Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity

Acute kidney injury (AKI) is associated with hypercoagulability. Tissue factor/factor VIIa complex and factor Xa in the coagulation cascade activate protease-activated receptor 2 (PAR2). Previously, we have shown that PAR2-mediated inflammation aggravates kidney injury in models of diabetic kidney d...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2019-04, Vol.316 (4), p.F654-F659
Hauptverfasser:	Watanabe, Mari, Oe, Yuji, Sato, Emiko, Sekimoto, Akiyo, Sato, Hiroshi, Ito, Sadayoshi, Takahashi, Nobuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Adenine Animals Antineoplastic Agents - toxicity Apoptosis Apoptosis - genetics Blood Urea Nitrogen Caspase Caspase-3 Chemokines Cisplatin Cisplatin - toxicity Coagulation factor VIIa Creatinine Creatinine - blood Cytokines Cytokines - metabolism Diabetes mellitus Fibrosis Gene expression Inflammation Kidney - pathology Kidney diseases Kidneys Leukocytes (neutrophilic) Male Mice Mice, Inbred C57BL Mice, Knockout Neutrophil Infiltration Receptor, PAR-2 - genetics Receptor, PAR-2 - metabolism Thromboplastin - metabolism Tissue factor Urea
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