Relative Safety of Sexual Lubricants for Rectal Intercourse
Objective: The current study was conducted to determine the relative safety of sexual lubricants for rectal use. Goal: Our goal was to identify a sexual lubricant that would not damage the rectal epithelium. Study Design: We describe a mouse assay to determine the degree to which lubricants cause re...
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| Veröffentlicht in: | Sexually transmitted diseases 2004-06, Vol.31 (6), p.346-349 |
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| creator | SUDOL, KRISTIN M. PHILLIPS, DAVID M. |
| description | Objective: The current study was conducted to determine the relative safety of sexual lubricants for rectal use. Goal: Our goal was to identify a sexual lubricant that would not damage the rectal epithelium. Study Design: We describe a mouse assay to determine the degree to which lubricants cause rectal sloughing. We also tested lubricants for cytotoxicity and their effect on Herpes simplex virus (HSV-2) infection after rectal challenge. Results: Of the products tested, Delube and KY-Plus are most likely to damage the rectal epithelium, whereas Viamor, Vagisil, and Astroglide would cause some degree of rectal damage. PBS, Carraguard, and methylcellulose were not toxic in any of the assays. Conclusion: We have developed a quantitative method to assay the degree of sloughing of the rectal epithelium. Using this and other techniques, we are able to predict the degree to which lubricants could be safe for rectal use. |
| doi_str_mv | 10.1097/00007435-200406000-00005 |
| format | Article |
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Goal: Our goal was to identify a sexual lubricant that would not damage the rectal epithelium. Study Design: We describe a mouse assay to determine the degree to which lubricants cause rectal sloughing. We also tested lubricants for cytotoxicity and their effect on Herpes simplex virus (HSV-2) infection after rectal challenge. Results: Of the products tested, Delube and KY-Plus are most likely to damage the rectal epithelium, whereas Viamor, Vagisil, and Astroglide would cause some degree of rectal damage. PBS, Carraguard, and methylcellulose were not toxic in any of the assays. Conclusion: We have developed a quantitative method to assay the degree of sloughing of the rectal epithelium. Using this and other techniques, we are able to predict the degree to which lubricants could be safe for rectal use.</description><identifier>ISSN: 0148-5717</identifier><identifier>EISSN: 1537-4521</identifier><identifier>DOI: 10.1097/00007435-200406000-00005</identifier><identifier>PMID: 15167643</identifier><identifier>CODEN: STRDDM</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Epithelial Cells - drug effects ; Female ; General aspects ; Herpes viruses ; Herpesvirus 2, Human - drug effects ; Human infectious diseases. Experimental studies and models ; Infectious diseases ; Lubricants & lubrication ; Lubrication ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Microbial Sensitivity Tests ; Models, Animal ; Rectum - cytology ; Rectum - drug effects ; Sexual Behavior ; Sexually transmitted diseases ; STD</subject><ispartof>Sexually transmitted diseases, 2004-06, Vol.31 (6), p.346-349</ispartof><rights>Copyright © 2004 American Sexually Transmitted Diseases Association</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-bc399a61700bd114008a92285d116527b8bb4043f747eaf8aaa0f79aa1286e853</citedby><cites>FETCH-LOGICAL-c440t-bc399a61700bd114008a92285d116527b8bb4043f747eaf8aaa0f79aa1286e853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44966211$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44966211$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,30978,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15804127$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15167643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUDOL, KRISTIN M.</creatorcontrib><creatorcontrib>PHILLIPS, DAVID M.</creatorcontrib><title>Relative Safety of Sexual Lubricants for Rectal Intercourse</title><title>Sexually transmitted diseases</title><addtitle>Sex Transm Dis</addtitle><description>Objective: The current study was conducted to determine the relative safety of sexual lubricants for rectal use. Goal: Our goal was to identify a sexual lubricant that would not damage the rectal epithelium. Study Design: We describe a mouse assay to determine the degree to which lubricants cause rectal sloughing. We also tested lubricants for cytotoxicity and their effect on Herpes simplex virus (HSV-2) infection after rectal challenge. Results: Of the products tested, Delube and KY-Plus are most likely to damage the rectal epithelium, whereas Viamor, Vagisil, and Astroglide would cause some degree of rectal damage. PBS, Carraguard, and methylcellulose were not toxic in any of the assays. Conclusion: We have developed a quantitative method to assay the degree of sloughing of the rectal epithelium. Using this and other techniques, we are able to predict the degree to which lubricants could be safe for rectal use.