Effect of surface tension on alveolar surface area
1 Harvard Medical School, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's Hospital, 2 Physiology Program, Harvard School of Public Health, and 3 Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02115; and 4 Harvard College a...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2002-09, Vol.93 (3), p.1015-1022 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Butler, James P Brown, Richard E Stamenovic, Dimitrije Morris, John P Topulos, George P |
| description | 1 Harvard Medical School, Department of
Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's
Hospital, 2 Physiology Program, Harvard School of Public
Health, and 3 Department of Biomedical Engineering,
Boston University, Boston, Massachusetts 02115; and
4 Harvard College and 5 Harvard Extension
School, Cambridge, Massachusetts 02138
At fixed
lung volume (V L ), alterations in surface tension change
alveolar surface area (S) and lung recoil (P L ).
Wilson (26), using data from fixed lungs (1, 9), quantified the isovolume change in S with P L . We
reexamined this question in fresh excised rabbit lungs, with two
important differences. First, we measured fractional changes in S by
using diffuse light scattering, avoiding the potential upset of the
balance of tissue and surface forces during fixation. Second, we
altered surface tension by ventilating the lungs with nebulized
polydimethylsiloxane, with much less residual fluid compared with
lavage. We found that S decreased at low and mid V L
(treatment surface tension > control) by about half of Wilson's estimates and was nearly unaffected by treatment at high
V L . This suggests that with increased surface tension there
is 1 ) greater septal retraction in lungs fixed by vascular
perfusion compared with unfixed lungs and 2 ) a greater
increase in P L and less loss of S than would have been predicted.
lung; mechanics; lung recoil |
| doi_str_mv | 10.1152/japplphysiol.00126.2001 |
| format | Article |
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Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's
Hospital, 2 Physiology Program, Harvard School of Public
Health, and 3 Department of Biomedical Engineering,
Boston University, Boston, Massachusetts 02115; and
4 Harvard College and 5 Harvard Extension
School, Cambridge, Massachusetts 02138
At fixed
lung volume (V L ), alterations in surface tension change
alveolar surface area (S) and lung recoil (P L ).
Wilson (26), using data from fixed lungs (1, 9), quantified the isovolume change in S with P L . We
reexamined this question in fresh excised rabbit lungs, with two
important differences. First, we measured fractional changes in S by
using diffuse light scattering, avoiding the potential upset of the
balance of tissue and surface forces during fixation. Second, we
altered surface tension by ventilating the lungs with nebulized
polydimethylsiloxane, with much less residual fluid compared with
lavage. We found that S decreased at low and mid V L
(treatment surface tension > control) by about half of Wilson's estimates and was nearly unaffected by treatment at high
V L . This suggests that with increased surface tension there
is 1 ) greater septal retraction in lungs fixed by vascular
perfusion compared with unfixed lungs and 2 ) a greater
increase in P L and less loss of S than would have been predicted.
