Oral administration of graphene oxide nano-sheets induces oxidative stress, genotoxicity, and behavioral teratogenicity in Drosophila melanogaster
The current study checks the effect of various concentrations of dietary graphene oxide (GO) nano-sheets on the development of Drosophila melanogaster . GO was synthesized and characterized by XRD, FTIR, FESEM, and TEM analytical techniques. Various concentrations of GO were mixed with the fly food...
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| Veröffentlicht in: | Environmental science and pollution research international 2019-07, Vol.26 (19), p.19560-19574 |
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| creator | Priyadarsini, Subhashree Sahoo, Shraban Kumar Sahu, Swetapadma Mukherjee, Sumit Hota, Garudadhwaj Mishra, Monalisa |
| description | The current study checks the effect of various concentrations of dietary graphene oxide (GO) nano-sheets on the development of
Drosophila melanogaster
. GO was synthesized and characterized by XRD, FTIR, FESEM, and TEM analytical techniques. Various concentrations of GO were mixed with the fly food and flies were transferred to the vial. Various behavioral and morphological as well as genetic defects were checked on the different developmental stages of the offspring. In the larval stage of development, the crawling speed and trailing path change significantly than the control. GO induces the generation of oxygen radicals within the larval hemolymph as evidenced by nitroblue tetrazolium assay. GO induces DNA damage within the gut cell, which was detected by Hoechst staining and within hemolymph by comet assay. Adult flies hatched after GO treatment show defective phototaxis and geotaxis behavior. Besides behavior, phenotypic defects were observed in the wing, eye, thorax bristles, and mouth parts. At 300 mg/L concentration, wing spots were observed. Altogether, the current study finds oral administration of GO which acts as a mutagen and causes various behavioral and developmental defects in the offspring. Here for the first time, we are reporting GO, which acts as a teratogen in
Drosophila
, besides its extensive medical applications. |
| doi_str_mv | 10.1007/s11356-019-05357-x |
| format | Article |
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Drosophila melanogaster
. GO was synthesized and characterized by XRD, FTIR, FESEM, and TEM analytical techniques. Various concentrations of GO were mixed with the fly food and flies were transferred to the vial. Various behavioral and morphological as well as genetic defects were checked on the different developmental stages of the offspring. In the larval stage of development, the crawling speed and trailing path change significantly than the control. GO induces the generation of oxygen radicals within the larval hemolymph as evidenced by nitroblue tetrazolium assay. GO induces DNA damage within the gut cell, which was detected by Hoechst staining and within hemolymph by comet assay. Adult flies hatched after GO treatment show defective phototaxis and geotaxis behavior. Besides behavior, phenotypic defects were observed in the wing, eye, thorax bristles, and mouth parts. At 300 mg/L concentration, wing spots were observed. Altogether, the current study finds oral administration of GO which acts as a mutagen and causes various behavioral and developmental defects in the offspring. Here for the first time, we are reporting GO, which acts as a teratogen in
Drosophila
, besides its extensive medical applications.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-019-05357-x</identifier><identifier>PMID: 31079296</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Behavior ; Bioassays ; Bristles ; Comet assay ; Damage detection ; Defects ; Deoxyribonucleic acid ; Developmental stages ; DNA ; DNA damage ; Drosophila melanogaster ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Genotoxicity ; Geotaxis ; Graphene ; Hemolymph ; Insects ; Offspring ; Oral administration ; Oxidative stress ; Phototaxis ; Reactive oxygen species ; Research Article ; Sheets ; Teratogenicity ; Thorax ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2019-07, Vol.26 (19), p.19560-19574</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-54bf2dce60e2bbf7c2cc1679027d1edd042d778cdfd4f82fbc99f9211bee19963</citedby><cites>FETCH-LOGICAL-c412t-54bf2dce60e2bbf7c2cc1679027d1edd042d778cdfd4f82fbc99f9211bee19963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-019-05357-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-019-05357-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31079296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Priyadarsini, Subhashree</creatorcontrib><creatorcontrib>Sahoo, Shraban Kumar</creatorcontrib><creatorcontrib>Sahu, Swetapadma</creatorcontrib><creatorcontrib>Mukherjee, Sumit</creatorcontrib><creatorcontrib>Hota, Garudadhwaj</creatorcontrib><creatorcontrib>Mishra, Monalisa</creatorcontrib><title>Oral administration of graphene oxide nano-sheets induces oxidative stress, genotoxicity, and behavioral teratogenicity in Drosophila melanogaster</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>The current study checks the effect of various concentrations of dietary graphene oxide (GO) nano-sheets on the development of
Drosophila melanogaster
