. |
| doi_str_mv | 10.2147/RRFU.S63231 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2227456608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2227456608</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1011-9301debd88b20e3fe6605603fee0202482712e07f4ba39304ec38ea35af75ecd3</originalsourceid><addsrcrecordid>eNpNkF9LwzAUxYMoOOae_AIBH6Uzuelf32Q4HUyEuT2HrLndOtqmS9qJ395088Gncy78zrlwCLnnbAo8TJ5Wq_lm-hULEPyKjAAiEUDMsut__pZMnDswxiCDKBHZiBzXFlVXNjvaesGmc_S77Pa0Nies_Ul16YzVaB3t3YB9rBbBri81alqYvHde-6qzypm-0c_UYn5O4Qkr09bnQtVomu9VVWGzQ3dHbgpVOZz86Zhs5q_r2Xuw_HxbzF6WQc4Z50EmGNe41Wm6BYaiwDhmUcy8QQYMwhQSDsiSItwq4eEQc5GiEpEqkghzLcbk4dLbWnPs0XXyYHrb-JcSAJIw8oWppx4vVG6NcxYL2dqyVvZHciaHWeUwq7zMKn4Bg4tsFg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2227456608</pqid></control><display><type>article</type><title>Treating patients with movement disorders using MRI-guided focused ultrasound: recent developments and challenges</title><source>Dove Press Free</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Tierney, Travis ; Field, Wesley ; Selvakumar, Tharakeswari ; Hayes, Michael</creator><creatorcontrib>Tierney, Travis ; Field, Wesley ; Selvakumar, Tharakeswari ; Hayes, Michael</creatorcontrib><description>MRI-guided focused ultrasound (MRgFUS) is being considered in the treatment of movement disorders like essential tremor and Parkinson's disease and has shown promising preliminary results both in terms of effectiveness and safety. However, several technical challenges have come to light that must be addressed. This review examines several studies using MRgFUS to treat essential tremor and Parkinson's disease and discusses the following challenges: adequate energy delivery with brachycephalic and dense skulls, adverse events related to procedural time, the need to further understand the role of high-intensity focused ultrasound in brain mapping, and the need for multiple sonications at lesional temperatures for permanent tremor capture. Preliminary experiences reported with this technology have been promising, and the challenges discussed here can be addressed with additional data and experience. In the future, MRgFUS is likely to play an important role in the treatment of movement disorders.</description><identifier>ISSN: 2253-2609</identifier><identifier>EISSN: 2253-2609</identifier><identifier>DOI: 10.2147/RRFU.S63231</identifier><language>eng</language><publisher>Abingdon: Taylor & Francis Ltd</publisher><subject>Cavitation ; FDA approval ; Magnetic fields ; Neurology ; Neurosurgery ; NMR ; Nuclear magnetic resonance ; Parkinson's disease ; Patients ; Ratios ; Ultrasonic imaging</subject><ispartof>Research and Reports in Focused Ultrasound, 2015-08, Vol.3, p.5</ispartof><rights>2015. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3862,27924,27925</link.rule.ids></links><search><creatorcontrib>Tierney, Travis</creatorcontrib><creatorcontrib>Field, Wesley</creatorcontrib><creatorcontrib>Selvakumar, Tharakeswari</creatorcontrib><creatorcontrib>Hayes, Michael</creatorcontrib><title>Treating patients with movement disorders using MRI-guided focused ultrasound: recent developments and challenges</title><title>Research and Reports in Focused Ultrasound</title><description>MRI-guided focused ultrasound (MRgFUS) is being considered in the treatment of movement disorders like essential tremor and Parkinson's disease and has shown promising preliminary results both in terms of effectiveness and safety. However, several technical challenges have come to light that must be addressed. This review examines several studies using MRgFUS to treat essential tremor and Parkinson's disease and discusses the following challenges: adequate energy delivery with brachycephalic and dense skulls, adverse events related to procedural time, the need to further understand the role of high-intensity focused ultrasound in brain mapping, and the need for multiple sonications at lesional temperatures for permanent tremor capture. Preliminary experiences reported with this technology have been promising, and the challenges discussed here can be addressed with additional data and experience. In the future, MRgFUS is likely to play an important role in the treatment of movement disorders.