Psychotria leiocarpa Extract and Vincosamide Reduce Chemically-Induced Inflammation in Mice and Inhibit the Acetylcholinesterase Activity

Species from Psychotria are used in folk medicine against inflammatory diseases, respiratory disturbances, and anti-hallucinogenic. In the present study, the compound vincosamide (PL-1) was identified for the first time in methanolic extract of the Psychotria leiocarpa (ME-PL) leaves, as well as the...

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Veröffentlicht in:	Inflammation 2019-10, Vol.42 (5), p.1561-1574
Hauptverfasser:	Formagio, Anelise Samara Nazari, Volobuff, Carla Roberta Ferreira, Kassuya, Candida Aparecida Leite, Cardoso, Claudia Andréa Lima, do Carmo Vieira, Maria, Pereira, Zefa Valdevina, Bagatin, Mariane Cristovão, de Freitas Gauze, Gisele
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone Acetylcholinesterase Acetylcholinesterase - drug effects Animals Anti-inflammatory agents Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Biomedical and Life Sciences Biomedicine Chloroform Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Cortex (frontal) Edema Edema - drug therapy Hyperalgesia Hyperalgesia - drug therapy Immunology Indole Alkaloids - pharmacology Indole Alkaloids - therapeutic use Inflammation - chemically induced Inflammation - drug therapy Inflammatory diseases Internal Medicine Leukocyte migration Mice Molecular Docking Simulation Original Article Pain perception Pathology Pharmacology/Toxicology Phytotherapy - methods Plant Extracts - pharmacology Plant Extracts - therapeutic use Pleurisy Pleurisy - drug therapy Psychotria Psychotria - chemistry Rheumatology Toxicity
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