Fatty acid transport protein 2 reprograms neutrophils in cancer

Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial for the regulation of immune responses in cancer. These cells contribute to the failure of cancer therapies and are associated with poor clinical outcomes. Despite recent advances...

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Veröffentlicht in:	Nature (London) 2019-05, Vol.569 (7754), p.73-78
Hauptverfasser:	Veglia, Filippo, Tyurin, Vladimir A., Blasi, Maria, De Leo, Alessandra, Kossenkov, Andrew V., Donthireddy, Laxminarasimha, To, Tsun Ki Jerrick, Schug, Zach, Basu, Subhasree, Wang, Fang, Ricciotti, Emanuela, DiRusso, Concetta, Murphy, Maureen E., Vonderheide, Robert H., Lieberman, Paul M., Mulligan, Charles, Nam, Brian, Hockstein, Neil, Masters, Gregory, Guarino, Michael, Lin, Cindy, Nefedova, Yulia, Black, Paul, Kagan, Valerian E., Gabrilovich, Dmitry I.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/31 13/44 42/41 45/91 631/250/580 631/67/327 64/60 Aged Animals Arachidonic acid Arachidonic Acid - metabolism Bone marrow Cancer Cancer treatment Cell activation Clonal deletion Colony-stimulating factor Dendritic cells Dinoprostone - metabolism Fatty Acid Transport Proteins - antagonists & inhibitors Fatty Acid Transport Proteins - metabolism Fatty acids Fatty Acids - metabolism Female Gene expression Genomes Granulocyte-macrophage colony stimulating factor Health aspects Humanities and Social Sciences Humans Immune checkpoint Immune response Immunosuppressive agents Leukocytes (neutrophilic) Lipid Metabolism Lipids Macrophage colony stimulating factor Macrophages Male Medical schools Mice Middle Aged multidisciplinary Neoplasms - metabolism Neoplasms - pathology Neutrophils Neutrophils - metabolism Neutrophils - pathology Pharmacology Physiological aspects Prostaglandin E2 Prostaglandins Protein transport Proteins Science Science (multidisciplinary) Stat5 protein STAT5 Transcription Factor - metabolism Suppressor cells Transcription activation Transport Transport proteins Triglycerides Tumors Unsaturated fatty acids
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