Long circulating poly(ethylene glycol)-decorated lipid nanocapsules deliver docetaxel to solid tumors

The purpose of this study was to evaluate the ability of poly(ethylene glycol)-coated lipid nanocapsules (LN) to deliver the highly potent hydrophobic anticancer drug docetaxel to solid tumors. Docetaxel-loaded nanocapsules (80-120 nm) were produced by a solvent-free phase inversion process and were...

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Veröffentlicht in:	Pharmaceutical research 2006-04, Vol.23 (4), p.752-758
Hauptverfasser:	MOHAMED NABIL KHALID, SIMARD, Pierre, HOARAU, Didier, DRAGOMIR, Alice, LEROUX, Jean-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacokinetics Area Under Curve Biodistribution Biological and medical sciences Cancer Capsules Cell Line, Tumor Drug Carriers Drug Delivery Systems Drug stores Excipients Female General pharmacology Half-Life Humans Lipids Medical sciences Mice Mice, Inbred BALB C Nanoparticles Neoplasm Transplantation Neoplasms, Experimental - metabolism Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacokinetics Pharmacology. Drug treatments Pharmacy Polyethylene glycol Polyethylene Glycols Taxoids - administration & dosage Taxoids - pharmacokinetics Tissue Distribution Tumors
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