Induction of heme oxygenase-1 (HO-1) and NAD[P]H : Quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert -butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes

This study was aimed to investigate the effects of a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) on the induction of HO-1, NQO1 and Nrf2 proteins and their regulatory mechanisms in primary-cultured hepatocytes. After exposure of BHA and tBHQ...

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Veröffentlicht in:	Pharmaceutical research 2006-11, Vol.23 (11), p.2586-2594
Hauptverfasser:	KEUM, Young-Sam, HAN, Yong-Hae, LIEW, Celine, KIM, Jung-Hwan, CHANGJIANG XU, XIAOLING YUAN, SHAKARJIAN, Michael P, CHONG, Saeho, KONG, Ah-Ng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Biological and medical sciences Butylated Hydroxyanisole - pharmacology Cells, Cultured Dose-Response Relationship, Drug Enzyme Induction - drug effects Enzymes Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Enzymologic General pharmacology Heme Oxygenase-1 - biosynthesis Heme Oxygenase-1 - genetics Hepatocytes - enzymology Humans Hydroquinones - pharmacology JNK Mitogen-Activated Protein Kinases - metabolism Medical sciences Metabolism Mice Mice, Inbred C57BL NAD(P)H Dehydrogenase (Quinone) - biosynthesis NAD(P)H Dehydrogenase (Quinone) - genetics NF-E2-Related Factor 2 - physiology Oxygen Pharmaceutical technology. Pharmaceutical industry Pharmacology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Rodents
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