Buprederm™, a New Transdermal Delivery System of Buprenorphine: Pharmacokinetic, Efficacy and Skin Irritancy Studies

Purpose The pharmacokinetics, analgesic efficacy, and irritancy potential of Buprederm™, a new transdermal delivery system of buprenorphine, was evaluated. Methods Single and multiple dose pharmacokinetic studies were conducted in mice and rabbits. The analgesic efficacy and skin irritation potentia...

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Veröffentlicht in:	Pharmaceutical research 2008-05, Vol.25 (5), p.1052-1062
Hauptverfasser:	Park, In, Kim, Dongwon, Song, Jindeog, In, Chang Hoon, Jeong, Seung-Wei, Lee, Sang Hun, Min, Bumchan, Lee, Dongho, Kim, Sun-Ok
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analgesics, Opioid - pharmacokinetics Animals Area Under Curve Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedical research Biomedicine Biotransformation Brain - metabolism Buprenorphine - administration & dosage Buprenorphine - adverse effects Buprenorphine - pharmacokinetics Dose-Response Relationship, Drug Drug Delivery Systems General pharmacology Irritants Medical Law Medical sciences Mice Pain management Pain Measurement - drug effects Pharmaceutical technology. Pharmaceutical industry Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Rabbits Reaction Time - drug effects Research Paper Rodents Skin Tests Transdermal medication
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