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Epithelial Cells - drug effects</subject><subject>Female</subject><subject>General aspects</subject><subject>Herpes viruses</subject><subject>Herpesvirus 2, Human - drug effects</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Infectious diseases</subject><subject>Lubricants & lubrication</subject><subject>Lubrication</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbial Sensitivity Tests</subject><subject>Models, Animal</subject><subject>Rectum - cytology</subject><subject>Rectum - drug effects</subject><subject>Sexual Behavior</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><issn>0148-5717</issn><issn>1537-4521</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNpNkG9LwzAQxoMobk4_glIEX1bv0qRJ8ZUM_wwGwqavy7VLYGNrZ9KK-_amrk7vzfE8-d1deBiLEG4RMnUHoZRIZMwBBKRBxZ0lj9gQZaJiITkesyGg0LFUqAbszPsVdBrwlA1QYqpSkQzZ_cysqVl-mmhO1jS7qLbR3Hy1tI6mbeGWJVWNj2ztopkpm-BOqsa4sm6dN-fsxNLam4u-j9j70-Pb-CWevj5Pxg_TuBQCmrgokyyjFBVAsUAUAJoyzrUMIpVcFbooBIjEKqEMWU1EYFVGhFynRstkxK73e7eu_miNb_JVuF-FkznnXKQckw7Se6h0tffO2Hzrlhtyuxwh70LLf0PLD6H9WN3oVb-_LTZm8TfYpxSAmx4gX9LaOqrKpf_HaRDIVeAu99zKN7U7vAuRpeGTmHwDcBh7fQ</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>SUDOL, KRISTIN M.</creator><creator>PHILLIPS, DAVID M.</creator><general>Lippincott Williams & Wilkins</general><general>Lippincott</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7QL</scope><scope>7T2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>20040601</creationdate><title>Relative Safety of Sexual Lubricants for Rectal Intercourse</title><author>SUDOL, KRISTIN M. ; PHILLIPS, DAVID M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-bc399a61700bd114008a92285d116527b8bb4043f747eaf8aaa0f79aa1286e853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Epithelial Cells - drug effects</topic><topic>Female</topic><topic>General aspects</topic><topic>Herpes viruses</topic><topic>Herpesvirus 2, Human - drug effects</topic><topic>Human infectious diseases. Experimental studies and models</topic><topic>Infectious diseases</topic><topic>Lubricants & lubrication</topic><topic>Lubrication</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbial Sensitivity Tests</topic><topic>Models, Animal</topic><topic>Rectum - cytology</topic><topic>Rectum - drug effects</topic><topic>Sexual Behavior</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SUDOL, KRISTIN M.</creatorcontrib><creatorcontrib>PHILLIPS, DAVID M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Sexually transmitted diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUDOL, KRISTIN M.</au><au>PHILLIPS, DAVID M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative Safety of Sexual Lubricants for Rectal Intercourse</atitle><jtitle>Sexually transmitted diseases</jtitle><addtitle>Sex Transm Dis</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>31</volume><issue>6</issue><spage>346</spage><epage>349</epage><pages>346-349</pages><issn>0148-5717</issn><eissn>1537-4521</eissn><coden>STRDDM</coden><abstract>Objective: The current study was conducted to determine the relative safety of sexual lubricants for rectal use. Goal: Our goal was to identify a sexual lubricant that would not damage the rectal epithelium. Study Design: We describe a mouse assay to determine the degree to which lubricants cause rectal sloughing. We also tested lubricants for cytotoxicity and their effect on Herpes simplex virus (HSV-2) infection after rectal challenge. Results: Of the products tested, Delube and KY-Plus are most likely to damage the rectal epithelium, whereas Viamor, Vagisil, and Astroglide would cause some degree of rectal damage. PBS, Carraguard, and methylcellulose were not toxic in any of the assays. Conclusion: We have developed a quantitative method to assay the degree of sloughing of the rectal epithelium. Using this and other techniques, we are able to predict the degree to which lubricants could be safe for rectal use.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15167643</pmid><doi>10.1097/00007435-200406000-00005</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Sexually transmitted diseases, 2004-06, Vol.31 (6), p.346-349 |
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| source | MEDLINE; Journals@Ovid Complete; Applied Social Sciences Index & Abstracts (ASSIA); Jstor Complete Legacy |
| subjects | Animals Biological and medical sciences Epithelial Cells - drug effects Female General aspects Herpes viruses Herpesvirus 2, Human - drug effects Human infectious diseases. Experimental studies and models Infectious diseases Lubricants & lubrication Lubrication Medical sciences Mice Mice, Inbred BALB C Microbial Sensitivity Tests Models, Animal Rectum - cytology Rectum - drug effects Sexual Behavior Sexually transmitted diseases STD |
| title | Relative Safety of Sexual Lubricants for Rectal Intercourse |
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