</description><subject>Cavitation</subject><subject>FDA approval</subject><subject>Magnetic fields</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Ratios</subject><subject>Ultrasonic imaging</subject><issn>2253-2609</issn><issn>2253-2609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpNkF9LwzAUxYMoOOae_AIBH6Uzuelf32Q4HUyEuT2HrLndOtqmS9qJ395088Gncy78zrlwCLnnbAo8TJ5Wq_lm-hULEPyKjAAiEUDMsut__pZMnDswxiCDKBHZiBzXFlVXNjvaesGmc_S77Pa0Nies_Ul16YzVaB3t3YB9rBbBri81alqYvHde-6qzypm-0c_UYn5O4Qkr09bnQtVomu9VVWGzQ3dHbgpVOZz86Zhs5q_r2Xuw_HxbzF6WQc4Z50EmGNe41Wm6BYaiwDhmUcy8QQYMwhQSDsiSItwq4eEQc5GiEpEqkghzLcbk4dLbWnPs0XXyYHrb-JcSAJIw8oWppx4vVG6NcxYL2dqyVvZHciaHWeUwq7zMKn4Bg4tsFg</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Tierney, Travis</creator><creator>Field, Wesley</creator><creator>Selvakumar, Tharakeswari</creator><creator>Hayes, Michael</creator><general>Taylor & Francis Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201508</creationdate><title>Treating patients with movement disorders using MRI-guided focused ultrasound: recent developments and challenges</title><author>Tierney, Travis ; Field, Wesley ; Selvakumar, Tharakeswari ; Hayes, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1011-9301debd88b20e3fe6605603fee0202482712e07f4ba39304ec38ea35af75ecd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cavitation</topic><topic>FDA approval</topic><topic>Magnetic fields</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Ratios</topic><topic>Ultrasonic imaging</topic><toplevel>online_resources</toplevel><creatorcontrib>Tierney, Travis</creatorcontrib><creatorcontrib>Field, Wesley</creatorcontrib><creatorcontrib>Selvakumar, Tharakeswari</creatorcontrib><creatorcontrib>Hayes, Michael</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Research and Reports in Focused Ultrasound</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tierney, Travis</au><au>Field, Wesley</au><au>Selvakumar, Tharakeswari</au><au>Hayes, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treating patients with movement disorders using MRI-guided focused ultrasound: recent developments and challenges</atitle><jtitle>Research and Reports in Focused Ultrasound</jtitle><date>2015-08</date><risdate>2015</risdate><volume>3</volume><spage>5</spage><pages>5-</pages><issn>2253-2609</issn><eissn>2253-2609</eissn><abstract>MRI-guided focused ultrasound (MRgFUS) is being considered in the treatment of movement disorders like essential tremor and Parkinson's disease and has shown promising preliminary results both in terms of effectiveness and safety. However, several technical challenges have come to light that must be addressed. This review examines several studies using MRgFUS to treat essential tremor and Parkinson's disease and discusses the following challenges: adequate energy delivery with brachycephalic and dense skulls, adverse events related to procedural time, the need to further understand the role of high-intensity focused ultrasound in brain mapping, and the need for multiple sonications at lesional temperatures for permanent tremor capture. Preliminary experiences reported with this technology have been promising, and the challenges discussed here can be addressed with additional data and experience. In the future, MRgFUS is likely to play an important role in the treatment of movement disorders.</abstract><cop>Abingdon</cop><pub>Taylor & Francis Ltd</pub><doi>10.2147/RRFU.S63231</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2253-2609 |
| ispartof | Research and Reports in Focused Ultrasound, 2015-08, Vol.3, p.5 |
| issn | 2253-2609 2253-2609 |
| language | eng |
| recordid | cdi_proquest_journals_2227456608 |
| source | Dove Press Free; EZB-FREE-00999 freely available EZB journals |
| subjects | Cavitation FDA approval Magnetic fields Neurology Neurosurgery NMR Nuclear magnetic resonance Parkinson's disease Patients Ratios Ultrasonic imaging |
| title | Treating patients with movement disorders using MRI-guided focused ultrasound: recent developments and challenges |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T01%3A06%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Treating%20patients%20with%20movement%20disorders%20using%20MRI-guided%20focused%20ultrasound:%20recent%20developments%20and%20challenges&rft.jtitle=Research%20and%20Reports%20in%20Focused%20Ultrasound&rft.au=Tierney,%20Travis&rft.date=2015-08&rft.volume=3&rft.spage=5&rft.pages=5-&rft.issn=2253-2609&rft.eissn=2253-2609&rft_id=info:doi/10.2147/RRFU.S63231&rft_dat=%3Cproquest_cross%3E2227456608%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2227456608&rft_id=info:pmid/&rfr_iscdi=true |