Aging of skeletal muscle: a 12-yr longitudinal study
1 Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston 02114; 2 Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Medford...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2000-04, Vol.88 (4), p.1321-1326 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Frontera, Walter R Hughes, Virginia A Fielding, Roger A Fiatarone, Maria A Evans, William J Roubenoff, Ronenn |
| description | 1 Department of Physical Medicine and
Rehabilitation, Harvard Medical School and Spaulding Rehabilitation
Hospital, Boston 02114; 2 Nutrition, Exercise
Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of
Agriculture Human Nutrition Research Center on Aging, Tufts
University, Medford 02155; 3 Department of
Health Sciences, Sargent College of Health and Rehabilitation Sciences,
Boston University, Boston, Massachusetts 02215;
4 School of Exercise and Sport Science,
University of Sydney, Sydney, New South Wales 2006, Australia; and
5 Donald W. Reynolds Department of Geriatrics,
University of Arkansas for Medical Sciences, Little Rock, Arkansas
72204
The
present study examines age-related changes in skeletal muscle size and
function after 12 yr. Twelve healthy sedentary men were
studied in 1985-86 (T1) and nine (initial mean age 65.4 ± 4.2 yr) were reevaluated in 1997-98 (T2). Isokinetic
muscle strength of the knee and elbow extensors and flexors showed
losses ( P |
| doi_str_mv | 10.1152/jappl.2000.88.4.1321 |
| format | Article |
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Rehabilitation, Harvard Medical School and Spaulding Rehabilitation
Hospital, Boston 02114; 2 Nutrition, Exercise
Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of
Agriculture Human Nutrition Research Center on Aging, Tufts
University, Medford 02155; 3 Department of
Health Sciences, Sargent College of Health and Rehabilitation Sciences,
Boston University, Boston, Massachusetts 02215;
4 School of Exercise and Sport Science,
University of Sydney, Sydney, New South Wales 2006, Australia; and
5 Donald W. Reynolds Department of Geriatrics,
University of Arkansas for Medical Sciences, Little Rock, Arkansas
72204
The
present study examines age-related changes in skeletal muscle size and
function after 12 yr. Twelve healthy sedentary men were
studied in 1985-86 (T1) and nine (initial mean age 65.4 ± 4.2 yr) were reevaluated in 1997-98 (T2). Isokinetic
muscle strength of the knee and elbow extensors and flexors showed
losses ( P < 0.05) ranging from 20 to 30% at slow and fast
angular velocities. Computerized tomography ( n = 7) showed
reductions ( P < 0.05) in the cross-sectional area (CSA) of
the thigh (12.5%), all thigh muscles (14.7%), quadriceps femoris
muscle (16.1%), and flexor muscles (14.9%). Analysis of covariance
showed that strength at T1 and changes in CSA were independent
predictors of strength at T2. Muscle biopsies taken from vastus
lateralis muscles ( n = 6) showed a reduction in percentage of
type I fibers (T1 = 60% vs. T2 = 42%) with no change in mean area in
either fiber type. The capillary-to-fiber ratio was significantly lower
at T2 (1.39 vs. 1.08; P = 0.043). Our observations suggest that
a quantitative loss in muscle CSA is a major contributor to the
decrease in muscle strength seen with advancing age and, together with
muscle strength at T1, accounts for 90% of the variability in strength
at T2.
