Increases in lung expansion alter pulmonary hemodynamics in fetal sheep
1 Fetal and Neonatal Research Group, Department of Physiology, and 2 Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, Australia Submitted 13 December 2005 ; accepted in final form 18 March 2006 Prolonged increases in fetal lung expansion stimulate fetal lung g...
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| creator | Polglase, Graeme R Wallace, Megan J Morgan, David L Hooper, Stuart B |
| description | 1 Fetal and Neonatal Research Group, Department of Physiology, and 2 Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, Australia
Submitted 13 December 2005
; accepted in final form 18 March 2006
Prolonged increases in fetal lung expansion stimulate fetal lung growth and development, but the effects on pulmonary hemodynamics are unknown. Our aim was to determine the effect of increased fetal lung expansion, induced by tracheal obstruction (TO), on pulmonary blood flow (PBF) and vascular resistance (PVR). Chronically catheterized fetal sheep ( n = 6) underwent TO from 120 to 127 days of gestational age (term 147 days); tracheas were not obstructed in control fetuses ( n = 6). PBF, PVR, and changes to the PBF waveform were determined. TO significantly increased lung wet weight compared with control (166.3 ± 20.2 vs. 102.0 ± 18.8 g; P < 0.05). Despite the increase in intraluminal pressure caused by TO (5.0 ± 0.9 vs. 2.4 ± 1.0 mmHg; P < 0.001), PBF and PVR were similar between groups after 7 days (TO 28.1 ± 3.2 vs. control 34.1 ± 10.0 ml·min 1 ·100 g lung wt 1 ). However, TO markedly altered pulmonary hemodynamics associated with accentuated fetal breathing movements, causing a reduction rather than an increase in PBF at 7 days of TO. To account for the increase in intraluminal pressure, the pressure was equalized by draining the lungs of liquid on day 7 of TO. Pressure equalization increased PBF from 36.8 ± 5.2 to 112.4 ± 22.8 ml/min ( P = 0.01) and markedly altered the PBF waveform. These studies provide further evidence to indicate that intraluminal pressure is an important determinant of PBF and PVR in the fetus. We suggest that the increase in PBF associated with pressure equalization following TO reflects an increase in growth of the pulmonary vascular bed, leading to an increase in its cross-sectional area.
fetal breathing movements; Valsalva maneuvers; pulmonary blood flow
Address for reprint requests and other correspondence: G. Polglase, School of Womens and Infants Health (M094), Univ. of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia (e-mail: graeme.polglase{at}uwa.edu.au ) |
| doi_str_mv | 10.1152/japplphysiol.01544.2005 |
| format | Article |
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Submitted 13 December 2005
; accepted in final form 18 March 2006
Prolonged increases in fetal lung expansion stimulate fetal lung growth and development, but the effects on pulmonary hemodynamics are unknown. Our aim was to determine the effect of increased fetal lung expansion, induced by tracheal obstruction (TO), on pulmonary blood flow (PBF) and vascular resistance (PVR). Chronically catheterized fetal sheep ( n = 6) underwent TO from 120 to 127 days of gestational age (term 147 days); tracheas were not obstructed in control fetuses ( n = 6). PBF, PVR, and changes to the PBF waveform were determined. TO significantly increased lung wet weight compared with control (166.3 ± 20.2 vs. 102.0 ± 18.8 g; P < 0.05). Despite the increase in intraluminal pressure caused by TO (5.0 ± 0.9 vs. 2.4 ± 1.0 mmHg; P < 0.001), PBF and PVR were similar between groups after 7 days (TO 28.1 ± 3.2 vs. control 34.1 ± 10.0 ml·min 1 ·100 g lung wt 1 ). However, TO markedly altered pulmonary hemodynamics associated with accentuated fetal breathing movements, causing a reduction rather than an increase in PBF at 7 days of TO. To account for the increase in intraluminal pressure, the pressure was equalized by draining the lungs of liquid on day 7 of TO. Pressure equalization increased PBF from 36.8 ± 5.2 to 112.4 ± 22.8 ml/min ( P = 0.01) and markedly altered the PBF waveform. These studies provide further evidence to indicate that intraluminal pressure is an important determinant of PBF and PVR in the fetus. We suggest that the increase in PBF associated with pressure equalization following TO reflects an increase in growth of the pulmonary vascular bed, leading to an increase in its cross-sectional area.
