Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats
This study was aimed at evaluating the ability of flibanserin, a 5-HT1A receptor full agonist with antidepressant potential, to induce the 5-HT syndrome (flat body posture, hindlimb abduction and forepaw treading) in rats previously administered with clinically active antidepressants imipramine, flu...
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| Veröffentlicht in: | The international journal of neuropsychopharmacology 2001-03, Vol.4 (1), p.9-15 |
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| creator | Borsini, Franco Brambilla, Alessandro Cesana, Raffaele Grippa, Nicoletta |
| description | This study was aimed at evaluating the ability of flibanserin, a 5-HT1A receptor full agonist with antidepressant potential, to induce the 5-HT syndrome (flat body posture, hindlimb abduction and forepaw treading) in rats previously administered with clinically active antidepressants imipramine, fluoxetine or paroxetine. The 5-HT syndrome was observed for 50 min after intraperitoneal administration of flibanserin (0, 8 or 64 mg/kg) given 10 min after antidepressants (0 or 15 mg/kg). Flibanserin induced flat body posture and very slight hindlimb abduction only at 64 mg/kg. No dose of flibanserin elicited forepaw treading. Similar but milder symptoms were induced by antidepressants. No interaction between flibanserin and antidepressants was observed. A dose of 10 mg/kg flibanserin did not change the flat body posture induced by 8 mg/kg (±)-8-OH-DPAT but antagonized (±)-8-OH-DPAT-induced forepaw treading. |
| doi_str_mv | 10.1017/S1461145701002206 |
| format | Article |
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The 5-HT syndrome was observed for 50 min after intraperitoneal administration of flibanserin (0, 8 or 64 mg/kg) given 10 min after antidepressants (0 or 15 mg/kg). Flibanserin induced flat body posture and very slight hindlimb abduction only at 64 mg/kg. No dose of flibanserin elicited forepaw treading. Similar but milder symptoms were induced by antidepressants. No interaction between flibanserin and antidepressants was observed. A dose of 10 mg/kg flibanserin did not change the flat body posture induced by 8 mg/kg (±)-8-OH-DPAT but antagonized (±)-8-OH-DPAT-induced forepaw treading.</description><identifier>ISSN: 1461-1457</identifier><identifier>EISSN: 1469-5111</identifier><identifier>DOI: 10.1017/S1461145701002206</identifier><identifier>PMID: 11343624</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology ; Animals ; Antidepressive Agents - pharmacology ; Antidepressive Agents, Second-Generation - pharmacology ; Antidepressive Agents, Tricyclic - pharmacology ; Benzimidazoles - pharmacology ; Drug Interactions - physiology ; Fluoxetine - pharmacology ; Imipramine - pharmacology ; Male ; Paroxetine - pharmacology ; Rats ; Rats, Sprague-Dawley ; Regular Research Article ; Serotonin Receptor Agonists - pharmacology ; Serotonin Syndrome - chemically induced</subject><ispartof>The international journal of neuropsychopharmacology, 2001-03, Vol.4 (1), p.9-15</ispartof><rights>2001 Collegium Internationale Neuropsychopharmacologicum</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-a3f2ae1de88c553e66fbe2fc0b36056ea9e20e1d18dc246813963a5fb9a3823c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11343624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borsini, Franco</creatorcontrib><creatorcontrib>Brambilla, Alessandro</creatorcontrib><creatorcontrib>Cesana, Raffaele</creatorcontrib><creatorcontrib>Grippa, Nicoletta</creatorcontrib><title>Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats</title><title>The international journal of neuropsychopharmacology</title><addtitle>Int. J. Neuropsychopharm</addtitle><description>This study was aimed at evaluating the ability of flibanserin, a 5-HT1A receptor full agonist with antidepressant potential, to induce the 5-HT syndrome (flat body posture, hindlimb abduction and forepaw treading) in rats previously administered with clinically active antidepressants imipramine, fluoxetine or paroxetine. The 5-HT syndrome was observed for 50 min after intraperitoneal administration of flibanserin (0, 8 or 64 mg/kg) given 10 min after antidepressants (0 or 15 mg/kg). Flibanserin induced flat body posture and very slight hindlimb abduction only at 64 mg/kg. No dose of flibanserin elicited forepaw treading. Similar but milder symptoms were induced by antidepressants. No interaction between flibanserin and antidepressants was observed. 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J. Neuropsychopharm</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>4</volume><issue>1</issue><spage>9</spage><epage>15</epage><pages>9-15</pages><issn>1461-1457</issn><eissn>1469-5111</eissn><abstract>This study was aimed at evaluating the ability of flibanserin, a 5-HT1A receptor full agonist with antidepressant potential, to induce the 5-HT syndrome (flat body posture, hindlimb abduction and forepaw treading) in rats previously administered with clinically active antidepressants imipramine, fluoxetine or paroxetine. The 5-HT syndrome was observed for 50 min after intraperitoneal administration of flibanserin (0, 8 or 64 mg/kg) given 10 min after antidepressants (0 or 15 mg/kg). Flibanserin induced flat body posture and very slight hindlimb abduction only at 64 mg/kg. No dose of flibanserin elicited forepaw treading. Similar but milder symptoms were induced by antidepressants. No interaction between flibanserin and antidepressants was observed. 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| subjects | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Antidepressive Agents - pharmacology Antidepressive Agents, Second-Generation - pharmacology Antidepressive Agents, Tricyclic - pharmacology Benzimidazoles - pharmacology Drug Interactions - physiology Fluoxetine - pharmacology Imipramine - pharmacology Male Paroxetine - pharmacology Rats Rats, Sprague-Dawley Regular Research Article Serotonin Receptor Agonists - pharmacology Serotonin Syndrome - chemically induced |
| title | Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats |
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