Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments
Department of Physiology, University of Western Australia, Nedlands, Western Australia 6009, Australia Structural components of the airway wall may act to load airway smooth muscle and restrict airway narrowing. In this study, the effect of load on airway narrowing was investigated in pig isolated b...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2002-03, Vol.92 (3), p.1119-1124 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Noble, P. B Turner, D. J Mitchell, H. W |
| description | Department of Physiology, University of Western
Australia, Nedlands, Western Australia 6009, Australia
Structural components of the
airway wall may act to load airway smooth muscle and restrict airway
narrowing. In this study, the effect of load on airway narrowing was
investigated in pig isolated bronchial segments. In some bronchi,
pieces of cartilage were removed by careful dissection. Airway
narrowing was produced by maximum electrical field stimulation. An
endoscope was used to record lumen narrowing. The compliance of the
bronchial segments was determined from the cross-sectional area of the
lumen and the transmural pressure. Airway narrowing and the velocity of airway narrowing were increased in cartilage-removed airways compared with intact control bronchi. Morphometric assessment of smooth muscle
length showed greater muscle shortening to acetylcholine in
cartilage-removed airways than in controls. Airway narrowing was
positively correlated with airway compliance. Compliance and area of
cartilage were negatively correlated. These results show that airway
narrowing is increased in compliant airways and that cartilage
significantly loads airway smooth muscle in whole bronchi.
airway smooth muscle; asthma |
| doi_str_mv | 10.1152/japplphysiol.00662.2001 |
| format | Article |
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Australia, Nedlands, Western Australia 6009, Australia
Structural components of the
airway wall may act to load airway smooth muscle and restrict airway
narrowing. In this study, the effect of load on airway narrowing was
investigated in pig isolated bronchial segments. In some bronchi,
pieces of cartilage were removed by careful dissection. Airway
narrowing was produced by maximum electrical field stimulation. An
endoscope was used to record lumen narrowing. The compliance of the
bronchial segments was determined from the cross-sectional area of the
lumen and the transmural pressure. Airway narrowing and the velocity of airway narrowing were increased in cartilage-removed airways compared with intact control bronchi. Morphometric assessment of smooth muscle
length showed greater muscle shortening to acetylcholine in
cartilage-removed airways than in controls. Airway narrowing was
positively correlated with airway compliance. Compliance and area of
cartilage were negatively correlated. These results show that airway
narrowing is increased in compliant airways and that cartilage
significantly loads airway smooth muscle in whole bronchi.
airway smooth muscle; asthma</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.00662.2001</identifier><identifier>PMID: 11842048</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Acetylcholine - pharmacology ; Air breathing ; Animals ; Asthma ; Biological and medical sciences ; Bronchi - drug effects ; Bronchi - physiology ; Bronchoconstriction - physiology ; Bronchoscopy ; Cartilage - physiology ; Electric Stimulation ; Female ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Lung Compliance ; Muscle Contraction ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Pressure ; Respiratory system ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Swine ; Vertebrates: respiratory system</subject><ispartof>Journal of applied physiology (1985), 2002-03, Vol.92 (3), p.1119-1124</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Physiological Society Mar 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-24d778dce7cc6204e991bd73974d90369eac4823cb45036d73d483c1095967403</citedby><cites>FETCH-LOGICAL-c510t-24d778dce7cc6204e991bd73974d90369eac4823cb45036d73d483c1095967403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13509651$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11842048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Noble, P. B</creatorcontrib><creatorcontrib>Turner, D. J</creatorcontrib><creatorcontrib>Mitchell, H. W</creatorcontrib><title>Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Department of Physiology, University of Western
Australia, Nedlands, Western Australia 6009, Australia
Structural components of the
airway wall may act to load airway smooth muscle and restrict airway
narrowing. In this study, the effect of load on airway narrowing was
investigated in pig isolated bronchial segments. In some bronchi,
pieces of cartilage were removed by careful dissection. Airway
narrowing was produced by maximum electrical field stimulation. An
endoscope was used to record lumen narrowing. The compliance of the
bronchial segments was determined from the cross-sectional area of the
lumen and the transmural pressure. Airway narrowing and the velocity of airway narrowing were increased in cartilage-removed airways compared with intact control bronchi. Morphometric assessment of smooth muscle
length showed greater muscle shortening to acetylcholine in
cartilage-removed airways than in controls. Airway narrowing was
positively correlated with airway compliance. Compliance and area of
cartilage were negatively correlated. These results show that airway
narrowing is increased in compliant airways and that cartilage
significantly loads airway smooth muscle in whole bronchi.