sarcopenia; muscle strength; muscle size; muscle fiber type and
area</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2000.88.4.1321</identifier><identifier>PMID: 10749826</identifier><language>eng</language><publisher>United States: Am Physiological Soc</publisher><subject>Aged ; Aging ; Aging - physiology ; Anatomy & physiology ; Capillaries - growth & development ; Capillaries - physiology ; Elbow Joint - physiology ; Humans ; Isometric Contraction ; Knee Joint - physiology ; Longitudinal Studies ; Male ; Middle Aged ; Muscle Development ; Muscle Fibers, Skeletal - cytology ; Muscle Fibers, Skeletal - physiology ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - growth & development ; Muscle, Skeletal - physiology ; Muscular system ; Time Factors ; Tomography, X-Ray Computed</subject><ispartof>Journal of applied physiology (1985), 2000-04, Vol.88 (4), p.1321-1326</ispartof><rights>Copyright American Physiological Society Apr 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-6c1ed58ae6a477ab7df2d2629c7735b64a9d781c4d51c44b37d8ad6cb85ec13e3</citedby><cites>FETCH-LOGICAL-c520t-6c1ed58ae6a477ab7df2d2629c7735b64a9d781c4d51c44b37d8ad6cb85ec13e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10749826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frontera, Walter R</creatorcontrib><creatorcontrib>Hughes, Virginia A</creatorcontrib><creatorcontrib>Fielding, Roger A</creatorcontrib><creatorcontrib>Fiatarone, Maria A</creatorcontrib><creatorcontrib>Evans, William J</creatorcontrib><creatorcontrib>Roubenoff, Ronenn</creatorcontrib><title>Aging of skeletal muscle: a 12-yr longitudinal study</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Department of Physical Medicine and
Rehabilitation, Harvard Medical School and Spaulding Rehabilitation
Hospital, Boston 02114; 2 Nutrition, Exercise
Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of
Agriculture Human Nutrition Research Center on Aging, Tufts
University, Medford 02155; 3 Department of
Health Sciences, Sargent College of Health and Rehabilitation Sciences,
Boston University, Boston, Massachusetts 02215;
4 School of Exercise and Sport Science,
University of Sydney, Sydney, New South Wales 2006, Australia; and
5 Donald W. Reynolds Department of Geriatrics,
University of Arkansas for Medical Sciences, Little Rock, Arkansas
72204
The
present study examines age-related changes in skeletal muscle size and
function after 12 yr. Twelve healthy sedentary men were
studied in 1985-86 (T1) and nine (initial mean age 65.4 ± 4.2 yr) were reevaluated in 1997-98 (T2). Isokinetic
muscle strength of the knee and elbow extensors and flexors showed
losses ( P < 0.05) ranging from 20 to 30% at slow and fast
angular velocities. Computerized tomography ( n = 7) showed
reductions ( P < 0.05) in the cross-sectional area (CSA) of
the thigh (12.5%), all thigh muscles (14.7%), quadriceps femoris
muscle (16.1%), and flexor muscles (14.9%). Analysis of covariance
showed that strength at T1 and changes in CSA were independent
predictors of strength at T2. Muscle biopsies taken from vastus
lateralis muscles ( n = 6) showed a reduction in percentage of
type I fibers (T1 = 60% vs. T2 = 42%) with no change in mean area in
either fiber type. The capillary-to-fiber ratio was significantly lower
at T2 (1.39 vs. 1.08; P = 0.043). Our observations suggest that
a quantitative loss in muscle CSA is a major contributor to the
decrease in muscle strength seen with advancing age and, together with
muscle strength at T1, accounts for 90% of the variability in strength
at T2.
sarcopenia; muscle strength; muscle size; muscle fiber type and
area</description><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Anatomy & physiology</subject><subject>Capillaries - growth & development</subject><subject>Capillaries - physiology</subject><subject>Elbow Joint - physiology</subject><subject>Humans</subject><subject>Isometric Contraction</subject><subject>Knee Joint - physiology</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Development</subject><subject>Muscle Fibers, Skeletal - cytology</subject><subject>Muscle Fibers, Skeletal - physiology</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscular system</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAYRYMoOj7-gUhxIW5a86VJk3E3iC8YcKPrkCZpp2NmWpsW7b83dQZRwSySwHfuJTkInQJOABi5WqqmcQnBGCdCJDSBlMAOmoQRiSHDsIsmgjMccyb4ATr0fokxUMpgHx0A5nQqSDZBdFZW6zKqi8i_Wmc75aJV77Wz15GKgMRDG7l6XVZdb6p1GPpwGY7RXqGctyfb8wi93N0-3zzE86f7x5vZPNaM4C7ONFjDhLKZopyrnJuCGJKRqeY8ZXlG1dRwAZoaFjaap9wIZTKdC2Y1pDY9Qheb3qat33rrO7mqvLbOqbWtey85hC9hngXw_A-4rPs2vNdLEhYQjiFAdAPptva-tYVs2mql2kEClqNS-aVUjkqlEJLKUWmInW27-3xlzY_QxmEALjfAoioX71VrZbMYfFW7uhzGyl9d9H_0rnfu2X50Y-Y7IhtTpJ_-vpKz</recordid><startdate>20000401</startdate><enddate>20000401</enddate><creator>Frontera, Walter R</creator><creator>Hughes, Virginia