Dr. Sriramachari, founder neuropathologist of India

[1]{Figure 2}{Figure 3} Dr. Webb Haymaker was a strict disciplinarian who taught histo-morphology and pathology of the brain with military precision to the students and fellows who came from various parts of USA and the world. Besides working with Dr. Haymaker on experimental scorbutic brain in guinea pigs, Dr. Chari joined his group to study the effects of gravity on the developing monkey brain [Figure 4]. To overcome this deficiency, the biopsy tissue was frozen and the microtome knife cooled to -40° C with carbon-dioxide snow obtained by allowing the gas to escape into a gunny bag. Since the laboratory was far away from the operation theatre, even that procedure could not be followed for the peroperative biopsy processing. Free-hand sections of tissues were also cut by Maria Susai, using “quick-freeze spray” (containing ethyl chloride) to freeze the biopsy on a hand-held chuck and a barber's scalpel. [...]although there was no cryostat available at the OT, it did not prevent Dr. Chari from providing a rapid per-operative tentative diagnosis. [...]he had predicted in 1957 in that paper, the occurrence of non-atherosclerotic forms of vascular disease in oriental regions of the world.