Repeated effects of asenapine on adrenergic and cholinergic muscarinic receptors

Adrenergic (α1 and α2) and cholinergic muscarinic (M1–M5) receptor binding in rat forebrain was quantified after 4 wk of twice-daily subcutaneous administration of asenapine or vehicle. Asenapine (0.03, 0.1, and 0.3 mg/kg) produced increases in [3H]prazosin binding to α1-adrenergic receptors in the...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2010-04, Vol.13 (3), p.405-410
Hauptverfasser:	Choi, Yong Kee, Wong, Erik H. F., Henry, Brian, Shahid, Mohammed, Tarazi, Frank I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Agents - pharmacokinetics Animals Antipsychotic Agents - pharmacology Binding, Competitive - drug effects Cholinergic Agents - pharmacokinetics Dose-Response Relationship, Drug Drug Administration Schedule Heterocyclic Compounds, 4 or More Rings - pharmacology In Vitro Techniques Prosencephalon - drug effects Prosencephalon - metabolism Protein Binding - drug effects Radioligand Assay - methods Rats Receptors, Adrenergic - metabolism Receptors, Muscarinic - metabolism Tissue Distribution - drug effects Tritium - metabolism
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