lung; mechanics; lung recoil</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00126.2001</identifier><identifier>PMID: 12183498</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Air breathing ; Animals ; Biological and medical sciences ; Dimethylpolysiloxanes - administration & dosage ; Dimethylpolysiloxanes - pharmacology ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Lung - drug effects ; Lung - physiology ; Lung Compliance ; Lung Volume Measurements ; Lungs ; Nebulizers and Vaporizers ; Pulmonary Alveoli - anatomy & histology ; Pulmonary Alveoli - drug effects ; Pulmonary Alveoli - physiology ; Rabbits ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Silicones - administration & dosage ; Silicones - pharmacology ; Surface Tension - drug effects ; Vertebrates: respiratory system ; Wetting Agents - administration & dosage ; Wetting Agents - pharmacology</subject><ispartof>Journal of applied physiology (1985), 2002-09, Vol.93 (3), p.1015-1022</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Physiological Society Sep 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-1b5af85c54f411dee438f50697d19bc5fc817cd0c51e1ff20c5771406e8e397e3</citedby><cites>FETCH-LOGICAL-c510t-1b5af85c54f411dee438f50697d19bc5fc817cd0c51e1ff20c5771406e8e397e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13864710$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12183498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butler, James P</creatorcontrib><creatorcontrib>Brown, Richard E</creatorcontrib><creatorcontrib>Stamenovic, Dimitrije</creatorcontrib><creatorcontrib>Morris, John P</creatorcontrib><creatorcontrib>Topulos, George P</creatorcontrib><creatorcontrib>With the Technical Assistance of Lydia S. Stickneyand Shasta Kielbasa</creatorcontrib><title>Effect of surface tension on alveolar surface area</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Harvard Medical School, Department of
Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's
Hospital, 2 Physiology Program, Harvard School of Public
Health, and 3 Department of Biomedical Engineering,
Boston University, Boston, Massachusetts 02115; and
4 Harvard College and 5 Harvard Extension
School, Cambridge, Massachusetts 02138
At fixed
lung volume (V L ), alterations in surface tension change
alveolar surface area (S) and lung recoil (P L ).
Wilson (26), using data from fixed lungs (1, 9), quantified the isovolume change in S with P L . We
reexamined this question in fresh excised rabbit lungs, with two
important differences. First, we measured fractional changes in S by
using diffuse light scattering, avoiding the potential upset of the
balance of tissue and surface forces during fixation. Second, we
altered surface tension by ventilating the lungs with nebulized
polydimethylsiloxane, with much less residual fluid compared with
lavage. We found that S decreased at low and mid V L
(treatment surface tension > control) by about half of Wilson's estimates and was nearly unaffected by treatment at high
V L . This suggests that with increased surface tension there
is 1 ) greater septal retraction in lungs fixed by vascular
perfusion compared with unfixed lungs and 2 ) a greater
increase in P L and less loss of S than would have been predicted.
lung; mechanics; lung recoil</description><subject>Air breathing</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dimethylpolysiloxanes - administration & dosage</subject><subject>Dimethylpolysiloxanes - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Lung - drug effects</subject><subject>Lung - physiology</subject><subject>Lung Compliance</subject><subject>Lung Volume Measurements</subject><subject>Lungs</subject><subject>Nebulizers and Vaporizers</subject><subject>Pulmonary Alveoli - anatomy & histology</subject><subject>Pulmonary Alveoli - drug effects</subject><subject>Pulmonary Alveoli - physiology</subject><subject>Rabbits</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Silicones - administration & dosage</subject><subject>Silicones - pharmacology</subject><subject>Surface Tension - drug effects</subject><subject>Vertebrates: respiratory system</subject><subject>Wetting Agents - administration & dosage</subject><subject>Wetting Agents - pharmacology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFr3DAQhUVpaDZp_0K7FBp68VYjS5Z8LCFpC4Fc0rPQyqOsF63tSnba_feZzZqkFCoEI5jvvRk9xj4AXwEo8WXrhiEOm31u-7jiHES1ElResQV1RQEVh9dsYbTihVZGn7KznLcESKngDTsFAaaUtVkwcRUC-nHZh2WeUnAelyN2ZNst6br4gH106bnnErq37CS4mPHdXM_Zz-uru8vvxc3ttx-XX28Kr4CPBayVC0Z5JYMEaBBlaYLiVa0bqNdeBW9A-4YTjRCCoIfWIHmFBstaY3nOLo6-Q-p_TZhHu2uzxxhdh_2UraYfm0rUBH78B9z2U-poNyvoQAWVJEgfIZ_6nBMGO6R259LeAreHTO3fmdqnTO0hU1K-n-2n9Q6bF90cIgGfZsBl72JIrvNtfuFKU0kNnLjPR27T3m9-twntPK2_3x-m27q0Ja0DilD5f_R6ivEO_4wHzbPEDk0oHwGkw6LE</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Butler, James