Regulation of cholesterol and sphingomyelin metabolism by amyloid-[beta] and presenilin

Amyloid beta peptide (Abeta) has a key role in the pathological process of Alzheimer's disease (AD), but the physiological function of Abeta and of the amyloid precursor protein (APP) is unknown. Recently, it was shown that APP processing is sensitive to cholesterol and other lipids. Hydroxymet...

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Veröffentlicht in:	Nature cell biology 2005-11, Vol.7 (11), p.1118
Hauptverfasser:	Grimm, Marcus O W, Grimm, Heike S, Pätzold, Andreas J, Zinser, Eva G, Halonen, Riikka, Duering, Marco, Jakob-A. Tschäpe, De Strooper, Bart, Müller, Ulrike, Shen, Jie, Hartmann, Tobias
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Biosynthesis Brain Cholesterol Disease Enzymes Homeostasis Lipids Metabolism Mutation Peptides Physiology Scientific imaging
Online-Zugang:	Volltext
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