Effect of the Cytochrome P450 2C19 Inhibitor Omeprazole on the Pharmacokinetics and Safety Profile of Bortezomib in Patients with Advanced Solid Tumours, Non-Hodgkin’s Lymphoma or Multiple Myeloma

Background and objective: Bortezomib, an antineoplastic for the treatment of relapsed multiple myeloma and mantle cell lymphoma, undergoes metabolism through oxidative deboronation by cytochrome P450 (CYP) enzymes, primarily CYP3A4 and CYP2C19. Omeprazole, a proton-pump inhibitor, is primarily metab...

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Veröffentlicht in:	Clinical pharmacokinetics 2009-01, Vol.48 (3), p.199-209
Hauptverfasser:	Quinn, David I., Nemunaitis, John, Fuloria, Jyotsna, Britten, Carolyn D., Gabrail, Nashat, Yee, Lorrin, Acharya, Milin, Chan, Kai, Cohen, Nadine, Dudov, Assen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-Ulcer Agents - pharmacokinetics Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Area Under Curve Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Biological and medical sciences Boronic Acids - pharmacokinetics Boronic Acids - pharmacology Boronic Acids - therapeutic use Bortezomib Cancer Complications and side effects Cross-Over Studies Cytochrome P-450 CYP2C19 Dosage and administration Drug Administration Schedule Drug Interactions Drug therapy Female General pharmacology Hematologic and hematopoietic diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Internal Medicine Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - metabolism Male Medical sciences Medicine Medicine & Public Health Middle Aged Multiple Myeloma - drug therapy Multiple Myeloma - metabolism Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - drug therapy Neoplasms - metabolism Omeprazole Omeprazole - pharmacokinetics Omeprazole - pharmacology Omeprazole - therapeutic use Original Research Article Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacotherapy Proton Pump Inhibitors - pharmacokinetics Proton Pump Inhibitors - pharmacology Proton Pump Inhibitors - therapeutic use Pyrazines - pharmacokinetics Pyrazines - pharmacology Pyrazines - therapeutic use Tumors
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