CXCR4 acts as a costimulator during thymic [beta]-selection

Passage through the beta-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-beta gene (Tcrb) and formation of a pre-TCR on the surface of CD4(-)CD8(-) thymocytes. How other receptors influence betabeta-selection is less well understood. He...

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Veröffentlicht in:	Nature immunology 2010-02, Vol.11 (2), p.162
Hauptverfasser:	Trampont, Paul C, Tosello-trampont, Annie-carole, Shen, Yuelei, Duley, Amanda K, Sutherland, Ann E, Bender, Timothy P, Littman, Dan R, Ravichandran, Kodi S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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