fetal breathing movements; Valsalva maneuvers; pulmonary blood flow
Address for reprint requests and other correspondence: G. Polglase, School of Womens and Infants Health (M094), Univ. of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia (e-mail: graeme.polglase{at}uwa.edu.au )</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.01544.2005</identifier><identifier>PMID: 16575019</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Airway Obstruction - physiopathology ; Animals ; Biological and medical sciences ; Blood pressure ; Female ; Fetus - physiology ; Fundamental and applied biological sciences. Psychology ; Heart Rate - physiology ; Hemodynamics - physiology ; Lung - blood supply ; Lung - physiology ; Lungs ; Pregnancy ; Prenatal development ; Pulmonary Ventilation - physiology ; Regional Blood Flow - physiology ; Respiratory Mechanics - physiology ; Respiratory Physiological Phenomena ; Respiratory System - embryology ; Sheep ; Sheep - embryology ; Sheep - physiology ; Studies ; Vascular Resistance - physiology</subject><ispartof>Journal of applied physiology (1985), 2006-07, Vol.101 (1), p.273-282</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright American Physiological Society Jul 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-44449adb7e314d4992abad2c8db9b7692ef7d7752b14f2e037d0677aed9afe1f3</citedby><cites>FETCH-LOGICAL-c446t-44449adb7e314d4992abad2c8db9b7692ef7d7752b14f2e037d0677aed9afe1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17914709$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16575019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Polglase, Graeme R</creatorcontrib><creatorcontrib>Wallace, Megan J</creatorcontrib><creatorcontrib>Morgan, David L</creatorcontrib><creatorcontrib>Hooper, Stuart B</creatorcontrib><title>Increases in lung expansion alter pulmonary hemodynamics in fetal sheep</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Fetal and Neonatal Research Group, Department of Physiology, and 2 Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, Australia
Submitted 13 December 2005
; accepted in final form 18 March 2006
Prolonged increases in fetal lung expansion stimulate fetal lung growth and development, but the effects on pulmonary hemodynamics are unknown. Our aim was to determine the effect of increased fetal lung expansion, induced by tracheal obstruction (TO), on pulmonary blood flow (PBF) and vascular resistance (PVR). Chronically catheterized fetal sheep ( n = 6) underwent TO from 120 to 127 days of gestational age (term 147 days); tracheas were not obstructed in control fetuses ( n = 6). PBF, PVR, and changes to the PBF waveform were determined. TO significantly increased lung wet weight compared with control (166.3 ± 20.2 vs. 102.0 ± 18.8 g; P < 0.05). Despite the increase in intraluminal pressure caused by TO (5.0 ± 0.9 vs. 2.4 ± 1.0 mmHg; P < 0.001), PBF and PVR were similar between groups after 7 days (TO 28.1 ± 3.2 vs. control 34.1 ± 10.0 ml·min 1 ·100 g lung wt 1 ). However, TO markedly altered pulmonary hemodynamics associated with accentuated fetal breathing movements, causing a reduction rather than an increase in PBF at 7 days of TO. To account for the increase in intraluminal pressure, the pressure was equalized by draining the lungs of liquid on day 7 of TO. Pressure equalization increased PBF from 36.8 ± 5.2 to 112.4 ± 22.8 ml/min ( P = 0.01) and markedly altered the PBF waveform. These studies provide further evidence to indicate that intraluminal pressure is an important determinant of PBF and PVR in the fetus. We suggest that the increase in PBF associated with pressure equalization following TO reflects an increase in growth of the pulmonary vascular bed, leading to an increase in its cross-sectional area.
fetal breathing movements; Valsalva maneuvers; pulmonary blood flow
Address for reprint requests and other correspondence: G. Polglase, School of Womens and Infants Health (M094), Univ. of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia (e-mail: graeme.polglase{at}uwa.edu.au )</description><subject>Airway Obstruction - physiopathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Female</subject><subject>Fetus - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - physiology</subject><subject>Hemodynamics - physiology</subject><subject>Lung - blood supply</subject><subject>Lung - physiology</subject><subject>Lungs</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Regional Blood Flow - physiology</subject><subject>Respiratory Mechanics - physiology</subject><subject>Respiratory Physiological Phenomena</subject><subject>Respiratory System - embryology</subject><subject>Sheep</subject><subject>Sheep - embryology</subject><subject>Sheep - physiology</subject><subject>Studies</subject><subject>Vascular Resistance - physiology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFu1DAQhi0EokvhFSBCAnHJ4nGcOD6iipZKlbiUs-XEk01WjmPsRHTfHqcbUYTEXHyY7x_PfIS8A7oHKNnno_be-v4Uh8nuKZSc7xml5TOyS12WQ0XhOdnVoqS5KGtxQV7FeKQUOC_hJbmAqkwtkDtyc-vagDpizAaX2cUdMnzw2qXBLtN2xpD5xY6T0-GU9ThO5uT0OLSPeIeztlnsEf1r8qLTNuKb7b0kP66_3l99y---39xefbnLW86rOeeppDaNwAK44VIy3WjD2to0shGVZNgJI0TJGuAdQ1oIQyshNBqpO4SuuCQfz3N9mH4uGGc1DrFFa7XDaYmqqqkEKXkC3_8DHqcluLSbYufidYLEGWrDFGPATvkwjOlUBVStotXfotWjaLWKTsm32_ilGdE85TazCfiwATq22nZBu3aIT5yQwAVdOX7m-uHQ_xoCqu236XBS14u19_gwr2sABQWKiUJ5s3r49P9YotUfvPgNy1ur_w</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Polglase, Graeme