Genetic distribution analyses and population background explorations of Gansu Yugur and Guizhou Miao groups via InDel markers
Insertion and deletion markers (InDels) have gained considerable attentions in population genetics and forensic research. In this study, we investigated genetic distributions of 30 InDels in Gansu Yugur and Guizhou Miao groups and evaluated their forensic application values. Genetic relationship ana...
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| Veröffentlicht in: | Journal of human genetics 2019-06, Vol.64 (6), p.535-543 |
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| creator | Yang, Chun-Hua Jin, Xiao-Ye Guo, Yu-Xin Cui, Wei Chen, Chong Meng, Hao-Tian Zhu, Bo-Feng |
| description | Insertion and deletion markers (InDels) have gained considerable attentions in population genetics and forensic research. In this study, we investigated genetic distributions of 30 InDels in Gansu Yugur and Guizhou Miao groups and evaluated their forensic application values. Genetic relationship analyses between Gansu Yugur, Guizhou Miao groups and other published populations were conducted based on these 30 InDels. Power of discrimination and power of exclusion in trio and duo cases of 30 InDels ranged from 0.3528 to 0.6247, 0.0937 to 0.1873, and 0.0219 to 0.1247 in Gansu Yugur group; and they ranged from 0.2579 to 0.6247, 0.0671 to 0.1874, and 0.0105 to 0.1247 in Guizhou Miao group. Obtained cumulative power of discrimination values indicated these InDels could be used for forensic individual identifications in both ethnic groups. Principal component analysis and phylogenetic reconstruction revealed that Gansu Yugur and Guizhou Miao groups had close affinities with their neighboring populations. Genetic structure analyses among these populations also indicated that studied Gansu Yugur and Guizhou Miao groups showed similar genetic structure with their neighboring populations. Further analyses of Y-STR, mtDNA, and ancestry informative markers should be conducted to better understand genetic backgrounds of Gansu Yugur and Guizhou Miao groups in the future. |
| doi_str_mv | 10.1038/s10038-019-0595-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2221826674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2221826674</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-bf59a6ec6886900c3ad849664cd21fb077575c4740412ae3bba20a63fa333d3</originalsourceid><addsrcrecordid>eNo9kM1OwzAQhC0EoqXwAFyQJc4G_8VJjqhAqFTEAQ5wspzEKWnTONgxoki8O25aOO1oNLPa_QA4J_iKYJZcO4LDQJikCEdphNgBGBPOIkQZfT0cNEcREWQETpxb4pCmMT0GI4ZTzjkmY_CT6Vb3dQHL2vW2zn1fmxaqVjUbp10QJexM5xs1-LkqVgtrfHD1V9cYO9gOmgpmqnUevvmFt0Mr8_X3u_HwsVYGbjudg5-1grP2VjdwrexKW3cKjirVOH22nxPwfH_3Mn1A86dsNr2Zo4JFrEd5FaVK6EIkiUgxLpgqE54KwYuSkirHcRzFUcFjjjmhSrM8VxQrwSrFGCvZBFzutnbWfHjterk03oYXnaSUkoQKEfOQIrtUYY1zVleys3W4cyMJllvccodbBtxyi1uy0LnYb_b5Wpf_jT--7BfH43zC</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2221826674</pqid></control><display><type>article</type><title>Genetic distribution analyses and population background explorations of Gansu Yugur and Guizhou Miao groups via InDel markers</title><source>MEDLINE</source><source>Springer journals</source><creator>Yang, Chun-Hua ; Jin, Xiao-Ye ; Guo, Yu-Xin ; Cui, Wei ; Chen, Chong ; Meng, Hao-Tian ; Zhu, Bo-Feng</creator><creatorcontrib>Yang, Chun-Hua ; Jin, Xiao-Ye ; Guo, Yu-Xin ; Cui, Wei ; Chen, Chong ; Meng, Hao-Tian ; Zhu, Bo-Feng</creatorcontrib><description>Insertion and deletion markers (InDels) have gained considerable attentions in population genetics and forensic research. In this study, we investigated genetic distributions of 30 InDels in Gansu Yugur and Guizhou Miao groups and evaluated their forensic application values. Genetic relationship analyses between Gansu Yugur, Guizhou Miao groups and other published populations were conducted based on these 30 InDels. Power of discrimination and power of exclusion in trio and duo cases of 30 InDels ranged from 0.3528 to 0.6247, 0.0937 to 0.1873, and 0.0219 to 0.1247 in Gansu Yugur group; and they ranged from 0.2579 to 0.6247, 0.0671 to 0.1874, and 0.0105 to 0.1247 in Guizhou Miao group. Obtained cumulative power of discrimination values indicated these InDels could be used for forensic individual identifications in both ethnic groups. Principal component analysis and phylogenetic reconstruction revealed that Gansu Yugur and Guizhou Miao groups had close affinities with their neighboring populations. Genetic structure analyses among these populations also indicated that studied Gansu Yugur and Guizhou Miao groups showed similar genetic structure with their neighboring populations. Further analyses of Y-STR, mtDNA, and ancestry informative markers should be conducted to better understand genetic backgrounds of Gansu Yugur and Guizhou Miao groups in the future.