Effects of endurance exercise training on muscle glycogen accumulation in humans
Washington University School of Medicine, St. Louis, Missouri 63110 The purpose of this investigation was to determine whether endurance exercise training increases the ability of human skeletal muscle to accumulate glycogen after exercise. Subjects (4 women and 2 men, 31 ± 8 yr old) performed high-...
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| Veröffentlicht in: | Journal of applied physiology (1985) 1999-07, Vol.87 (1), p.222-226 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Greiwe, Jeffrey S Hickner, Robert C Hansen, Polly A Racette, Susan B Chen, May M Holloszy, John O |
| description | Washington University School of Medicine, St. Louis, Missouri 63110
The purpose of
this investigation was to determine whether endurance exercise training
increases the ability of human skeletal muscle to accumulate glycogen
after exercise. Subjects (4 women and 2 men, 31 ± 8 yr old)
performed high-intensity stationary cycling 3 days/wk and continuous
running 3 days/wk for 10 wk. Muscle glycogen concentration was measured
after a glycogen-depleting exercise bout before and after endurance
training. Muscle glycogen accumulation rate from 15 min to 6 h after
exercise was twofold higher ( P |
| doi_str_mv | 10.1152/jappl.1999.87.1.222 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_222187765</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>48845319</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-43eb7eb362cbb66a3348bc5a8a60e32ff2b1d52d8f93e3eb6ff902f721b22b493</originalsourceid><addsrcrecordid>eNp1kF2L1DAUhoso7uzqLxCkiKxXU_PRNsmlLLsqLOjFeh3S9KSTIU1r0rA7_97UGRkRvDoX53nPeXmK4g1GFcYN-bhX8-wqLISoOKtwRQh5Vmzyhmxxi_DzYsNZg7as4eyiuIxxjxCu6wa_LC4wqpFoGN8U32-NAb3EcjIl-D4F5TWU8ARB2wjlEpT11g_l5MsxRe2gHNxBTwP4UmmdxuTUYvPS-nKXRuXjq-KFUS7C69O8Kn7c3T7cfNnef_v89ebT_VbXQizbmkLHoKMt0V3XtorSmne6UVy1CCgxhnS4b0jPjaCQ2dYYgYhhBHeEdLWgV8X18e4cpp8J4iJHGzU4pzxMKcpWCEQFZRl89w-4n1LwuZvMxjBnrG0yRI-QDlOMAYycgx1VOEiM5Gpb_rYtV9uSM4nXbE69PZ1O3Qj9X5mj3gy8PwEqauXMatfGM8d5nRuev-_ssHu0AeS8O0Q7uWk4yLvk3AM8LWuDP5_l3Juc-vD_VIbPPX8BYOWqZQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222187765</pqid></control><display><type>article</type><title>Effects of endurance exercise training on muscle glycogen accumulation in humans</title><source>MEDLINE</source><source>American Physiological Society</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Greiwe, Jeffrey S ; Hickner, Robert C ; Hansen, Polly A ; Racette, Susan B ; Chen, May M ; Holloszy, John O</creator><creatorcontrib>Greiwe, Jeffrey S ; Hickner, Robert C ; Hansen, Polly A ; Racette, Susan B ; Chen, May M ; Holloszy, John O</creatorcontrib><description>Washington University School of Medicine, St. Louis, Missouri 63110
The purpose of
this investigation was to determine whether endurance exercise training
increases the ability of human skeletal muscle to accumulate glycogen
after exercise. Subjects (4 women and 2 men, 31 ± 8 yr old)
performed high-intensity stationary cycling 3 days/wk and continuous
running 3 days/wk for 10 wk. Muscle glycogen concentration was measured
after a glycogen-depleting exercise bout before and after endurance
training. Muscle glycogen accumulation rate from 15 min to 6 h after
exercise was twofold higher ( P < 0.05) in the trained than in the untrained state: 10.5 ± 0.2 and
4.5 ± 1.3 mmol · kg wet
wt 1 · h 1 ,
respectively. Muscle glycogen concentration was higher
( P < 0.05) in the trained than in
the untrained state at 15 min, 6 h, and 48 h after exercise. Muscle
GLUT-4 content after exercise was twofold higher
( P < 0.05) in the trained than in
the untrained state (10.7 ± 1.2 and 4.7 ± 0.7 optical density
units, respectively) and was correlated with muscle glycogen
concentration 6 h after exercise ( r = 0.64, P < 0.05). Total glycogen
synthase activity and the percentage of glycogen synthase I were not
significantly different before and after training at 15 min, 6 h, and
48 h after exercise. We conclude that endurance exercise training
enhances the capacity of human skeletal muscle to accumulate glycogen
after glycogen-depleting exercise.
