Intra and Inter-Molecular Interactions Dictate the Aggregation State of Irinotecan Co-Encapsulated with Floxuridine Inside Liposomes

Purpose The inter/intramolecular interactions between drugs (floxuridine, irinotecan) and excipients (copper gluconate, triethanolamine) in the dual-drug liposomal formulation CPX-1 were elucidated in order to identify the physicochemical properties that allow coordinated release of irinotecan and f...

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Veröffentlicht in:	Pharmaceutical research 2008-07, Vol.25 (7), p.1702-1713
Hauptverfasser:	Dicko, Awa, Frazier, April A., Liboiron, Barry D., Hinderliter, Anne, Ellena, Jeff F., Xie, Xiaowei, Cho, Connie, Weber, Tom, Tardi, Paul G., Cabral-Lilly, Donna, Cafiso, David S., Mayer, Lawrence D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - chemistry Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Calorimetry Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - chemistry Chemical Phenomena Chemistry, Pharmaceutical Chemistry, Physical Cholesterol Copper Drug Carriers Drug Compounding Drugs Excipients Floxuridine - administration & dosage Floxuridine - chemistry General pharmacology Gluconates Liposomes Magnetic Resonance Spectroscopy Medical Law Medical sciences Microscopy, Electron, Transmission NMR Nuclear magnetic resonance Pharmaceutical technology. Pharmaceutical industry Pharmaceuticals Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Phosphatidylcholines Phosphatidylglycerols Plasma Ratios Research Paper Solubility Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Tumors
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