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1038/s10038-019-0595-3</identifier><identifier>PMID: 30944401</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Alleles ; Asian Continental Ancestry Group - genetics ; China ; Chromosomes, Human, Y - genetics ; Deoxyribonucleic acid ; DNA ; DNA, Mitochondrial - genetics ; Ethnic Groups - genetics ; Female ; Forensic science ; Forensic Sciences ; Genetic analysis ; Genetic relationship ; Genetic structure ; Genetic Testing ; Genetic Variation - genetics ; Genetics, Population ; Genotype ; Haplotypes - genetics ; Humans ; INDEL Mutation - genetics ; Insertion ; Language ; Male ; Minority & ethnic groups ; Mitochondrial DNA ; Mutation ; Phylogeny ; Population genetics ; Population studies ; Power ; Principal components analysis</subject><ispartof>Journal of human genetics, 2019-06, Vol.64 (6), p.535-543</ispartof><rights>The Author(s), under exclusive licence to The Japan Society of Human Genetics 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-bf59a6ec6886900c3ad849664cd21fb077575c4740412ae3bba20a63fa333d3</citedby><cites>FETCH-LOGICAL-c353t-bf59a6ec6886900c3ad849664cd21fb077575c4740412ae3bba20a63fa333d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30944401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Chun-Hua</creatorcontrib><creatorcontrib>Jin, Xiao-Ye</creatorcontrib><creatorcontrib>Guo, Yu-Xin</creatorcontrib><creatorcontrib>Cui, Wei</creatorcontrib><creatorcontrib>Chen, Chong</creatorcontrib><creatorcontrib>Meng, Hao-Tian</creatorcontrib><creatorcontrib>Zhu, Bo-Feng</creatorcontrib><title>Genetic distribution analyses and population background explorations of Gansu Yugur and Guizhou Miao groups via InDel markers</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><description>Insertion and deletion markers (InDels) have gained considerable attentions in population genetics and forensic research. In this study, we investigated genetic distributions of 30 InDels in Gansu Yugur and Guizhou Miao groups and evaluated their forensic application values. Genetic relationship analyses between Gansu Yugur, Guizhou Miao groups and other published populations were conducted based on these 30 InDels. Power of discrimination and power of exclusion in trio and duo cases of 30 InDels ranged from 0.3528 to 0.6247, 0.0937 to 0.1873, and 0.0219 to 0.1247 in Gansu Yugur group; and they ranged from 0.2579 to 0.6247, 0.0671 to 0.1874, and 0.0105 to 0.1247 in Guizhou Miao group. Obtained cumulative power of discrimination values indicated these InDels could be used for forensic individual identifications in both ethnic groups. Principal component analysis and phylogenetic reconstruction revealed that Gansu Yugur and Guizhou Miao groups had close affinities with their neighboring populations. Genetic structure analyses among these populations also indicated that studied Gansu Yugur and Guizhou Miao groups showed similar genetic structure with their neighboring populations. Further analyses of Y-STR, mtDNA, and ancestry informative markers should be conducted to better understand genetic backgrounds of Gansu Yugur and Guizhou Miao groups in the future.</description><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>China</subject><subject>Chromosomes, Human, Y - genetics</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Mitochondrial - genetics</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>Forensic science</subject><subject>Forensic Sciences</subject><subject>Genetic analysis</subject><subject>Genetic relationship</subject><subject>Genetic structure</subject><subject>Genetic Testing</subject><subject>Genetic Variation - genetics</subject><subject>Genetics, Population</subject><subject>Genotype</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>INDEL Mutation - genetics</subject><subject>Insertion</subject><subject>Language</subject><subject>Male</subject><subject>Minority & ethnic groups</subject><subject>Mitochondrial DNA</subject><subject>Mutation</subject><subject>Phylogeny</subject><subject>Population genetics</subject><subject>Population studies</subject><subject>Power</subject><subject>Principal components analysis</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNo9kM1OwzAQhC0EoqXwAFyQJc4G_8VJjqhAqFTEAQ5wspzEKWnTONgxoki8O25aOO1oNLPa_QA4J_iKYJZcO4LDQJikCEdphNgBGBPOIkQZfT0cNEcREWQETpxb4pCmMT0GI4ZTzjkmY_CT6Vb3dQHL2vW2zn1fmxaqVjUbp10QJexM5xs1-LkqVgtrfHD1V9cYO9gOmgpmqnUevvmFt0Mr8_X3u_HwsVYGbjudg5-1grP2VjdwrexKW3cKjirVOH22nxPwfH_3Mn1A86dsNr2Zo4JFrEd5FaVK6EIkiUgxLpgqE54KwYuSkirHcRzFUcFjjjmhSrM8VxQrwSrFGCvZBFzutnbWfHjterk03oYXnaSUkoQKEfOQIrtUYY1zVleys3W4cyMJllvccodbBtxyi1uy0LnYb_b5Wpf_jT--7BfH43zC</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Yang, Chun-Hua</creator><creator>Jin, Xiao-Ye</creator><creator>Guo, Yu-Xin</creator><creator>Cui, Wei</creator><creator>Chen, Chong</creator><creator>Meng, Hao-Tian</creator><creator>Zhu, Bo-Feng</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope></search><sort><creationdate>20190601</creationdate><title>Genetic