First‐in‐human phase I study of infusional and bolus schedules of Deflexifol, a novel 5‐fluorouracil and leucovorin formulation, after failure of standard treatment

Background 5‐Fluorouracil (5‐FU) is administered with leucovorin (LV) to enhance clinical activity. However, simultaneous administration is not feasible due to their chemical incompatibility, so conditions for the maximum possible beneficial interaction cannot be met. To overcome this, we developed...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Asia-Pacific journal of clinical oncology 2019-06, Vol.15 (3), p.151-157
Hauptverfasser:	Clingan, Philip R., Ackland, Stephen P., Brungs, Daniel, Souza, Paul, Aghmesheh, Morteza, Garg, Madhu B., Ranson, Richard D., Parker, Suzanne, Jokela, Rebecca, Ranson, Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil antimetabolites chemotherapy clinical trial colorectal cancer Diarrhea Disease control Malignancy Myelosuppression Patients Pharmacokinetics phase I β-Cyclodextrin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!