Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

By preventing G-actin accumulation, Rho-GTPase promotes the transcriptional activity of myocardin-related transcription factors (MRTFs), known co-factors of serum response factor (SRF). Rho-dependent MRTF expression is required for injected metastatic cell lines to colonize the lung. Rho GTPases con...

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Veröffentlicht in:	Nature cell biology 2009-03, Vol.11 (3), p.257-268
Hauptverfasser:	Medjkane, Souhila, Perez-Sanchez, Cristina, Gaggioli, Cedric, Sahai, Erik, Treisman, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adhesion Animals Biomedical and Life Sciences Breast cancer Cancer Research Cell adhesion & migration Cell Adhesion - drug effects Cell Biology Cell Line, Tumor Cell Movement - drug effects Colonization Cytochalasin B - pharmacology Cytoskeleton - drug effects Cytoskeleton - metabolism Developmental Biology DNA binding proteins Gene Expression Regulation, Neoplastic - drug effects Genes Genes, Reporter Guanosine triphosphatase Humans Kinases Laboratories Life Sciences Medical research Melanoma Metastasis Mice Motility Mutation - genetics Neoplasm Invasiveness Neoplasm Metastasis - pathology Physiological aspects Rats rho GTP-Binding Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Serum Response Factor - metabolism Signal Transduction - drug effects Stem Cells Transcription factors Transcription Factors - metabolism Tumors
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