distribution analyses and population background explorations of Gansu Yugur and Guizhou Miao groups via InDel markers</title><author>Yang, Chun-Hua ; Jin, Xiao-Ye ; Guo, Yu-Xin ; Cui, Wei ; Chen, Chong ; Meng, Hao-Tian ; Zhu, Bo-Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-bf59a6ec6886900c3ad849664cd21fb077575c4740412ae3bba20a63fa333d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alleles</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>China</topic><topic>Chromosomes, Human, Y - genetics</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Mitochondrial - genetics</topic><topic>Ethnic Groups - genetics</topic><topic>Female</topic><topic>Forensic science</topic><topic>Forensic Sciences</topic><topic>Genetic analysis</topic><topic>Genetic relationship</topic><topic>Genetic structure</topic><topic>Genetic Testing</topic><topic>Genetic Variation - genetics</topic><topic>Genetics, Population</topic><topic>Genotype</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>INDEL Mutation - genetics</topic><topic>Insertion</topic><topic>Language</topic><topic>Male</topic><topic>Minority & ethnic groups</topic><topic>Mitochondrial DNA</topic><topic>Mutation</topic><topic>Phylogeny</topic><topic>Population genetics</topic><topic>Population studies</topic><topic>Power</topic><topic>Principal components analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Chun-Hua</creatorcontrib><creatorcontrib>Jin, Xiao-Ye</creatorcontrib><creatorcontrib>Guo, Yu-Xin</creatorcontrib><creatorcontrib>Cui, Wei</creatorcontrib><creatorcontrib>Chen, Chong</creatorcontrib><creatorcontrib>Meng, Hao-Tian</creatorcontrib><creatorcontrib>Zhu, Bo-Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Chun-Hua</au><au>Jin, Xiao-Ye</au><au>Guo, Yu-Xin</au><au>Cui, Wei</au><au>Chen, Chong</au><au>Meng, Hao-Tian</au><au>Zhu, Bo-Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic distribution analyses and population background explorations of Gansu Yugur and Guizhou Miao groups via InDel markers</atitle><jtitle>Journal of human genetics</jtitle><addtitle>J Hum Genet</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>64</volume><issue>6</issue><spage>535</spage><epage>543</epage><pages>535-543</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>Insertion and deletion markers (InDels) have gained considerable attentions in population genetics and forensic research. In this study, we investigated genetic distributions of 30 InDels in Gansu Yugur and Guizhou Miao groups and evaluated their forensic application values. Genetic relationship analyses between Gansu Yugur, Guizhou Miao groups and other published populations were conducted based on these 30 InDels. Power of discrimination and power of exclusion in trio and duo cases of 30 InDels ranged from 0.3528 to 0.6247, 0.0937 to 0.1873, and 0.0219 to 0.1247 in Gansu Yugur group; and they ranged from 0.2579 to 0.6247, 0.0671 to 0.1874, and 0.0105 to 0.1247 in Guizhou Miao group. Obtained cumulative power of discrimination values indicated these InDels could be used for forensic individual identifications in both ethnic groups. Principal component analysis and phylogenetic reconstruction revealed that Gansu Yugur and Guizhou Miao groups had close affinities with their neighboring populations. Genetic structure analyses among these populations also indicated that studied Gansu Yugur and Guizhou Miao groups showed similar genetic structure with their neighboring populations. Further analyses of Y-STR, mtDNA, and ancestry informative markers should be conducted to better understand genetic backgrounds of Gansu Yugur and Guizhou Miao groups in the future.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>30944401</pmid><doi>10.1038/s10038-019-0595-3</doi><tpages>9</tpages></addata></record> |
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| subjects | Alleles Asian Continental Ancestry Group - genetics China Chromosomes, Human, Y - genetics Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Ethnic Groups - genetics Female Forensic science Forensic Sciences Genetic analysis Genetic relationship Genetic structure Genetic Testing Genetic Variation - genetics Genetics, Population Genotype Haplotypes - genetics Humans INDEL Mutation - genetics Insertion Language Male Minority & ethnic groups Mitochondrial DNA Mutation Phylogeny Population genetics Population studies Power Principal components analysis |
| title | Genetic distribution analyses and population background explorations of Gansu Yugur and Guizhou Miao groups via InDel markers |
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