Why does PEG 400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres?

The aim of this work was to understand the mechanism by which co-encapsulated PEG 400 improved the stability of NGF and allowed a continuous release from PLGA 37.5/25 microspheres. Microparticles were prepared according to the double emulsion method. PEG 400 was added with NGF in the internal aqueou...

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Veröffentlicht in:	Pharmaceutical research 1999-08, Vol.16 (8), p.1294-1299
Hauptverfasser:	PEAN, J.-M, BOURY, F, VENIER-JULIENNE, M.-C, MENEI, P, PROUST, J.-E, BENOIT, J.-P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradation, Environmental Biological and medical sciences Capsules - metabolism Chloride Delayed-Action Preparations Drug Stability General pharmacology Growth factors Lactic Acid - chemistry Lactic Acid - metabolism Medical sciences Microspheres Nerve Growth Factor - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polyglycolic Acid - chemistry Polyglycolic Acid - metabolism Polylactic Acid-Polyglycolic Acid Copolymer Polymers Polymers - chemistry Polymers - metabolism Polyvinyl alcohol Proteins Scanning electron microscopy
Online-Zugang:	Volltext
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