P</creator><creator>Brown, Richard E</creator><creator>Stamenovic, Dimitrije</creator><creator>Morris, John P</creator><creator>Topulos, George P</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Effect of surface tension on alveolar surface area</title><author>Butler, James P ; Brown, Richard E ; Stamenovic, Dimitrije ; Morris, John P ; Topulos, George P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-1b5af85c54f411dee438f50697d19bc5fc817cd0c51e1ff20c5771406e8e397e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Air breathing</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dimethylpolysiloxanes - administration & dosage</topic><topic>Dimethylpolysiloxanes - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Lung - drug effects</topic><topic>Lung - physiology</topic><topic>Lung Compliance</topic><topic>Lung Volume Measurements</topic><topic>Lungs</topic><topic>Nebulizers and Vaporizers</topic><topic>Pulmonary Alveoli - anatomy & histology</topic><topic>Pulmonary Alveoli - drug effects</topic><topic>Pulmonary Alveoli - physiology</topic><topic>Rabbits</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Silicones - administration & dosage</topic><topic>Silicones - pharmacology</topic><topic>Surface Tension - drug effects</topic><topic>Vertebrates: respiratory system</topic><topic>Wetting Agents - administration & dosage</topic><topic>Wetting Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butler, James P</creatorcontrib><creatorcontrib>Brown, Richard E</creatorcontrib><creatorcontrib>Stamenovic, Dimitrije</creatorcontrib><creatorcontrib>Morris, John P</creatorcontrib><creatorcontrib>Topulos, George P</creatorcontrib><creatorcontrib>With the Technical Assistance of Lydia S. 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Stickneyand Shasta Kielbasa</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of surface tension on alveolar surface area</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>93</volume><issue>3</issue><spage>1015</spage><epage>1022</epage><pages>1015-1022</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Harvard Medical School, Department of
Anesthesiology, Perioperative and Pain Medicine, Brigham & Women's
Hospital, 2 Physiology Program, Harvard School of Public
Health, and 3 Department of Biomedical Engineering,
Boston University, Boston, Massachusetts 02115; and
4 Harvard College and 5 Harvard Extension
School, Cambridge, Massachusetts 02138
At fixed
lung volume (V L ), alterations in surface tension change
alveolar surface area (S) and lung recoil (P L ).
Wilson (26), using data from fixed lungs (1, 9), quantified the isovolume change in S with P L . We
reexamined this question in fresh excised rabbit lungs, with two
important differences. First, we measured fractional changes in S by
using diffuse light scattering, avoiding the potential upset of the
balance of tissue and surface forces during fixation. Second, we
altered surface tension by ventilating the lungs with nebulized
polydimethylsiloxane, with much less residual fluid compared with
lavage. We found that S decreased at low and mid V L
(treatment surface tension > control) by about half of Wilson's estimates and was nearly unaffected by treatment at high
V L . This suggests that with increased surface tension there
is 1 ) greater septal retraction in lungs fixed by vascular
perfusion compared with unfixed lungs and 2 ) a greater
increase in P L and less loss of S than would have been predicted.
lung; mechanics; lung recoil</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>12183498</pmid><doi>10.1152/japplphysiol.00126.2001</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2002-09, Vol.93 (3), p.1015-1022 |
| issn | 8750-7587 1522-1601 |
| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Air breathing Animals Biological and medical sciences Dimethylpolysiloxanes - administration & dosage Dimethylpolysiloxanes - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques Lung - drug effects Lung - physiology Lung Compliance Lung Volume Measurements Lungs Nebulizers and Vaporizers Pulmonary Alveoli - anatomy & histology Pulmonary Alveoli - drug effects Pulmonary Alveoli - physiology Rabbits Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Silicones - administration & dosage Silicones - pharmacology Surface Tension - drug effects Vertebrates: respiratory system Wetting Agents - administration & dosage Wetting Agents - pharmacology |
| title | Effect of surface tension on alveolar surface area |
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