R</creator><creator>Wallace, Megan J</creator><creator>Morgan, David L</creator><creator>Hooper, Stuart B</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>Increases in lung expansion alter pulmonary hemodynamics in fetal sheep</title><author>Polglase, Graeme R ; Wallace, Megan J ; Morgan, David L ; Hooper, Stuart B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-44449adb7e314d4992abad2c8db9b7692ef7d7752b14f2e037d0677aed9afe1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Airway Obstruction - physiopathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Female</topic><topic>Fetus - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - physiology</topic><topic>Hemodynamics - physiology</topic><topic>Lung - blood supply</topic><topic>Lung - physiology</topic><topic>Lungs</topic><topic>Pregnancy</topic><topic>Prenatal development</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Regional Blood Flow - physiology</topic><topic>Respiratory Mechanics - physiology</topic><topic>Respiratory Physiological Phenomena</topic><topic>Respiratory System - embryology</topic><topic>Sheep</topic><topic>Sheep - embryology</topic><topic>Sheep - physiology</topic><topic>Studies</topic><topic>Vascular Resistance - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Polglase, Graeme R</creatorcontrib><creatorcontrib>Wallace, Megan J</creatorcontrib><creatorcontrib>Morgan, David L</creatorcontrib><creatorcontrib>Hooper, Stuart B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Polglase, Graeme R</au><au>Wallace, Megan J</au><au>Morgan, David L</au><au>Hooper, Stuart B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increases in lung expansion alter pulmonary hemodynamics in fetal sheep</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>101</volume><issue>1</issue><spage>273</spage><epage>282</epage><pages>273-282</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Fetal and Neonatal Research Group, Department of Physiology, and 2 Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, Australia
Submitted 13 December 2005
; accepted in final form 18 March 2006
Prolonged increases in fetal lung expansion stimulate fetal lung growth and development, but the effects on pulmonary hemodynamics are unknown. Our aim was to determine the effect of increased fetal lung expansion, induced by tracheal obstruction (TO), on pulmonary blood flow (PBF) and vascular resistance (PVR). Chronically catheterized fetal sheep ( n = 6) underwent TO from 120 to 127 days of gestational age (term 147 days); tracheas were not obstructed in control fetuses ( n = 6). PBF, PVR, and changes to the PBF waveform were determined. TO significantly increased lung wet weight compared with control (166.3 ± 20.2 vs. 102.0 ± 18.8 g; P < 0.05). Despite the increase in intraluminal pressure caused by TO (5.0 ± 0.9 vs. 2.4 ± 1.0 mmHg; P < 0.001), PBF and PVR were similar between groups after 7 days (TO 28.1 ± 3.2 vs. control 34.1 ± 10.0 ml·min 1 ·100 g lung wt 1 ). However, TO markedly altered pulmonary hemodynamics associated with accentuated fetal breathing movements, causing a reduction rather than an increase in PBF at 7 days of TO. To account for the increase in intraluminal pressure, the pressure was equalized by draining the lungs of liquid on day 7 of TO. Pressure equalization increased PBF from 36.8 ± 5.2 to 112.4 ± 22.8 ml/min ( P = 0.01) and markedly altered the PBF waveform. These studies provide further evidence to indicate that intraluminal pressure is an important determinant of PBF and PVR in the fetus. We suggest that the increase in PBF associated with pressure equalization following TO reflects an increase in growth of the pulmonary vascular bed, leading to an increase in its cross-sectional area.
fetal breathing movements; Valsalva maneuvers; pulmonary blood flow
Address for reprint requests and other correspondence: G. Polglase, School of Womens and Infants Health (M094), Univ. of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia (e-mail: graeme.polglase{at}uwa.edu.au )</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>16575019</pmid><doi>10.1152/japplphysiol.01544.2005</doi><tpages>10</tpages></addata></record> |
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| subjects | Airway Obstruction - physiopathology Animals Biological and medical sciences Blood pressure Female Fetus - physiology Fundamental and applied biological sciences. Psychology Heart Rate - physiology Hemodynamics - physiology Lung - blood supply Lung - physiology Lungs Pregnancy Prenatal development Pulmonary Ventilation - physiology Regional Blood Flow - physiology Respiratory Mechanics - physiology Respiratory Physiological Phenomena Respiratory System - embryology Sheep Sheep - embryology Sheep - physiology Studies Vascular Resistance - physiology |
| title | Increases in lung expansion alter pulmonary hemodynamics in fetal sheep |
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