Peroxisome Proliferator-Activated Receptor (PPAR)- : A Pharmacological Target with a Promising Future

Peroxisome proliferator-activated receptor (PPAR)-alpha is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPAR-alpha regulates the expression of genes involved in fatty acid beta-oxidation and is a major regulator of energy homeostasis. Fibrates are PPAR-a...

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Veröffentlicht in:	Pharmaceutical research 2004-09, Vol.21 (9), p.1531-1538
Hauptverfasser:	van Raalte, Daniel H., Li, Min, Pritchard, P. Haydn, Wasan, Kishor M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis Cardiovascular disease Cholesterol Dehydrogenases Diabetes Fatty acids High density lipoprotein Homeostasis Hormones Insulin resistance Ligands Low density lipoprotein Metabolic disorders Metabolic syndrome Nonsteroidal anti-inflammatory drugs Oxidation Pharmaceuticals Proteins Statins Tumor necrosis factor-TNF
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