Metal Impurities in Food and Drugs
The major metals of potential health concern found in food, drugs (medicines), and dietary supplements are lead, cadmium, mercury, and arsenic. Other metals, such as chromium, copper, manganese, molybdenum, vanadium, nickel, osmium, rhodium, ruthenium, iridium, palladium, and platinum, may be used o...
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| Veröffentlicht in: | Pharmaceutical research 2010-05, Vol.27 (5), p.750-755 |
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| creator | Abernethy, Darrell R DeStefano, Anthony J Cecil, Todd L Zaidi, Kahkashan Williams, Roger L |
| description | The major metals of potential health concern found in food, drugs (medicines), and dietary supplements are lead, cadmium, mercury, and arsenic. Other metals, such as chromium, copper, manganese, molybdenum, vanadium, nickel, osmium, rhodium, ruthenium, iridium, palladium, and platinum, may be used or introduced during manufacturing and may be controlled in the final article as impurities. Screening for metals in medicines and dietary supplements rarely indicates the presence of toxic metal impurities at levels of concern. The setting of heavy metal limits is appropriate for medicines and is appropriate for supplements when heavy metals are likely or certain to contaminate a given product. Setting reasonable health-based limits for some of these metals is challenging because of their ubiquity in the environment, limitations of current analytical procedures, and other factors. Taken together, compendial tests for metals in food and drugs present an array of issues that challenge compendial scientists. |
| doi_str_mv | 10.1007/s11095-010-0080-3 |
| format | Article |
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Other metals, such as chromium, copper, manganese, molybdenum, vanadium, nickel, osmium, rhodium, ruthenium, iridium, palladium, and platinum, may be used or introduced during manufacturing and may be controlled in the final article as impurities. Screening for metals in medicines and dietary supplements rarely indicates the presence of toxic metal impurities at levels of concern. The setting of heavy metal limits is appropriate for medicines and is appropriate for supplements when heavy metals are likely or certain to contaminate a given product. Setting reasonable health-based limits for some of these metals is challenging because of their ubiquity in the environment, limitations of current analytical procedures, and other factors. Taken together, compendial tests for metals in food and drugs present an array of issues that challenge compendial scientists.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-010-0080-3</identifier><identifier>PMID: 20217462</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Animals ; Biochemistry ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Chemistry, Pharmaceutical ; Commentary ; Dietary supplements ; Drug Contamination ; Food Analysis ; Food contamination & poisoning ; Food Contamination - analysis ; General pharmacology ; Heavy metals ; Humans ; Medical Law ; Medical sciences ; Metals - analysis ; Metals - toxicity ; Pharmaceutical technology. Pharmaceutical industry ; Pharmaceuticals ; Pharmacology. 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Pharmaceutical industry</topic><topic>Pharmaceuticals</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacopoeias as Topic</topic><topic>Pharmacy</topic><topic>Public safety</topic><topic>Threshold Limit Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abernethy, Darrell R</creatorcontrib><creatorcontrib>DeStefano, Anthony J</creatorcontrib><creatorcontrib>Cecil, Todd L</creatorcontrib><creatorcontrib>Zaidi, Kahkashan</creatorcontrib><creatorcontrib>Williams, Roger L</creatorcontrib><creatorcontrib>USP Metal Impurities Advisory Panel</creatorcontrib><creatorcontrib>USP Metal Impurities Advisory Panel</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abernethy, Darrell R</au><au>DeStefano, Anthony J</au><au>Cecil, Todd L</au><au>Zaidi, Kahkashan</au><au>Williams, Roger L</au><aucorp>USP Metal Impurities Advisory Panel</aucorp><aucorp>USP Metal Impurities Advisory Panel</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metal Impurities in Food and Drugs</atitle><jtitle>Pharmaceutical research</jtitle><stitle>Pharm Res</stitle><addtitle>Pharm Res</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>27</volume><issue>5</issue><spage>750</spage><epage>755</epage><pages>750-755</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>The major metals of potential health concern found in food, drugs (medicines), and dietary supplements are lead, cadmium, mercury, and arsenic. 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| subjects | Animals Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Chemistry, Pharmaceutical Commentary Dietary supplements Drug Contamination Food Analysis Food contamination & poisoning Food Contamination - analysis General pharmacology Heavy metals Humans Medical Law Medical sciences Metals - analysis Metals - toxicity Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacopoeias as Topic Pharmacy Public safety Threshold Limit Values |
| title | Metal Impurities in Food and Drugs |
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