GLUT-4 glucose transporter; glycogen supercompensation; glycogen
synthase activity</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1999.87.1.222</identifier><identifier>PMID: 10409578</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adult ; Anatomy & physiology ; Biological and medical sciences ; Carbohydrates ; Citrate (si)-Synthase - metabolism ; Dietary Carbohydrates - administration & dosage ; Exercise ; Exercise - physiology ; Exercise Test ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose Transporter Type 4 ; Glycogen - metabolism ; Glycogen Synthase - metabolism ; Hexokinase - metabolism ; Humans ; Male ; Metabolisms and neurohumoral controls ; Monosaccharide Transport Proteins - metabolism ; Muscle Proteins ; Muscle, Skeletal - metabolism ; Muscular system ; Physical Endurance - physiology ; Space life sciences ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of applied physiology (1985), 1999-07, Vol.87 (1), p.222-226</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright American Physiological Society Jul 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-43eb7eb362cbb66a3348bc5a8a60e32ff2b1d52d8f93e3eb6ff902f721b22b493</citedby><cites>FETCH-LOGICAL-c499t-43eb7eb362cbb66a3348bc5a8a60e32ff2b1d52d8f93e3eb6ff902f721b22b493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3026,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1884373$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10409578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Greiwe, Jeffrey S</creatorcontrib><creatorcontrib>Hickner, Robert C</creatorcontrib><creatorcontrib>Hansen, Polly A</creatorcontrib><creatorcontrib>Racette, Susan B</creatorcontrib><creatorcontrib>Chen, May M</creatorcontrib><creatorcontrib>Holloszy, John O</creatorcontrib><title>Effects of endurance exercise training on muscle glycogen accumulation in humans</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Washington University School of Medicine, St. Louis, Missouri 63110
The purpose of
this investigation was to determine whether endurance exercise training
increases the ability of human skeletal muscle to accumulate glycogen
after exercise. Subjects (4 women and 2 men, 31 ± 8 yr old)
performed high-intensity stationary cycling 3 days/wk and continuous
running 3 days/wk for 10 wk. Muscle glycogen concentration was measured
after a glycogen-depleting exercise bout before and after endurance
training. Muscle glycogen accumulation rate from 15 min to 6 h after
exercise was twofold higher ( P < 0.05) in the trained than in the untrained state: 10.5 ± 0.2 and
4.5 ± 1.3 mmol · kg wet
wt 1 · h 1 ,
respectively. Muscle glycogen concentration was higher
( P < 0.05) in the trained than in
the untrained state at 15 min, 6 h, and 48 h after exercise. Muscle
GLUT-4 content after exercise was twofold higher
( P < 0.05) in the trained than in
the untrained state (10.7 ± 1.2 and 4.7 ± 0.7 optical density
units, respectively) and was correlated with muscle glycogen
concentration 6 h after exercise ( r = 0.64, P < 0.05). Total glycogen
synthase activity and the percentage of glycogen synthase I were not
significantly different before and after training at 15 min, 6 h, and
48 h after exercise. We conclude that endurance exercise training
enhances the capacity of human skeletal muscle to accumulate glycogen
after glycogen-depleting exercise.
