Dexamethasone 21-Sulfate Improves the Therapeutic Properties of Dexamethasone Against Experimental Rat Colitis by Specifically Delivering the Steroid to the Large Intestine

Purpose We investigated in vivo-colon targetability and therapeutic properties of DS against experimental rat colitis. Methods The systemic absorption and colonic delivery of D after oral administration of DS was analyzed by examining the concentration of drugs in the GI tract, plasma, urine and fec...

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Veröffentlicht in:	Pharmaceutical research 2009-02, Vol.26 (2), p.415-421
Hauptverfasser:	Kim, Inho, Kong, Hyesik, Lee, Younghyun, Hong, Sungchae, Han, Jungoh, Jung, Sunhwa, Jung, Yunjin, Kim, Young Mi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenocorticotropic Hormone - blood Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacokinetics Anti-Inflammatory Agents - pharmacology Biochemistry Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Colitis - chemically induced Colitis - metabolism Colitis - pathology Colitis - prevention & control Colon Colon - drug effects Colon - metabolism Colon - pathology colon specific prodrug dexamethasone Dexamethasone - administration & dosage Dexamethasone - analogs & derivatives Dexamethasone - pharmacokinetics Dexamethasone - pharmacology dexamethasone 21-sulfate Disease Models, Animal Drug delivery systems Drug therapy Feces - chemistry Gastrointestinal Agents - administration & dosage Gastrointestinal Agents - pharmacokinetics Gastrointestinal Agents - pharmacology General pharmacology Hydrocortisone - blood Inflammatory bowel disease Intestinal Absorption Male Medical Law Medical sciences Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Prodrugs - administration & dosage Prodrugs - pharmacokinetics Prodrugs - pharmacology Rats Rats, Sprague-Dawley Research Paper Rodents Steroids Sulfates - administration & dosage Sulfates - pharmacokinetics Sulfates - pharmacology systemic adverse effect Trinitrobenzenesulfonic Acid
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