airway smooth muscle; asthma</description><subject>Acetylcholine - pharmacology</subject><subject>Air breathing</subject><subject>Animals</subject><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Bronchi - drug effects</subject><subject>Bronchi - physiology</subject><subject>Bronchoconstriction - physiology</subject><subject>Bronchoscopy</subject><subject>Cartilage - physiology</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Lung Compliance</subject><subject>Muscle Contraction</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Pressure</subject><subject>Respiratory system</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Swine</subject><subject>Vertebrates: respiratory system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kFGL1DAUhYMo7rj6FzQIig_bMUnTpnlcFleFhQVZX3wJmSRtM6RJTVrG-femTnGXhc3LJdzvnHvvAeAdRluMK_J5L8fRjf0x2eC2CNU12RKE8DOwyV1S4Brh52DTsAoVrGrYGXiV0j4DlFb4JTjDuKEE0WYDfv0wTk42-NTbEYYWShsP8gi9jDEcrO8uoArD6Kz0ylxA6TVUMk7Wyc5A66FNIeuNhrsYvOqtdDCZbjB-Sq_Bi1a6ZN6s9Rz8vP5yd_WtuLn9-v3q8qZQFUZTQahmrNHKMKXqvJThHO80KzmjmqOy5kYq2pBS7WiVv7mjaVMqjHjFa0ZReQ4-nnzHGH7PJk1isEkZ56Q3YU6C5asZpSSD7x-B-zBHn3cTJL8cT724sROkYkgpmlaM0Q4yHgVGYslePMxe_MteLNqsfLvaz7vB6HvdGnYGPqyATEq6NuZMbbrnygrxulqMPp243nb9wUYj1mmhOy7TBSeizLaYZ5Q-jV7Pzt2ZP9Oi-S8Ro27LvxhmsS8</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Noble, P. B</creator><creator>Turner, D. J</creator><creator>Mitchell, H. W</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments</title><author>Noble, P. B ; Turner, D. J ; Mitchell, H. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-24d778dce7cc6204e991bd73974d90369eac4823cb45036d73d483c1095967403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Air breathing</topic><topic>Animals</topic><topic>Asthma</topic><topic>Biological and medical sciences</topic><topic>Bronchi - drug effects</topic><topic>Bronchi - physiology</topic><topic>Bronchoconstriction - physiology</topic><topic>Bronchoscopy</topic><topic>Cartilage - physiology</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>In Vitro Techniques</topic><topic>Lung Compliance</topic><topic>Muscle Contraction</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Pressure</topic><topic>Respiratory system</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Swine</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noble, P. B</creatorcontrib><creatorcontrib>Turner, D. J</creatorcontrib><creatorcontrib>Mitchell, H. 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B</au><au>Turner, D. J</au><au>Mitchell, H. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>92</volume><issue>3</issue><spage>1119</spage><epage>1124</epage><pages>1119-1124</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Department of Physiology, University of Western
Australia, Nedlands, Western Australia 6009, Australia
Structural components of the
airway wall may act to load airway smooth muscle and restrict airway
narrowing. In this study, the effect of load on airway narrowing was
investigated in pig isolated bronchial segments. In some bronchi,
pieces of cartilage were removed by careful dissection. Airway
narrowing was produced by maximum electrical field stimulation. An
endoscope was used to record lumen narrowing. The compliance of the
bronchial segments was determined from the cross-sectional area of the
lumen and the transmural pressure. Airway narrowing and the velocity of airway narrowing were increased in cartilage-removed airways compared with intact control bronchi. Morphometric assessment of smooth muscle
length showed greater muscle shortening to acetylcholine in
cartilage-removed airways than in controls. Airway narrowing was
positively correlated with airway compliance. Compliance and area of
cartilage were negatively correlated. These results show that airway
narrowing is increased in compliant airways and that cartilage
significantly loads airway smooth muscle in whole bronchi.
airway smooth muscle; asthma</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11842048</pmid><doi>10.1152/japplphysiol.00662.2001</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acetylcholine - pharmacology Air breathing Animals Asthma Biological and medical sciences Bronchi - drug effects Bronchi - physiology Bronchoconstriction - physiology Bronchoscopy Cartilage - physiology Electric Stimulation Female Fundamental and applied biological sciences. Psychology In Vitro Techniques Lung Compliance Muscle Contraction Muscle, Smooth - drug effects Muscle, Smooth - physiology Pressure Respiratory system Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Swine Vertebrates: respiratory system |
| title | Relationship of airway narrowing, compliance, and cartilage in isolated bronchial segments |
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