GLUT-4 glucose transporter; glycogen supercompensation; glycogen
synthase activity</description><subject>Adult</subject><subject>Anatomy & physiology</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates</subject><subject>Citrate (si)-Synthase - metabolism</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Transporter Type 4</subject><subject>Glycogen - metabolism</subject><subject>Glycogen Synthase - metabolism</subject><subject>Hexokinase - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Monosaccharide Transport Proteins - metabolism</subject><subject>Muscle Proteins</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscular system</subject><subject>Physical Endurance - physiology</subject><subject>Space life sciences</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF2L1DAUhoso7uzqLxCkiKxXU_PRNsmlLLsqLOjFeh3S9KSTIU1r0rA7_97UGRkRvDoX53nPeXmK4g1GFcYN-bhX8-wqLISoOKtwRQh5Vmzyhmxxi_DzYsNZg7as4eyiuIxxjxCu6wa_LC4wqpFoGN8U32-NAb3EcjIl-D4F5TWU8ARB2wjlEpT11g_l5MsxRe2gHNxBTwP4UmmdxuTUYvPS-nKXRuXjq-KFUS7C69O8Kn7c3T7cfNnef_v89ebT_VbXQizbmkLHoKMt0V3XtorSmne6UVy1CCgxhnS4b0jPjaCQ2dYYgYhhBHeEdLWgV8X18e4cpp8J4iJHGzU4pzxMKcpWCEQFZRl89w-4n1LwuZvMxjBnrG0yRI-QDlOMAYycgx1VOEiM5Gpb_rYtV9uSM4nXbE69PZ1O3Qj9X5mj3gy8PwEqauXMatfGM8d5nRuev-_ssHu0AeS8O0Q7uWk4yLvk3AM8LWuDP5_l3Juc-vD_VIbPPX8BYOWqZQ</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Greiwe, Jeffrey S</creator><creator>Hickner, Robert C</creator><creator>Hansen, Polly A</creator><creator>Racette, Susan B</creator><creator>Chen, May M</creator><creator>Holloszy, John O</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Effects of endurance exercise training on muscle glycogen accumulation in humans</title><author>Greiwe, Jeffrey S ; Hickner, Robert C ; Hansen, Polly A ; Racette, Susan B ; Chen, May M ; Holloszy, John O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-43eb7eb362cbb66a3348bc5a8a60e32ff2b1d52d8f93e3eb6ff902f721b22b493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Anatomy & physiology</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates</topic><topic>Citrate (si)-Synthase - metabolism</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Transporter Type 4</topic><topic>Glycogen - metabolism</topic><topic>Glycogen Synthase - metabolism</topic><topic>Hexokinase - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Monosaccharide Transport Proteins - metabolism</topic><topic>Muscle Proteins</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscular system</topic><topic>Physical Endurance - physiology</topic><topic>Space life sciences</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greiwe, Jeffrey S</creatorcontrib><creatorcontrib>Hickner, Robert C</creatorcontrib><creatorcontrib>Hansen, Polly A</creatorcontrib><creatorcontrib>Racette, Susan B</creatorcontrib><creatorcontrib>Chen, May M</creatorcontrib><creatorcontrib>Holloszy, John O</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greiwe, Jeffrey S</au><au>Hickner, Robert C</au><au>Hansen, Polly A</au><au>Racette, Susan B</au><au>Chen, May M</au><au>Holloszy, John O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of endurance exercise training on muscle glycogen accumulation in humans</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>87</volume><issue>1</issue><spage>222</spage><epage>226</epage><pages>222-226</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Washington University School of Medicine, St. Louis, Missouri 63110
The purpose of
this investigation was to determine whether endurance exercise training
increases the ability of human skeletal muscle to accumulate glycogen
after exercise. Subjects (4 women and 2 men, 31 ± 8 yr old)
performed high-intensity stationary cycling 3 days/wk and continuous
running 3 days/wk for 10 wk. Muscle glycogen concentration was measured
after a glycogen-depleting exercise bout before and after endurance
training. Muscle glycogen accumulation rate from 15 min to 6 h after
exercise was twofold higher ( P < 0.05) in the trained than in the untrained state: 10.5 ± 0.2 and
4.5 ± 1.3 mmol · kg wet
wt 1 · h 1 ,
respectively. Muscle glycogen concentration was higher
( P < 0.05) in the trained than in
the untrained state at 15 min, 6 h, and 48 h after exercise. Muscle
GLUT-4 content after exercise was twofold higher
( P < 0.05) in the trained than in
the untrained state (10.7 ± 1.2 and 4.7 ± 0.7 optical density
units, respectively) and was correlated with muscle glycogen
concentration 6 h after exercise ( r = 0.64, P < 0.05). Total glycogen
synthase activity and the percentage of glycogen synthase I were not
significantly different before and after training at 15 min, 6 h, and
48 h after exercise. We conclude that endurance exercise training
enhances the capacity of human skeletal muscle to accumulate glycogen
after glycogen-depleting exercise.
GLUT-4 glucose transporter; glycogen supercompensation; glycogen
synthase activity</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>10409578</pmid><doi>10.1152/jappl.1999.87.1.222</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of applied physiology (1985), 1999-07, Vol.87 (1), p.222-226 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_proquest_journals_222187765 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Anatomy & physiology Biological and medical sciences Carbohydrates Citrate (si)-Synthase - metabolism Dietary Carbohydrates - administration & dosage Exercise Exercise - physiology Exercise Test Female Fundamental and applied biological sciences. Psychology Glucose Transporter Type 4 Glycogen - metabolism Glycogen Synthase - metabolism Hexokinase - metabolism Humans Male Metabolisms and neurohumoral controls Monosaccharide Transport Proteins - metabolism Muscle Proteins Muscle, Skeletal - metabolism Muscular system Physical Endurance - physiology Space life sciences Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of endurance exercise training on muscle glycogen accumulation in humans |
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