A</creator><creator>Fielding, Roger A</creator><creator>Fiatarone, Maria A</creator><creator>Evans, William J</creator><creator>Roubenoff, Ronenn</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20000401</creationdate><title>Aging of skeletal muscle: a 12-yr longitudinal study</title><author>Frontera, Walter R ; Hughes, Virginia A ; Fielding, Roger A ; Fiatarone, Maria A ; Evans, William J ; Roubenoff, Ronenn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-6c1ed58ae6a477ab7df2d2629c7735b64a9d781c4d51c44b37d8ad6cb85ec13e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Anatomy & physiology</topic><topic>Capillaries - growth & development</topic><topic>Capillaries - physiology</topic><topic>Elbow Joint - physiology</topic><topic>Humans</topic><topic>Isometric Contraction</topic><topic>Knee Joint - physiology</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Development</topic><topic>Muscle Fibers, Skeletal - cytology</topic><topic>Muscle Fibers, Skeletal - physiology</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Muscle, Skeletal - physiology</topic><topic>Muscular system</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frontera, Walter R</creatorcontrib><creatorcontrib>Hughes, Virginia A</creatorcontrib><creatorcontrib>Fielding, Roger A</creatorcontrib><creatorcontrib>Fiatarone, Maria A</creatorcontrib><creatorcontrib>Evans, William J</creatorcontrib><creatorcontrib>Roubenoff, Ronenn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frontera, Walter R</au><au>Hughes, Virginia A</au><au>Fielding, Roger A</au><au>Fiatarone, Maria A</au><au>Evans, William J</au><au>Roubenoff, Ronenn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging of skeletal muscle: a 12-yr longitudinal study</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2000-04-01</date><risdate>2000</risdate><volume>88</volume><issue>4</issue><spage>1321</spage><epage>1326</epage><pages>1321-1326</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><abstract>1 Department of Physical Medicine and
Rehabilitation, Harvard Medical School and Spaulding Rehabilitation
Hospital, Boston 02114; 2 Nutrition, Exercise
Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of
Agriculture Human Nutrition Research Center on Aging, Tufts
University, Medford 02155; 3 Department of
Health Sciences, Sargent College of Health and Rehabilitation Sciences,
Boston University, Boston, Massachusetts 02215;
4 School of Exercise and Sport Science,
University of Sydney, Sydney, New South Wales 2006, Australia; and
5 Donald W. Reynolds Department of Geriatrics,
University of Arkansas for Medical Sciences, Little Rock, Arkansas
72204
The
present study examines age-related changes in skeletal muscle size and
function after 12 yr. Twelve healthy sedentary men were
studied in 1985-86 (T1) and nine (initial mean age 65.4 ± 4.2 yr) were reevaluated in 1997-98 (T2). Isokinetic
muscle strength of the knee and elbow extensors and flexors showed
losses ( P < 0.05) ranging from 20 to 30% at slow and fast
angular velocities. Computerized tomography ( n = 7) showed
reductions ( P < 0.05) in the cross-sectional area (CSA) of
the thigh (12.5%), all thigh muscles (14.7%), quadriceps femoris
muscle (16.1%), and flexor muscles (14.9%). Analysis of covariance
showed that strength at T1 and changes in CSA were independent
predictors of strength at T2. Muscle biopsies taken from vastus
lateralis muscles ( n = 6) showed a reduction in percentage of
type I fibers (T1 = 60% vs. T2 = 42%) with no change in mean area in
either fiber type. The capillary-to-fiber ratio was significantly lower
at T2 (1.39 vs. 1.08; P = 0.043). Our observations suggest that
a quantitative loss in muscle CSA is a major contributor to the
decrease in muscle strength seen with advancing age and, together with
muscle strength at T1, accounts for 90% of the variability in strength
at T2.
sarcopenia; muscle strength; muscle size; muscle fiber type and
area</abstract><cop>United States</cop><pub>Am Physiological Soc</pub><pmid>10749826</pmid><doi>10.1152/jappl.2000.88.4.1321</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2000-04, Vol.88 (4), p.1321-1326 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_proquest_journals_222212701 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aged Aging Aging - physiology Anatomy & physiology Capillaries - growth & development Capillaries - physiology Elbow Joint - physiology Humans Isometric Contraction Knee Joint - physiology Longitudinal Studies Male Middle Aged Muscle Development Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - physiology Muscle, Skeletal - blood supply Muscle, Skeletal - growth & development Muscle, Skeletal - physiology Muscular system Time Factors Tomography, X-Ray Computed |
| title | Aging of skeletal muscle: a 12-yr longitudinal study |
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