Drug marker absorption in relation to pellet size, gastric motility and viscous meals in humans

PURPOSE: The objective of this study was to evaluate drug marker absorption in relation to the gastric emptying (GE) of 0.7 mm and 3.6 mm enteric coated pellets as a function of viscosity and the underlying gastric motility. METHODS: Twelve subjects were evaluated in a 3-way crossover study. 0.7 mm...

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Veröffentlicht in:	Pharmaceutical research 1998-02, Vol.15 (2), p.233-238
Hauptverfasser:	Rhie, J. K., Hayashi, Y., Welage, L. S., Frens, J., Wald, R. J., Barnett, J. L., Amidon, G. E., Putcha, L., Amidon, G. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - pharmacokinetics Adult Analgesics Area Under Curve Biological and medical sciences Caffeine - pharmacokinetics Female Food-Drug Interactions Gastric Emptying Humans Life Sciences (General) Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Viscosity
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