Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species

1 Abramson Family Cancer Research Institute and 2 Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Submitted 27 April 2004 ; accepted in final form 27 May 2004 When exposed to hypoxia (1.5% O 2 ), several cell types have been shown to increase production...

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