. GO was synthesized and characterized by XRD, FTIR, FESEM, and TEM analytical techniques. Various concentrations of GO were mixed with the fly food and flies were transferred to the vial. Various behavioral and morphological as well as genetic defects were checked on the different developmental stages of the offspring. In the larval stage of development, the crawling speed and trailing path change significantly than the control. GO induces the generation of oxygen radicals within the larval hemolymph as evidenced by nitroblue tetrazolium assay. GO induces DNA damage within the gut cell, which was detected by Hoechst staining and within hemolymph by comet assay. Adult flies hatched after GO treatment show defective phototaxis and geotaxis behavior. Besides behavior, phenotypic defects were observed in the wing, eye, thorax bristles, and mouth parts. At 300 mg/L concentration, wing spots were observed. Altogether, the current study finds oral administration of GO which acts as a mutagen and causes various behavioral and developmental defects in the offspring. Here for the first time, we are reporting GO, which acts as a teratogen in
Drosophila
, besides its extensive medical applications.</description><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Behavior</subject><subject>Bioassays</subject><subject>Bristles</subject><subject>Comet assay</subject><subject>Damage detection</subject><subject>Defects</subject><subject>Deoxyribonucleic acid</subject><subject>Developmental stages</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Drosophila melanogaster</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Genotoxicity</subject><subject>Geotaxis</subject><subject>Graphene</subject><subject>Hemolymph</subject><subject>Insects</subject><subject>Offspring</subject><subject>Oral administration</subject><subject>Oxidative stress</subject><subject>Phototaxis</subject><subject>Reactive oxygen species</subject><subject>Research Article</subject><subject>Sheets</subject><subject>Teratogenicity</subject><subject>Thorax</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution 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administration of graphene oxide nano-sheets induces oxidative stress, genotoxicity, and behavioral teratogenicity in Drosophila melanogaster</title><author>Priyadarsini, Subhashree ; Sahoo, Shraban Kumar ; Sahu, Swetapadma ; Mukherjee, Sumit ; Hota, Garudadhwaj ; Mishra, Monalisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-54bf2dce60e2bbf7c2cc1679027d1edd042d778cdfd4f82fbc99f9211bee19963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Behavior</topic><topic>Bioassays</topic><topic>Bristles</topic><topic>Comet assay</topic><topic>Damage detection</topic><topic>Defects</topic><topic>Deoxyribonucleic acid</topic><topic>Developmental stages</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Drosophila melanogaster</topic><topic>Earth and Environmental 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melanogaster</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>26</volume><issue>19</issue><spage>19560</spage><epage>19574</epage><pages>19560-19574</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>The current study checks the effect of various concentrations of dietary graphene oxide (GO) nano-sheets on the development of
Drosophila melanogaster
. GO was synthesized and characterized by XRD, FTIR, FESEM, and TEM analytical techniques. Various concentrations of GO were mixed with the fly food and flies were transferred to the vial. Various behavioral and morphological as well as genetic defects were checked on the different developmental stages of the offspring. In the larval stage of development, the crawling speed and trailing path change significantly than the control. GO induces the generation of oxygen radicals within the larval hemolymph as evidenced by nitroblue tetrazolium assay. GO induces DNA damage within the gut cell, which was detected by Hoechst staining and within hemolymph by comet assay. Adult flies hatched after GO treatment show defective phototaxis and geotaxis behavior. Besides behavior, phenotypic defects were observed in the wing, eye, thorax bristles, and mouth parts. At 300 mg/L concentration, wing spots were observed. Altogether, the current study finds oral administration of GO which acts as a mutagen and causes various behavioral and developmental defects in the offspring. Here for the first time, we are reporting GO, which acts as a teratogen in
Drosophila
, besides its extensive medical applications.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31079296</pmid><doi>10.1007/s11356-019-05357-x</doi><tpages>15</tpages></addata></record> |
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| ispartof | Environmental science and pollution research international, 2019-07, Vol.26 (19), p.19560-19574 |
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| subjects | Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Behavior Bioassays Bristles Comet assay Damage detection Defects Deoxyribonucleic acid Developmental stages DNA DNA damage Drosophila melanogaster Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Genotoxicity Geotaxis Graphene Hemolymph Insects Offspring Oral administration Oxidative stress Phototaxis Reactive oxygen species Research Article Sheets Teratogenicity Thorax Waste Water Technology Water Management Water Pollution Control |
| title | Oral administration of graphene oxide nano-sheets induces oxidative stress, genotoxicity, and behavioral teratogenicity in Drosophila melanogaster |
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